Bioadhesion of polymers for BioMEMS

Tokachichu, Dharma R.; Bhushan, Bharat

doi:10.1109/tnano.2006.874047

Cited by 26 publications

(7 citation statements)

References 12 publications

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“…Our findings are similar to those published in Tokachichu et al, who observed a decrease in AFM adhesion values when modifying Polydimethylsiloxane (PDMS) discs with oxygen plasma alone and a further decrease in adhesion value when modifying them with a self‐assembling monolayer of Perfluorodecyltriethoxysilane. [ 30 ] Movahed et al also reported a decrease in adhesion values when modifying silicon‐incorporated diamond‐like coatings with both oxygen and argon plasma, simultaneously reporting an increase in hydrophilicity with the plasma treatments. [ 31 ] This supports our study in which increasing the hydrophilic properties of the PCL fibers using oxygen plasma and CL11 reduces the adhesive forces measured between the polymer and the AFM cantilever tip, which is hydrophobic in nature.…”

Section: Discussionmentioning

confidence: 99%

Aminosilane Functionalized Aligned Fiber PCL Scaffolds for Peripheral Nerve Repair

Taylor

Barnes

Koduri

et al. 2023

Macromolecular Bioscience

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Silane modification is a simple and cost‐effective tool to modify existing biomaterials for tissue engineering applications. Aminosilane layer deposition has previously been shown to control NG108‐15 neuronal cell and primary Schwann cell adhesion and differentiation by controlling deposition of ─NH2 groups at the submicron scale across the entirety of a surface by varying silane chain length. This is the first study toreport depositing 11‐aminoundecyltriethoxysilane (CL11) onto aligned Polycaprolactone (PCL) scaffolds for peripheral nerve regeneration. Fibers are manufactured via electrospinning and characterized using water contact angle measurements, atomic force microscopy (AFM), and X‐ray photoelectron spectroscopy (XPS). Confirmed modified fibers are investigated using in vitro cell culture of NG108‐15 neuronal cells and primary Schwann cells to determine cell viability, cell differentiation, and phenotype. CL11‐modified fibers significantly support NG108‐15 neuronal cell and Schwann cell viability. NG108‐15 neuronal cell differentiation maintains Schwann cell phenotype compared to unmodified PCL fiber scaffolds. 3D ex vivo culture of Dorsal root ganglion explants (DRGs) confirms further Schwann cell migration and longer neurite outgrowth from DRG explants cultured on CL11 fiber scaffolds compared to unmodified scaffolds. Thus, a reproducible and cost‐effective tool is reported to modify biomaterials with functional amine groups that can significantly improve nerve guidance devices and enhance nerve regeneration.

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Section: Discussionmentioning

confidence: 99%

Aminosilane Functionalized Aligned Fiber PCL Scaffolds for Peripheral Nerve Repair

Taylor

Barnes

Koduri

et al. 2023

Macromolecular Bioscience

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“…Commercial silicones suffer from poor adhesiveness that impacts devices both during processing and deployment. [272] Jeong et al designed and synthesized soft, stretchable, and adhesive PDMS by adding small volumes (20-40 µL in 10 g of PDMS) of ethoxylated polyethyleneimine (PEIE) with PDMS precursors prior to curing (Figure 7B). PEIE additives induce hetero geneity and increase sol content, thereby reducing the modulus to E PDMS+PEIE = 24 kPa from E PDMS = 1 MPa and increasing the force of interfacial adhe sion forces to F ad,PDMS+PEIE = 1.2 N compared to F ad,PDMS < 0.1 N (Sylgard 184).…”

Section: Figurementioning

confidence: 99%

“…Commercial silicones suffer from poor adhesiveness that impacts devices both during processing and deployment. [ 272 ] Jeong et al. designed and synthesized soft, stretchable, and adhesive PDMS by adding small volumes (20–40 µL in 10 g of PDMS) of ethoxylated polyethyleneimine (PEIE) with PDMS precursors prior to curing (Figure 7B).…”

Section: Substrates and Structural Materials For Flexible Bioelectronicsmentioning

confidence: 99%

Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine

et al. 2022

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Designing bioelectronic devices that seamlessly integrate with the human body is a technological pursuit of great importance. Bioelectronic medical devices that reliably and chronically interface with the body can advance neuroscience, health monitoring, diagnostics, and therapeutics. Recent major efforts focus on investigating strategies to fabricate flexible, stretchable, and soft electronic devices, and advances in materials chemistry have emerged as fundamental to the creation of the next generation of bioelectronics. This review summarizes contemporary advances and forthcoming technical challenges related to three principal components of bioelectronic devices: i) substrates and structural materials, ii) barrier and encapsulation materials, and iii) conductive materials. Through notable illustrations from the literature, integration and device fabrication strategies and associated challenges for each material class are highlighted.

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“…In the analysis of DNA purification, the surface area of channel was limited. Sample clogging occurs in the channel during testing [109][110][111].…”

Section: Biomemsmentioning

confidence: 99%

A Review on Key Issues and Challenges in Devices Level MEMS Testing

et al. 2016

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The present review provides information relevant to issues and challenges in MEMS testing techniques that are implemented to analyze the microelectromechanical systems (MEMS) behavior for specific application and operating conditions. MEMS devices are more complex and extremely diverse due to the immersion of multidomains. Their failure modes are distinctive under different circumstances. Therefore, testing of these systems at device level as well as at mass production level, that is, parallel testing, is becoming very challenging as compared to the IC test, because MEMS respond to electrical, physical, chemical, and optical stimuli. Currently, test systems developed for MEMS devices have to be customized due to their nondeterministic behavior and complexity. The accurate measurement of test systems for MEMS is difficult to quantify in the production phase. The complexity of the device to be tested required maturity in the test technique which increases the cost of test development; this practice is directly imposed on the device cost. This factor causes a delay in time-to-market.

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Bioadhesion of polymers for BioMEMS

Cited by 26 publications

References 12 publications

Aminosilane Functionalized Aligned Fiber PCL Scaffolds for Peripheral Nerve Repair

Aminosilane Functionalized Aligned Fiber PCL Scaffolds for Peripheral Nerve Repair

Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine

A Review on Key Issues and Challenges in Devices Level MEMS Testing

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