Bioactivity guided isolation and structural characterization of the antidiabetic and antioxidant compound from bark extract of Avicennia officinalis L

Das, Swagat Kumar; Samantaray, Dibyajyoti; Sahoo, Sudhir Kumar; Patra, Jayanta Kumar; Samanta, Luna; Thatoi, Hrudayanath

doi:10.1016/j.sajb.2019.07.011

Cited by 12 publications

(10 citation statements)

References 14 publications

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“…Numerous studies have examined various plant extracts, and the secondary metabolites found in plants may have the potential to treat SARS-CoV-2 [ 15 ]. Avicennia officinalis is a popular evergreen medicinal mangrove plant found in Bangladesh, and this species can also be found in Europe, Western Asia, and North Africa [ 16 ]. Commonly known as Bain or Indian mangrove, A. officinalis has various medicinal effects, including antidiabetic, anti-inflammatory, anticancer, antioxidant, and antimicrobial properties [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Phytochemicals Derived from Avicennia officinalis for the Management of COVID-19: A Combined In Silico and Biochemical Study

et al. 2021

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The recent coronavirus disease 2019 (COVID-19) pandemic is a global threat for healthcare management and the economic system, and effective treatments against the pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus responsible for this disease have not yet progressed beyond the developmental phases. As drug refinement and vaccine progression require enormously broad investments of time, alternative strategies are urgently needed. In this study, we examined phytochemicals extracted from Avicennia officinalis and evaluated their potential effects against the main protease of SARS-CoV-2. The antioxidant activities of A. officinalis leaf and fruit extracts at 150 µg/mL were 95.97% and 92.48%, respectively. Furthermore, both extracts displayed low cytotoxicity levels against Artemia salina. The gas chromatography–mass spectroscopy analysis confirmed the identifies of 75 phytochemicals from both extracts, and four potent compounds, triacontane, hexacosane, methyl linoleate, and methyl palminoleate, had binding free energy values of −6.75, −6.7, −6.3, and −6.3 Kcal/mol, respectively, in complexes with the SARS-CoV-2 main protease. The active residues Cys145, Met165, Glu166, Gln189, and Arg188 in the main protease formed non-bonded interactions with the screened compounds. The root-mean-square difference (RMSD), root-mean-square fluctuations (RMSF), radius of gyration (Rg), solvent-accessible surface area (SASA), and hydrogen bond data from a molecular dynamics simulation study confirmed the docked complexes′ binding rigidity in the atomistic simulated environment. However, this study′s findings require in vitro and in vivo validation to ensure the possible inhibitory effects and pharmacological efficacy of the identified compounds.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Phytochemicals Derived from Avicennia officinalis for the Management of COVID-19: A Combined In Silico and Biochemical Study

et al. 2021

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“…Basak et al [23] were the first to estimate the contents of carotenoids, proteins, and secondary metabolites in the leaves of 14 mangrove species from this National park. Das et al [24,25] have made preliminary phytochemical screening of the bark and leaf extracts of A. officinalis and revealed the presence of steroids, flavonoids, tannins, and phenolics. Preliminary characterization of phytochemicals were also made for crude extracts of the plant parts of Heritiera fomes, [26,27] S. apetala, [28,29] and E. agallocha.…”

Section: Phytochemicals From Dominant Mangroves Of Bhitarkanika Natio...mentioning

confidence: 99%

“…Only a few mangroves were evaluated for their biological activities related to their primary or secondary metabolites. Antioxidant, anti-microbial, antidiabetic, and anticancer properties are the most common bioactivity assays performed with crude extracts of Avicennia officinalis, [25] Excoecaria agallocha, [30,32] Heritiera fomes, [26,27] and Sonneratia apetala. [29] Green synthesized silver and zinc nanoparticles from the plant extracts of A. officinalis, H. fomes and S. apetala were also revealed significant bioactivity.…”

