Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole for treatment of vaginal Candidiasis

Gupta, N. Vishal; Natasha, Shirodker; Getyala, Anil; Bhat, R

doi:10.2478/acph-2013-0027

Cited by 26 publications

(19 citation statements)

References 13 publications

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“…It is insoluble in aqueous medium and has low permeability and pH-independent swelling [33]. Its inclusion in pharmaceutical forms of vaginal administration to date is much scarcer than for the polymers described above, and it is mainly used in nanocapsules, microspheres, and microparticles [21,34,35]. …”

Section: Introductionmentioning

confidence: 99%

Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV

et al. 2017

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The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Vaginal mucoadhesive tablets can be developed by including natural polymers that have good binding capacity with mucosal tissues, such as chitosan or guar gum, semisynthetic polymers such as hydroxypropylmethyl cellulose, or synthetic polymers such as Eudragit® RS. This paper assesses the potential of chitosan for the development of sustained-release vaginal tablets of Tenofovir and compares it with different polymers. The parameters assessed were the permanence time of the bioadhesion—determined ex vivo using bovine vaginal mucosa as substrate—the drug release profiles from the formulation to the medium (simulated vaginal fluid), and swelling profiles in the same medium. Chitosan can be said to allow the manufacture of tablets that remain adhered to the vaginal mucosa and release the drug in a sustained way, with low toxicity and moderate swelling that ensures the comfort of the patient and may be useful for the prevention of sexual transmission of HIV.

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Section: Introductionmentioning

confidence: 99%

Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV

et al. 2017

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“…imizadole and nystatin) microspheres [163][164][165] and nanospheres [166]. This strategy aims at improving drug retention in the vagina, due to their mucoadhesive properties while allowing for controlled drug release with no loss or eventually enhancement of anti-Candida activity [164].…”

Section: Several Authors Used Mucoadhesive Polymers Such As Eudragit®mentioning

confidence: 99%

New strategies for local treatment of vaginal infections

Palmeira‐de‐Oliveira

Martinez-de-Oliveira

2015

Advanced Drug Delivery Reviews

143

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“…The application of chitin and chitosan in nanomedicine had been widely reported for the targeted delivery of drugs in nanoparticle formulations and also for gene therapy [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The Chemistry of Chitin and Chitosan Justifying their Nanomedical Utilities

Louis¹,

Pi²,

Oc³

et al. 2018

Biochem Pharmacol

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Chitin and chitosan are among the most commonly used natural polymers in nanomedicine because they display very attractive characteristics for drug delivery and have proven very effective when formulated in nanoparticle forms. Properties such as the cationic character and the solubility of chitosan in aqueous medium have been reported as determinants of the success of this polysaccharide. However, its most attractive property relies on its ability to adhere to mucosal surfaces, leading to prolonged residence time at drug absorption sites and enabling higher drug permeation. This is because chitin and chitosan are able to interact with anionic agents and form water-soluble barriers which participate in drug release. The wide nanomedical applications of chitin and chitosan are due not only to their excellent biocompatibility, biodegradability, non-toxicity, ordourless nature and economic efficiency but also due to their distinct chemical structure with high percentage of primary amino groups and acetamido groups in chitosan and chitin respectively, for easy binding to bio-molecules such as DNAs and proteins. This review highlights the properties and modifications of chitin and chitosan which are responsible for the wide range of applications of these materials, particularly in nanomedicine for drug delivery and gene therapy, thereby encouraging more research into the exploration of their properties and modifications for improved applications.

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Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole for treatment of vaginal Candidiasis

Cited by 26 publications

References 13 publications

Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV

Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive Vaginal Systems for Prevention of Sexual Transmission of HIV

New strategies for local treatment of vaginal infections

The Chemistry of Chitin and Chitosan Justifying their Nanomedical Utilities

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