Bioactivity of a flavanol‐rich lychee fruit extract in adipocytes and its effects on oxidant defense and indices of metabolic syndrome in animal models

Kalgaonkar, Swati; Nishioka, Hiroshi; Gross, Heidrun B.; Fujii, H.; Keen, Carl L.; Hackman, Robert M.

doi:10.1002/ptr.3137

Cited by 14 publications

(13 citation statements)

References 30 publications

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“…EGCG dose-dependently increased PGI2 production in bovine endothelial cells [36]. Flavan-3-ols from fruits improved indices of MetS in animal models [37], but more studies examining flavan-3-ols from fruits are needed.…”

Section: Discussionmentioning

confidence: 99%

Dietary flavan-3-ols intake and metabolic syndrome risk in Korean adults

Yang

Kim

et al. 2012

Nutr Res Pract

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Flavan-3-ols are a subclass of flavonoids found in a variety of foods including teas. The effects of flavan-3-ols on the risk of metabolic syndrome (MetS) have been investigated, generally focusing on tea catechins or individual flavan-3-ol rich foods, but there is little information on dietary flavan-3-ols intake and risk of MetS in population-based studies. In this cross-sectional study, we examined the association between dietary flavan-3-ols intake and the risk of MetS in Korean adults. Subjects comprised 1,827 men and 2,918 women aged 20-69 years whose data was included in the 2008 Korean National Health and Nutrition Examination Survey. This survey was conducted between January 2008 and December 2008. Total flavan-3-ols intakes were calculated from 24-hour dietary recalls using a flavonoids database. Thirty percent of the male subjects and 24% of the female subjects were reported as having MetS. In the female subjects, flavan3-ols intake was inversely associated with the risk of MetS after adjusting for potential confounders (5th vs. 1st quintile, OR = 0.64, 95% CI = 0.45-0.91, P for trend = 0.384). The main food source of flavan-3-ols was green tea followed by apples and grapes. Among MetS components, flavan3-ols intake was inversely associated with the risk of high blood pressure after adjusting for potential confounders (5th vs. 1st quintile, OR = 0.64, 95% CI = 0.45-0.90, P for trend = 0.005). No significant association between flavan-3-ols intake and risk of MetS was found in the male subjects. After stratified analysis by obesity (BMI ≥ 25 or BMI < 25), however, flavan3-ols intake was inversely related to the risk of hypertension in non-obese men. These results suggest that dietary flavan-3-ols intake may have beneficial effects on MetS risk by reducing the risk of hypertension. The effects of flavan-3-ols intake dependent on obesity need further investigation.

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Section: Discussionmentioning

confidence: 99%

Dietary flavan-3-ols intake and metabolic syndrome risk in Korean adults

Yang

Kim

et al. 2012

Nutr Res Pract

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“…FRLFE (Oligonol ® , Amino Up Chemical Co., Ltd, Sapporo Japan) was used in this study. FRLFE contained 16.3% monomers [8.2% (+)‐catechin and (–)‐epicatechin; 2.1% epicatechin gallate; 6% EGCG], 13.8% dimers [5% procyanidin A2; 4.1% procyanidin A1; 3.1% procyanidin B2; 1.6% other dimers], 3.8% trimers and 58.6% larger proanthocyanidins (Kalgaonkar et al , ; Miura et al , ). Each FRLFE capsule contained FRLFE (50 mg) and dextrin (150 mg).…”

Section: Methodsmentioning

confidence: 99%

Supplementation with a Flavanol‐rich Lychee Fruit Extract Influences the Inflammatory Status of Young Athletes

Nishizawa

Hara

Miura

et al. 2011

Phytotherapy Research

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Flavanol-rich lychee fruit extract (FRLFE) is a processed lychee fruit extract that is higher in flavanols (monomers, dimers and trimers) than its unprocessed counterpart. FRLFE exerts antioxidant activities in vitro and is expected to protect against inflammation and tissue damage. However, the physiological effects of FRLFE intake have not been explored in vivo. The aim of this study was to examine the effects of FRLFE supplementation on inflammation and tissue damage in young athletes during intense physical training. Twenty healthy male long-distance runners at a university were randomly assigned to receive FRLFE or placebo in a double-blind manner. Blood and serum parameters associated with inflammation, tissue damage and oxidative stress were evaluated before (pre-training), during (mid-training) and after (post-training) a 2-month training period. Some parameters, including the white blood cell count, were significantly modified by FRLFE supplementation. Compared with the placebo group, the change in the serum interleukin-6 level between pre- and mid-training were significantly lower in the FRLFE group, while the change in the transforming growth factor-β level between pre- and post-training was significantly greater in the FRLFE group. These findings suggest that FRLFE supplementation may suppress inflammation or tissue damage caused by high-intensity exercise training.

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“…Lychee is one such plant that claims to possess liver tonic activity, hence, was selected with the aim of establishing a scientific basis for its traditional claim. The plant has already been investigated for its nutritive composition (Wu et al, 2009;Kalgaonkar et al, 2010), anti-inflammatory (Besra et al, 1996) and antioxidant (Yang et al, 2006;Li and Jiang, 2007;Sakurai et al, 2008;Kong et al, 2010) activities. It has one of the highest reported polyphenol concentrations of any fruit (Brat et al, 2006).…”

Section: Introductionmentioning

confidence: 99%