Bioadhesive, Bioerodible Polymers for Increased Intestinal Uptake

Carino, Gerardo; Jacob, Jules S.; Chen, C. J.; Santos, Camilla A.; Hertzog, Benjamin; Mathiowitz, Edith

doi:10.1201/b14099-18

Cited by 10 publications

(13 citation statements)

References 16 publications

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“…Moreover, acid‐quantification may lead to better understanding of polymer degradation kinetics and mechanisms 18. Finally, the diffusion of these water‐soluble species out of polymer, depending on their type and rate, can likely affect the function of living tissues 24,25…”

Section: Introductionmentioning

confidence: 99%

Determination of water‐soluble acid distribution in poly(lactide‐co‐glycolide)

Ding

Schwendeman

2004

Journal of Pharmaceutical Sciences

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Determination of the kinetics of water-soluble degradation products inside poly(lactide-co-glycolide) (PLGA) delivery systems during polymer degradation is important to evaluate the polymer microclimate conditions, particularly microclimate pH changes for optimization of encapsulated drug stability. A pre-derivatization high-performance liquid chromatography (HPLC) method was developed for separation and quantification of water-soluble acid impurities and degradation products in PLGA. Thin PLGA films (approximately 200 microm) were incubated in PBS/0.02% Tween 80, pH 7.4, for 6 weeks. Water-soluble monomers and oligomers were obtained from polymer films after repeated CHCl(3)/H(2)O extraction and then derivatized into bromophenacyl esters. With the common chromophore, the esters were separated and quantified by HPLC with increased ultraviolet (UV) sensitivity at 254 nm. The total amount of water-soluble acids in the extract was validated by potentiometric titration with tetrabutyl ammonium hydroxide. During the first 3 weeks of incubation of PLGA 50:50 (inherent viscosity = 0.63 dL/g), the principal water-soluble acids in the polymer were glycolic, lactic, and lactoyllactic acids, and an unknown oligomer. After 4 weeks of incubation, a large fraction of higher molecular weight oligomers was observed. Pre-derivatization HPLC can be used to accurately measure water-soluble acid distribution, and may be invaluable to examine the degradation behavior of PLGAs, including the underlying mechanism of polymer microclimate pH development.

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Section: Introductionmentioning

confidence: 99%

Determination of water‐soluble acid distribution in poly(lactide‐co‐glycolide)

Ding

Schwendeman

2004

Journal of Pharmaceutical Sciences

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“…This was done by measuring the force of detachment as well as work of detachment using a CAHN machine. In addition we have demonstrated longer residence time for formulation made of p(FA:SA),14–24 and because of this some of these formulations will be referred to as encapsulated adhesive polymer and the PLA will be referred to as nonadhesive.…”

Section: Resultsmentioning

confidence: 91%

“…Our group has characterized the benefits of bioadhesive polymers and excipients extensively in a variety of applications, and improvements have been shown in the areas of mucosal translocation in the GI tract in a number of species, protein delivery, gene transfection, and modulation of release 5,14–24. We have also characterized in detail the bioadhesive properties of a variety of polymers using a CAHN machine to determine tensile force and the work of detachment, and have determined that p(FA:SA) is a very adhesive polymer 14.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Oral Bioavailability of the Poorly Soluble Drug Dicumarol with a Bioadhesive Polymer

Thanos

Goddard

et al. 2003

Journal of Pharmaceutical Sciences

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“…After pouring the polymer solution into silicone oil, petroleum ether was added and stirred until solvent was extracted into the oil solution. The resulting microspheres were then dried under vacuum 43 .…”

Section: Solvent Removal Methodsmentioning

confidence: 99%