Bioactivity of calcium phosphate bioceramic coating fabricated by laser cladding

Abstract

There were always strong expectations for suitable biomaterials used for bone regeneration. In this study, to improve the biocompatiblity of titanium alloy, calcium phosphate bioceramic coating was obtained by laser cladding technology. The microstructure, phases, bioactivity, cell differentiation, morphology and resorption lacunae were investigated by optical microscope (OM), x-ray diffraction (XRD), methyl thiazolyl tetrazolium (MTT) assay, tartrate-resistant acid phosphatase (TRAP) staining and scanning electronic microscope (SEM), respectively. The results show that bioceramic coating consists of three layers, which are a substrate, an alloyed layer and a ceramic layer. Bioactive phases of β-tricalcium phosphate (β-TCP) and hydroxyapatite (HA) were found in ceramic coating. Osteoclast precursors have excellent proliferation on the bioceramic surface. The bioceramics coating could be digested by osteoclasts, which led to the resorption lacunae formed on its surface. It revealed that the gradient bioceramic coating has an excellent bioactivity.

Study on microstructure, microhardness, bioactivity, and biocompatibility of La2O3‐containing bioceramic coating doping SiO2 fabricated by laser cladding

“…Based on our previous work (Zhang et al, 2018;Zhu et al, 2016), the optimized technological parameter is as follows: Output of power p = 1.8 kW; Scanning velocity V = 240 mmÁmin −1 ; Laser beam size D = 4 mm. The first gradient layer powders (thickness: 0.5 mm) were coated on Ti alloy by laser cladding according to the above parameters.…”

“…Among these techniques, laser cladding has broad application prospects in the biomedical field because of the advantages such as rapid melting and ultra-fast cooling (Jiang et al, 2015;Shepeleva et al, 2000). In our previous work, a kind of gradient calciumphosphate (Ca-P) bioceramic coating was successfully fabricated by laser cladding on Ti-6Al-4 V (Liu, Li, & Yang, 2007;Liu, Ling, & Yang, 2000;Liu, Zhu, Zou, Zheng, & Dong, 2005;Zhang, Liu, Li, Bai, & Yang, 2018;Zhu et al, 2016). It is found bioactive phases such as HA and TCP were catalyzed in the process of laser cladding when dopping La 2 O 3 .…”

Inhibition of osteoclast activities by SCPC bioceramic promotes osteoblast‐mediated graft resorption and osteogenic differentiation

“…It could be argued that osteoclastic dissolution of calcium phosphate ceramic releases calcium ions, which have a stimulatory effect on osteoblasts. However, the released calcium ions also stimulate osteoclasts differentiation 22 . The competition between osteoclasts and osteoblasts on the limited amount of calcium slows down the remodeling and maturation of the newly formed bone.…”

Effect of doping different Si source on Ca-P bioceramic coating fabricated by laser cladding

“…In our previous studies, La 2 O 3 -doped Ca-P coating was fabricated by using the method of laser cladding on Ti alloy. [18][19][20][21][22] Bioactive phases tricalcium-phosphate (TCP) and HA were obviously catalyzed by La 2 O 3 during laser cladding process, while there is almost no TCP and HA in the coating doped without La 2 O 3 . In the electronic structure of the La atom the D5 rail is empty, which provides an electron transfer orbit and can be used as an electron transfer catalysis "station" so that La 2 O 3 has high catalytic activity.…”