Bioactivity of Phaeophytin a, α-Amyrin and lupeol from Brachystelma togoense Schltr

Ekalu, Abiche; Ayo, Rachael Gbekele-Oluwa; Habila, James D.; Ibrahim, H.

doi:10.18596/jotcsa.571770

Cited by 7 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Established antimicrobial effect of H. scheppigianum dried CH 2 Cl 2 extract could be at least partly linked to its previously identified triterpenes of ursane and oleane type [7] . Namely, the literature data suggest that the mixture of α ‐ and β ‐amyrin (1 : 2), as well as the mixture of their acetates are active against C. albicans ( MIC =0.125 and 0.25 mg/mL) and C. krusei ( MIC =0.03 and 0.125 mg/mL), whereas α ‐amyrin is slightly less active against S. aureus , S. Typhi and E. coli ( MIC =0.4 mg/mL; MBC =0.8 mg/mL) [23,24] . Regarding the mechanisms of antimicrobial activity, Chung [25] summarized on the example of S. aureus that α ‐amyrin exhibits activity by affecting the biosynthesis of fatty acids, peptidoglycan and nucleic acids.…”

Section: Resultsmentioning

confidence: 96%

“…[7] Namely, the literature data suggest that the mixture of αand β-amyrin (1 : 2), as well as the mixture of their acetates are active against C. albicans (MIC = 0.125 and 0.25 mg/mL) and C. krusei (MIC = 0.03 and 0.125 mg/mL), whereas α-amyrin is slightly less active against S. aureus, S. Typhi and E. coli (MIC = 0.4 mg/mL; MBC = 0.8 mg/mL). [23,24] Regarding the mechanisms of antimicrobial activity, Chung [25] summarized on the example of S. aureus that α-amyrin exhibits activity by affecting the biosynthesis of fatty acids, peptidoglycan and nucleic acids. Also, Kwun et al [26] showed on C. albicans that β-amyrin causes excessive intracellular generation of reactive oxygen species (ROS) leading to Ca 2 + dependent mitochondrial dysfunction and consequently to the cell apoptosis.…”

Section: [C]mentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones

Milutinović

Matić

Stanojković

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

Antimicrobial and cytotoxic activities were tested for dried MeOH extracts of Hieracium calophyllum (CAL), H. coloriscapum (COL), H. pseudoschenkii (PSE), H. valdepilosum (VAL) and H. glabratum (GLA) herbs (flowering aerial parts), their 2 sesquiterpene lactones (SLs) 8‐epiixerisamine A and crepiside E, and dried CH2Cl2 extract of H. scheppigianum (SCH) herb. In microdilution test, extracts showed activity on all tested microorganisms (8 bacteria, 10 fungi). The best effect was exhibited by SCH and CAL on Salmonella Typhimurium (MIC=1.7–2.5 mg/mL MBC=3.4–5.0 mg/mL), and SCH and VAL on Candida albicans (MIC=2.5 mg/mL MFC=5.0 mg/mL). SLs showed notable effect on all tested fungi Aspergillus ochraceus, Penicillium funiculosum, C. albicans and C. krusei (MIC=0.15–0.4 mg/mL MFC=0.3–0.8 mg/mL). In MTT test, extracts inhibited growth of all tested cancer cells (HeLa, LS174 and A549), with the best effect on HeLa (IC50=148.1 μg/mL for SCH, and 152.3–303.2 μg/mL for MeOH extracts); both SLs were active against HeLa cells (IC50=46.2 μg/mL for crepiside E and 103.8 μg/mL for 8‐epiixerisamine A). Extracts and SLs showed good safety profile on normal MRC‐5 cells.

show abstract

Section: Resultsmentioning

confidence: 96%

Section: [C]mentioning

confidence: 99%

Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones

Milutinović

Matić

Stanojković

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…Over 80% of people in developing countries rely on TM for primary health care needs, of which a major proportion corresponds to plant extracts (6,7). The phytochemicals isolated from these plants have shown in vitro and in vivo biological activities (8).…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents of Rumex abyssinicus Roots and Evaluation of Its Antimicrobial Activities

Shifa

Abdissa

Asere

2021

Journal of the Turkish Chemical Society Section A: Chemistry

View full text Add to dashboard Cite

Medicinal plants are usually screened for phytochemicals that may lead to further isolation, purification, and characterization of their active principles. The roots of Rumex abyssinicus are used traditionally in Ethiopia for treating different diseases such as hepatitis, hemorrhoids, gonorrhea, typhus, and wounds. Thus, this study was conducted to investigate the phytochemicals and in vitro antimicrobial activity of the roots of R. abyssinicus extracts. The roots were collected, chopped, and airdried under shade in the laboratory. Then, the dried plant material was subjected to sequential extraction using the maceration technique by soaking 1 kg of the sample in petroleum ether, chloroform, acetone, and methanol. Meanwhile, the filtrates were concentrated under reduced pressure using a rotary evaporator. Afterward, the crude extracts were dried and screened for in vitro antimicrobial activity tests using four bacterial and two fungal strains. Based on its activity, the acetone extract was used for column chromatographic isolation. Herein, two known anthraquinones were isolated and characterized: chrysophanol and emodin. The microbial activity of both extracts and isolated compounds were evaluated against medically important strains by the agar disc diffusion method. The concentration of the extracts and isolated compounds was 100 mg/mL tested against S. aureus ATCC25903, K. pneumoniae NCTC13368, E. coli ATCC 25722, P. aeruginosa DSMZ 1117 and C. albicans and S. cerevisiae. The zone of growth inhibition of extracts and isolated compounds were compared with standard drugs like Gentamycin and Mancozeb. The results showed that the isolated compounds (1 and 2) have higher bacterial growth inhibition than the extracts. However, compound 2 was not active against S. cerevisiae strain.

show abstract

Phytochemical composition, bioactive properties, and toxicological profile of Tetrapleura tetraptera

Anyamele

Onwuegbuchu

Ugbogu

et al. 2023

Bioorganic Chemistry

View full text Add to dashboard Cite

Bioactivity of Phaeophytin a, α-Amyrin and lupeol from Brachystelma togoense Schltr

Cited by 7 publications

References 13 publications

Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones

Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones

Chemical Constituents of Rumex abyssinicus Roots and Evaluation of Its Antimicrobial Activities

Phytochemical composition, bioactive properties, and toxicological profile of Tetrapleura tetraptera

Contact Info

Product

Resources

About