Bioanalytical Approaches in Assessing Transformation Products

Denslow, Nancy D.; Maruya, Keith A.; Leusch, Frédéric D.L.

doi:10.1021/bk-2016-1242.ch004

Cited by 2 publications

(3 citation statements)

References 68 publications

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“…Consequently, the complementarity of biological assays with respect to chemical analyses fails in a sense, within the quality assessment of a natural waterbody (Escher et al, 2011) (Escher et al, 2015a) (Frederic D.L. Leusch et al, 2014) (Escher et al, 2013) (Tang et al, 2014) (Denslow et al, 2016) (Neale et al, 2017d). Given the context, the proposal of the derivation of effect-based trigger values bioanalytical equivalent concentrations (EBT-BEQ) appears to be quite promising (Tang et al, 2013) (Escher et al, 2018a) (Escher et al, 2015a) .…”

Section: Exploiting the Biological Responsesmentioning

confidence: 99%

Opinion paper about organic trace pollutants in wastewater: Toxicity assessment in a European perspective

Pedrazzani

Bertanza

Brnardić

et al. 2019

Science of The Total Environment

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This opinion paper focuses on the role of eco-toxicological tools in the assessment of possible impacts of emerging contaminants on the aquatic ecosystem, hence, on human health. Indeed, organic trace pollutants present in raw and treated wastewater are the pivot targets: a multidisciplinary approach allows defining the basic principles for managing this issue, from setting a proper monitoring campaign up to evaluating the optimal process treatment. Giving hints on trace pollutants fate and behaviour, attention is focused on the choice of the bioassay(s), by analysing the meaning of possible biological answers. Data interpretation and exploitation are detailed with the final goal of providing criteria in order to be able to select the best targeted treatment options.The manuscript deals with conventional and innovative analytical approaches for assessing toxicity, by reviewing laboratory and field assays; illustrative real scale and laboratory applications integrate and exemplify the proposed approach.

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Section: Exploiting the Biological Responsesmentioning

confidence: 99%

Opinion paper about organic trace pollutants in wastewater: Toxicity assessment in a European perspective

Pedrazzani

Bertanza

Brnardić

et al. 2019

Science of The Total Environment

View full text Add to dashboard Cite

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“…The complexity of the ambient matrices, low concentrations of TPs in real samples and the limited availability of reference materials all present challenges in identifying causative pollutants from environmental mixtures. 67 Therefore, the development of a tentative method to prioritize TPs is essential. To resolve the research needs, this research provides an integrated framework combining target and nontarget analysis, in vitro assay, and in silico simulation for evaluating the environmental risks of TPs of emerging contaminants.…”

Section: Environmental Implicationsmentioning

confidence: 99%

“…Due to the sophistication of natural aquatic environments, our understanding of the TPs of immense organic contaminants remains limited. The complexity of the ambient matrices, low concentrations of TPs in real samples and the limited availability of reference materials all present challenges in identifying causative pollutants from environmental mixtures . Therefore, the development of a tentative method to prioritize TPs is essential.…”

Section: Environmental Implicationsmentioning

confidence: 99%

Identification of Transformation Products of Organic UV Filters by Photooxidation and Their Differential Estrogenicity Assessment

Lu,

Chow,

Sun

et al. 2023

Environ. Sci. Technol.

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Organic ultraviolet filters (OUVFs) are extensively released into aquatic environments, where they undergo complex phototransformation. However, there is little knowledge regarding their transformation products (TPs) and associated endocrine disruption potentials. In the present study, we characterized the chemical and toxicological profiles of TPs for two common OUVFs, oxybenzone (BP3) and ethylhexyl methoxycinnamate (EHMC), by photooxidation under environmentally relevant conditions. It is hypothesized that TPs of the tested OUVFs will show varied estrogenicity at different reaction times. High-resolution liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) identified 17 TPs of 7 m/z for BP-3 and 13 TPs of 8 m/z for EHMC at confidence levels ≤2. Five novel TPs of 2 m/z were reported for the first time with structure-diagnostic MS/MS spectra. Estrogenicity assessment using the MCF-7-luc cell line showed discrepant estrogenic activities exhibited by OUVF-TPs over time. Specifically, BP3-TPs exhibited significantly greater estrogenicity than the parent at several reaction times, whereas EHMC-TPs displayed fluctuating estrogenicity with a declining trend. Correlation analysis coupled with molecular docking simulations further suggested several TPs of BP3 as potential endocrine disruptive compounds. These findings underscore the necessity of considering mixtures during chemical testing and risk assessment and highlight the potentially greater risks associated with post-transformation cocktails.

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Bioanalytical Approaches in Assessing Transformation Products

Cited by 2 publications

References 68 publications

Opinion paper about organic trace pollutants in wastewater: Toxicity assessment in a European perspective

Opinion paper about organic trace pollutants in wastewater: Toxicity assessment in a European perspective

Identification of Transformation Products of Organic UV Filters by Photooxidation and Their Differential Estrogenicity Assessment

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