Section: Therapeutic Potential Of Mangroves Of Bhitarkanika National ...mentioning

confidence: 99%

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

Das

Jena

et al. 2022

Chemistry & Biodiversity

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Bhitarkanika National Park is the second largest contiguous mangrove forest of India. Approximately 0.15 million mangrove depending population are found residing in and around 307 villages within the National Park. Despite being one of the most diverse mangrove habitations of India, the ethnopharmacological practices are meager in comparison to the other mangrove regions of India and Southeast Asia. The present review is aimed to congregate information on the therapeutic potential and ethnopharmacology of nine dominant mangrove species of the National Park, such as Aegiceras corniculatum, Avicenia marina, Avicenia officinalis, Ceriops decandra, Excoecaria agallocha, Heritiera fomes, Lumnitzera racemosa, Rhizophora mucronata, and Sonneratia apetala. Our aim is to generate social awareness among the mangrove dwellers to promote uses of folklore medicine using these tremendously potential mangrove plants, as a complementary step to strengthen community health. Further, we also want to grab the attention of researchers working in related disciplines, for their holistic and extensive studies towards bio-prospectation of the dominant mangrove plants of Bhitarkanika National Park.

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“…Besides, the blood glucose level, it has also shown to lower the total cholesterol, triglyceride, liver toxicity markers (SGOT and SGPT), and urea levels. [59] The petroleum ether and aqueous extracts of leaves were also evaluated for in vitro antidiabetic activity by α-amylase and α-glucosidase assays, where aqueous extract (1 mg/mL) was found to be more effective than crude petroleum ether extract. [60]…”

Section: Antidiabetic Activitymentioning

confidence: 99%

“…[13,74] The ethanol bark and leaf extracts exhibit a dose-dependent scavenging potential against ABTS, DPPH, and superoxide radicals with IC 50 values ranging from 82 to 207.6 µg/mL, [66] the petroleum ether and aqueous extracts of leaves also demonstrate antioxidant capacity in DPPH, superoxide, and hydrogen peroxide scavenging assays with IC 50 values ranging from 0.17 to 0.27 mg/mL for the extracts. [57,59,60]…”

Section: Anti-nociceptive Analgesic and Antipyretic Activitiesmentioning

confidence: 99%

Untitled

Shah¹

2021

IJGP

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Introduction:The genus of Avicennia consists of total eight species which survive at intertidal zones from tropical and temperate regions of world, the foremost species being Avicennia officinalis and Avicennia marina. The plants belonging to this genus have both therapeutic and economic (industrial) benefits. Among all the species, A. officinalis is an important Indian mangrove differentiated greatly by its antibacterial and anticancer activities. This article is an effort to compile all the essential information of A. officinalis in a comprehensive manner, including pharmacognostic features, traditional and ethnomedicinal uses, phytochemistry, and pharmacological activities of the plant. Materials and Methods: All the information regarding traditional aspects and modern studies of A. officinalis were gathered through a massive literature survey of traditional and Ayurvedic books along with scientific resources. Results and Discussion: Different parts of A. officinalis have traditional medicinal applications for the treatment of various diseases such as cancer, rheumatism, diarrhea, ulcer, Alzheimer and bacterial, fungal, and viral infections. Laboratory investigations so far have resulted in isolation and identification of more than fifty bioactive compounds from different parts of the plant majorly targeting antibacterial activity. The phytochemicals reported as characteristic constituents of this plant are flavanoids, steroids, terpenoids with polyisoprenoids, and tannins. Further, records appertaining pharmacological evaluation have revealed significant activities such as antioxidant, anticarcinogenic, antidiabetic, antiviral, and many more. Conclusion: The article summarizes the diversity and distribution of A. officinalis, in addition to in-depth coverage of traditional medicinal usage and phyto-pharmacological investigations done on this medicinal plant so far, highlighting the need for further studies on the phytoconstituents responsible for the validated traditional and folklore claims of its enormous medicinal usage.

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Bioactivity guided isolation and structural characterization of the antidiabetic and antioxidant compound from bark extract of Avicennia officinalis L

Cited by 12 publications

References 14 publications

Efficacy of Phytochemicals Derived from Avicennia officinalis for the Management of COVID-19: A Combined In Silico and Biochemical Study

Efficacy of Phytochemicals Derived from Avicennia officinalis for the Management of COVID-19: A Combined In Silico and Biochemical Study

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

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