Bioactivity studies ofSalvia transsylvanica (Schur ex Griseb) grown in Egypt

Maklad, Yousreya A.; Aboutabl, E. A.; El‐Sherei, Moshera M.; Ibrahim, Khaled Meselhy

doi:10.1002/(sici)1099-1573(199903)13:2<147::aid-ptr397>3.0.co;2-e

Cited by 16 publications

(10 citation statements)

References 7 publications

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“…Recent studies showed that SE has anti-inflammatory, antispasmodic, and antidisquiet effects predicted in traditional medicine [34,67]. Our results are also consistent with other findings.…”

Section: Discussionsupporting

confidence: 93%

“…The results of this study showed that analgesic properties of SEs are dose-dependent, and both extracts were able to create analgesic effects. A study of the effects of Salvia transsylvanica bioactivity showed that preparations obtained from this plant possess significant analgesic, antipyretic, antiepileptic, antiinflammatory, antiulcerogenic, and tranquilizing activities, besides decreasing the bleeding time and exhibiting no central skeletal muscle relaxant effect, compared with control groups and standard drugs [34]. The anti-inflammatory effect of this plant is also remarkable; the anti-neuropathic action of this plant is probably due to the above effects.…”

Section: Discussionmentioning

confidence: 96%

“…After 48 h, the mixture was leached, and the solvent was extracted in a rotary evaporator adjusted at 70°C to medium speed. The caliginous fluid was spread on a window, and, after drying in a 50°C oven, the powder was gathered and used in our experiments [34].…”

Section: Animalsmentioning

confidence: 99%

“…A flavonoid, apigenin, e.g., was shown to protect neurons against amyloid protein (Aβ)-induced toxicity [33]. In addition to the antioxidant activity, many Salvia species and their isolated constituents demonstrate anti-inflammatory properties [32,34].…”

Section: Introductionmentioning

confidence: 99%

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Antinociceptive Effect of Salvia Extract on Cisplatin-Induced Hyperalgesia in Mice

Namvaran-Abbas-Abad

Tavakkoli

2012

Neurophysiology

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Experiments carried out on mice demonstrated that administration of a platinum-based drug, cisplatin, extensively used in anticancer chemotherapy, exerts significant hyperalgesic effects; it intensifies both phases of pain behavioral reactions induced in the formalin test. When introduction of cisplatin was combined with i.p. injections of 100 mg/kg of an aqueous-alcoholic extract from the leaves of Salvia officinalis, the second phase of cisplatin-enhanced pain in the formalin test was effectively suppressed; the effect was comparable with that provided by injections of morphine or even more intense.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Section: Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antinociceptive Effect of Salvia Extract on Cisplatin-Induced Hyperalgesia in Mice

Namvaran-Abbas-Abad

Tavakkoli

2012

Neurophysiology

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“…Most Salvia species are rich in essential oils, and various biologically active monoterpenoid/sesquiterpenoid have been reported in them possessing diverse biological activities such as antioxidant [8,9], anti-inflammatory [9,10], analgesic [11], anticonvulsant, anti-ulcerogenic, tranquillizing activities [12] and antibacterial activities [13]. Furthermore, the Salvia species, often pleasantly aromatic plants of potential economic interest, comprise the majority of the essential oil rich genera of the Lamiaceae, and particularly tend to accumulate monoterpenoid-rich essential oils.…”

Section: Introductionmentioning

confidence: 99%

ESSENTIAL AND FIXED OIL CHEMICAL COMPOSITIONS OF THE SEEDS FROM THE ENDEMIC SPECIES Salvia Sharifii RECH. F. & ESFAND

Alipour-Gougeh

Asgarpanah

2015

J. Chil. Chem. Soc.

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The essential oil content in the seeds of Salvia sharifii growing wild in south of Iran was found to be 0.2% (v/w). The essential oil was analyzed by GC and GC-MS. Twenty eight constituents, representing 85.0 % of the seeds essential oil were identified. The major components of the S. sharifii seeds essential oil were identified as sclareol (21.9%) and n-decane (17.3%). The fixed oil content and fatty acid composition of the seeds were also analyzed in order to determine their potential for human or animal consumption. The oil content in these edible seeds was found to be 19.9 %. The oil was analyzed by GC and GC/MS and five fatty acids identified which constituted 88.0 % of the oil. The main fatty acids of the oil were characterized as linoleic acid (39.7%) and linolenic acid (36.7%).

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Antinociceptive, antiinﬂammatory and acute toxicity effects of Salvia leriifolia Benth. seed extract in mice and rats

Hosseinzadeh

Haddadkhodaparast

Arash

2003

Phytotherapy Research

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The antinociceptive and antiinflammatory effects as well as the acute toxicity of Salvia leriifolia aqueous seed extract were studied in mice and rats. Antinociceptive activity was assessed using the hot-plate and tail flick tests. The effect on acute inflammation was studied using vascular permeability increased by acetic acid and xylene-induced ear oedema in mice. The activity against chronic inflammation was assessed using the cotton pellet test in rats. The LD(50) of the extract was found to be 19.5 g/kg (i.p.) in mice. The aqueous seed extract showed significant and dose-dependent (1.25-10 g/kg) antinociceptive activity over 7 h, and was inhibited by naloxone pretreatment. Significant and dose-dependent (2.5-10 g/kg) activity was observed against acute inflammation induced by acetic acid and in the xylene ear oedema test. In the chronic inflammation test the extract (2.5-5 g/kg) showed significant and dose-dependent antiinflammatory activity. The aqueous seed extract of S. leriifolia may therefore have supraspinal antinociceptive effects which may be mediated by opioid receptors, and showed considerable effects against acute and chronic inflammation.

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Bioactivity studies ofSalvia transsylvanica (Schur ex Griseb) grown in Egypt

Cited by 16 publications

References 7 publications

Antinociceptive Effect of Salvia Extract on Cisplatin-Induced Hyperalgesia in Mice

Antinociceptive Effect of Salvia Extract on Cisplatin-Induced Hyperalgesia in Mice

ESSENTIAL AND FIXED OIL CHEMICAL COMPOSITIONS OF THE SEEDS FROM THE ENDEMIC SPECIES Salvia Sharifii RECH. F. & ESFAND

Antinociceptive, antiinﬂammatory and acute toxicity effects of Salvia leriifolia Benth. seed extract in mice and rats

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