Abstract:Functional oligopeptides derived from natural proteins
are often
used as targeting groups or therapeutic drugs but always suffer from
a dramatic bioaffinity decrease due to the loss of conformational
restriction in proteins, which increases their entropy state. It is
worth noting that the linear Cys-Arg-Gly-Asp-Ser (CRGDS) oligopeptide
can spontaneously restore its natural conformation by anchoring one
terminus and forming hydrogen bonds on another terminus, on protein-like
zwitterionic fifth-generation polyam… Show more
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