Bioadhesive dermal patch as promising approach for improved antibacterial activity of bioactive compound of Zingiber cassumunar Roxb in ex vivo Staphylococcus aureus skin infection model

Rahman, Latifah; Lembang, Reni Sriyani; Lallo, Subehan; Handayani, Sri Resky; Usmanengsi,; Permana, Andi Dian

doi:10.1016/j.jddst.2021.102522

Cited by 12 publications

(7 citation statements)

References 31 publications

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“…The MNs were successfully folded and unfolded more than 300 times without encountering any damage or cracks, suggesting that all developed MNs were flexible and exhibited adequate mechanical properties. 23,36 A highly acidic or alkaline pH can cause skin irritation, therefore the surface pH of the prepared MNs was determined. The surface pH of all the samples evaluated was in the range of 6.03 ± 0.01 to 6.24 ± 0.09 (Table 3), indicating that no skin irritation due to pH is expected upon their application.…”

Section: Resultsmentioning

confidence: 99%

Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery

et al. 2022

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“…For example, curcumin release from sodium CMC-based bioadhesive was significantly faster as compared to chitosanbased bioadhesive (Figure 4C). [105] The use of nanocarriers also influences drug release kinetics, [212] as it was demonstrated with decreased drug release following the encapsulation of tigecycline in gelatin NPs that were embedded in chitin-fibrin hydrogel. [119] Similar observations were also made with metronidazole-loaded chitosan (Figure 4D), [49] and l-glutamic-loaded PDA-modified ZnO NPs.…”

Section: Drug Release Kineticsmentioning

confidence: 99%

Bioadhesives with Antimicrobial Properties

et al. 2023

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Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds as compared to the traditional methods such as suturing and stapling on a variety of medical conditions. Composed of natural or synthetic polymers, these bioadhesives seal wounds and facilitate healing while preventing infections through the activity of locally released antimicrobial drugs, nanocomponents or inherently antimicrobial polymers. Although many different materials and strategies are employed to develop antimicrobial bioadhesives, the design of these biomaterials necessitates a prudent approach as achieving all the required properties including optimal adhesive and cohesive properties, biocompatibility, and antimicrobial activity can be challenging. Designing antimicrobial bioadhesives with tunable physical, chemical and biological properties will shed light on the path for future advancement of bioadhesives with antimicrobial properties. In this review, we discuss the requirements and commonly used strategies for developing bioadhesives with antimicrobial properties. In particular, we will summarize different methods for their synthesis and will review their experimental and clinical applications on a variety of organs. Advances in the design of bioadhesives with antimicrobial properties will pave the way for a better management of wounds to increase positive medical outcomes.This article is protected by copyright. All rights reserved

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“…Bioadhesive dermal patches of ginger were developed by Rahman et al and utilized as an antibacterial agent. 22 They found that >80% of bacterial infections were inhibited after the application of ginger bioadhesive patches in an ex vivo Staphylococcus aureus infection model in rat skin. Priprem et al 4 encapsulated GE into niosome vesicles, then incorporated these into a gel for topical delivery.…”

Section: Introductionmentioning

confidence: 99%

Ginger Extract–Loaded Transethosomes for Effective Transdermal Permeation and Anti-Inflammation in Rat Model

Hassan¹,

Hofni²,

Abourehab³

et al. 2023

IJN

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Introduction Ginger extract (GE) has sparked great interest due to its numerous biological benefits. However, it suffers from limited skin permeability, which challenges its transdermal application. The target of the current work was to develop transethosomes as a potential nanovehicle to achieve enhanced transdermal delivery of GE through the skin. Methods GE–loaded transethosomes were prepared by cold injection using different edge activators. The fabricated nanovesicles were evaluated for particle size, ζ-potential, encapsulation efficiency, and in vitro drug release. The selected formulation was then laden into the hydrogel system and evaluated for ex vivo permeability and in vivo anti-inflammatory activity in a carrageenan-induced rat-paw edema model. Results The selected formulation comprised of sodium deoxycholate exhibited particle size of 188.3±7.66 nm, ζ-potential of −38.6±0.08 mV, and encapsulation efficiency of 91.0%±0.24%. The developed transethosomal hydrogel containing hydroxypropyl methylcellulose was homogeneous, pseudoplastic, and demonstrated sustained drug release. Furthermore, it exhibited improved flux (12.61±0.45 μg.cm 2 /second), apparent skin permeability (2.43±0.008×10 −6 cm/second), and skin deposition compared to free GE hydrogel. In vivo testing and histopathological examination revealed that the GE transethosomal hydrogel exhibited significant inhibition of edema swelling compared to free GE hydrogel and ketoprofen gel. The animals that were treated with ginger transethosome hydrogel showed a significant decrement in reactive oxygen species and prostaglandin E 2 compared to untreated animals. Conclusion Transethosomes might be a promising new vehicle for GE for effective skin permeation and anti-inflammation. To the best of our knowledge, this work is the first utilization of transethosomes laden into hydrogel as a novel transdermal delivery system of GE.

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Bioadhesive dermal patch as promising approach for improved antibacterial activity of bioactive compound of Zingiber cassumunar Roxb in ex vivo Staphylococcus aureus skin infection model

Cited by 12 publications

References 31 publications

Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery

Preparation and characterization of flexible furosemide-loaded biodegradable microneedles for intradermal drug delivery

Bioadhesives with Antimicrobial Properties

Ginger Extract–Loaded Transethosomes for Effective Transdermal Permeation and Anti-Inflammation in Rat Model

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