Bioanalytical chemistry with scanning electrochemical microscopy

Abstract

Scanning electrochemical microscopy (SECM) is a powerful and suitable tool for visualizing local electrochemical activity as well as topography of surfaces. Due to the development of electrode manufacturing technology, high spatial resolution can be achieved, and various applications are possible by combining SECM with other technologies. Many studies have applied SECM to bioanalytical chemistry at the single‐cell level. The purpose of this review is to introduce various advanced nanoelectrode fabrication techniques and their subsequent applications in bioanalytical research using SECM.

Recent Advances in the Glass Pipet: from Fundament to Applications

“…For other SPM application, such as SECM and SECCM, a nanopipette is utilized for studying electrochemical properties of various surfaces. , In the case of SECM, localized chemical compounds in an electrolyte solution can be detected and even mapped on the sample surface by moving the probe toward or over the sample surface controlled by a precise motor positioning system. Various applications of SECM, including electrocatalysis, corrosion science, secondary batteries, and bioanalytical chemistry, , have been reported. Differing from the nanopipette in SICM application, the SECM probe is usually decorated by an ultramicroelectrode (UME) with an electroactive diameter of 10–25 μm or a nanoelectrode with an electroactive diameter of less than 1 μm.…”