Bioactivity of plasma implanted biomaterials

Chu, Paul K.

doi:10.1016/j.nimb.2005.08.015

Cited by 26 publications

(10 citation statements)

References 67 publications

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“…PIII&D technique is usually applied in areas such as microelectronics, aerospace engineering and precision manufacturing. In the past 10 years, applications of PIII&D technique in biomedical implant modification have attracted increasing interest because of its controllability and versatility [26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Surface modification of biomaterials using plasma immersion ion implantation and deposition

2012

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Although remarkable progress has been made on biomaterial research, the ideal biomaterial that satisfies all the technical requirements and biological functions is not available up to now. Surface modification seems to be a more economic and efficient way to adjust existing conventional biomaterials to meet the current and ever-evolving clinical needs. From an industrial perspective, plasma immersion ion implantation and deposition (PIII&D) is an attractive method for biomaterials owing to its capability of treating objects with irregular shapes, as well as the control of coating composition. It is well acknowledged that the physico-chemical characteristics of biomaterials are the decisive factors greatly affecting the biological responses of biomaterials including bioactivity, haemocompatibility and antibacterial activity. Here, we mainly review the recent advances in surface modification of biomaterials via PIII&D technology, especially titanium alloys and polymers used for orthopaedic, dental and cardiovascular implants. Moreover, the variations of biological performances depending on the physico-chemical properties of modified biomaterials will be discussed.

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Section: Introductionmentioning

confidence: 99%

Surface modification of biomaterials using plasma immersion ion implantation and deposition

2012

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“…In order to modify the surface properties of polymers for use in biological environments and enhance the cell response by improving upon the adhesion characteristics, a vast number of techniques and methods have been developed. These techniques range from surface topography modification (7)(8)(9) to surface chemistry modification (10)(11)(12) and have given rise to the increased interest in using polymers as biomaterials (13)(14)(15)(16)(17)(18)(19)(20). Nylon 6,6, the strongest and most abrasive resistant unreinforced nylon, has been used for such biological applications as sutures, tracheal tubes and gastrointestinal segments (21).…”

Section: Introductionmentioning

confidence: 99%

Modulation of osteoblast cell response through laser surface processing of nylon 6,6

Waugh

Lawrence

2011

International Congress on Applications of Lasers &Amp; Electro-Optics

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With an ageing population demand on medical facilities is growing, especially for bio-implants. Therefore, there is a need for cheaper, more efficient implants. This paper details how CO 2 and KrF excimer lasers can be employed to modulate osteoblast cell growth on nylon 6,6 in relation to laser-modified wettability characteristics. Through patterning the contact angle, θ, increased by up to 19°, indicating the presence of a mixed state wetting regime; whereas θ decreased by up to 20° for the whole area irradiative processed samples. After 24 hours and 4 days incubation the cell cover density and cell count was somewhat modulated over the laser-modified samples compared to the as-received sample. A likely increase in surface toxicity gave rise to a hindered cell response for those samples with high energy densities and high incident pulse numbers. No strong correlations were determined for the laser-induced patterned samples which can be attributed to the likely mixed-state wetting regime. Correlative trends were found between the cell response, θ, polar component and surface oxygen content for the whole area irradiative processed samples. Thus, allowing one to identify the potential for this technology in regenerative medicine.

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“…Recent applications also include biomedical technologies [6] and arc ion plating [7]. Plasma Immersion Ion Implantation (PIII), otherwise called Plasma Source Ion Implantation (PSII), has several advantages over conventional ion beam implantation including higher ion current densities and a wider ion energy range, making it possible to treat targets of complex shapes in a rather short time [8].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the ion dose non-uniformity caused by sheath-lens focusing effect on silicon wafers

et al. 2007

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Bioactivity of plasma implanted biomaterials

Cited by 26 publications

References 67 publications

Surface modification of biomaterials using plasma immersion ion implantation and deposition

Surface modification of biomaterials using plasma immersion ion implantation and deposition

Modulation of osteoblast cell response through laser surface processing of nylon 6,6

Investigation of the ion dose non-uniformity caused by sheath-lens focusing effect on silicon wafers

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