Bioactivity and mechanisms of flavonoids in decreasing insulin resistance

Zhou, Min; Konigsberg, William H.; Hao, Canhua; Pan, Yinbo; Sun, Jie; Wang, Xiaojing

doi:10.1080/14756366.2023.2199168

Cited by 7 publications

(3 citation statements)

References 125 publications

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“…[20] Flavonoids, being the most abundantly occurring and extensively studied among the polyphenols, demonstrate considerable potential in treating NAFLD due to their inherent safety, widespread availability, and diverse biological activities. [21][22][23] The flavonoids identified in this study, namely, quercetin, kaempferol, and naringenin, offer promising advantages in NAFLD treatment through various mechanisms, which is consistent with findings from other studies. [24] Many in vivo and in vitro experimental evidence have identified various molecular mechanisms of quercetin in preventing the occurrence and progress of NAFLD, including antioxidant stress, anti-inflammatory, improving fatty acid metabolism, and regulating gut microbiota and bile acid metabolism.…”

Section: Discussionsupporting

confidence: 91%

Network pharmacological analysis on the mechanism of Linggui Zhugan decoction for nonalcoholic fatty liver disease

Gao,

Wei,

Qin

et al. 2024

Medicine

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Nonalcoholic fatty liver disease (NAFLD), represents a chronic progressive disease that imposes a significant burden on patients and the healthcare system. Linggui Zhugan decoction (LGZGD) plays a substantial role in treating NAFLD, but its exact molecular mechanism is unknown. Using network pharmacology, this study aimed to investigate the mechanism of action of LGZGD in treating NAFLD. Active ingredients and targets were identified through the integration of data from the TCMSP, GEO, GeneCards, and OMIM databases. Cytoscape 3.9.1 software, in conjunction with the STRING platform, was employed to construct network diagrams and screen core targets. The enrichment analysis of gene ontology and the Kyoto Encyclopedia of Genes and Genomes pathways were conducted by using the R. Molecular docking of the active ingredients and core targets was performed with AutoDock Vina software. We obtained 93 and 112 active ingredients and potential targets using the bioinformatic analysis of LGZGD in treating NAFLD. The primary ingredients of LGZGD included quercetin, kaempferol, and naringenin. The core targets were identified AKT1, MYC, HSP90AA1, HIF1A, ESR1, TP53, and STAT3. Gene ontology function enrichment analysis revealed associations with responses to nutrient and oxygen levels, nuclear receptor activity, and ligand-activated transcription factor activity. Kyoto Encyclopedia of Genes and Genomes signaling pathway analysis implicated the involvement of the PI3K-Akt, IL-17, TNF, Th17 cell differentiation, HIF-1, and TLR signaling pathways. Molecular docking studies indicated strong binding affinities between active ingredients and targets. LGZGD intervenes in NAFLD through a multi-ingredient, multi-target, and multi-pathway approach. Treatment with LGZGD can improve insulin resistance, oxidative stress, inflammation, and lipid metabolism associated with NAFLD.

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Section: Discussionsupporting

confidence: 91%

Network pharmacological analysis on the mechanism of Linggui Zhugan decoction for nonalcoholic fatty liver disease

Gao,

Wei,

Qin

et al. 2024

Medicine

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show abstract

“…Therefore, the consumption of flavonoids as nutraceuticals requires more clinical trials to demonstrate their clinical value in metabolic syndrome treatments. While flavonoid compounds have demonstrated beneficial impacts on insulin resistance, plasma glucose reduction, the enhancement of the lipids profile, and cardiovascular protection in animal models and in vitro experiments, further clinical trials and in vivo experiments are required to confirm their efficacy [55].…”

Section: Discussionmentioning

confidence: 99%

Plasma Carotenoids and Polyphenols and Their Association with MetS: The Need for Nutritional Interventions

et al. 2023

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Metabolic syndrome (MetS) is characterized by increased pro-oxidative stress and a chronic inflammation state and their consequent alterations. Several studies have highlighted the protective effect of carotenoids and polyphenols in MetS patients. This study aimed to evaluate the plasma level of selected carotenoids and polyphenols and to determine their relationship with MetS severity, MetS components, and inflammatory markers in Polish adults with metabolic disorders. It was designed as a cross-sectional study. The final study group comprised 275 adults, including 158 women and 117 men. Data were collected on the frequency of consumption of selected food groups. Anthropometric measurements and blood samples were taken to determine the concentration of carotenoids, polyphenols, and indicators (parameters) of metabolic disorders. Plasma concentrations of selected carotenoids and polyphenols were low in adults with MetS. The highest concentrations of carotenoids and polyphenols in the blood were observed for lutein and phenolic acids (including gallic and p-coumaric acids). Nevertheless, a correlation was found between the individual bioactive compounds and MetS components. In terms of the lipid profile, our study showed that the plasma of the selected carotenoids and polyphenols positively correlated with HDL cholesterol (zeaxanthin; total carotenoids), LDL cholesterol (chlorogenic acid), triglycerides (lycopene), and the total cholesterol (kaempferol). We found that the level of CRP as a marker of inflammation negatively correlated with the concentration of zeaxanthin. In our study group, no relationship was found between the dietary antioxidant intensity and the variables studied, which may be attributed to the low frequency of consumption of the sources of bioactive compounds, such as carotenoids and polyphenols, but also to the metabolic disorders. Further research is needed to determine whether these associations are causally related to the metabolic syndrome or are a result of the pathologies of the syndrome or improper diet with a low intake of vegetables and fruit.

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“…It is an illness with a complicated etiology that affects several body organs. Flavonoids' wide range of pharmacological effects have made them a popular research subject for natural hypoglycemic medications [152]. Fisetin was discovered to be able to suppress the expression of the genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase), which are the key enzymes of hepatic gluconeogenesis, in order to maintain glucose homeostasis and improve insulin resistance.…”

Section: Antidiabetic Effectmentioning

confidence: 99%

Advances in Flavonoid Research: Sources, Biological Activities, and Developmental Prospectives

Hao,

Yang,

Liu

et al. 2024

CIMB

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At present, the occurrence of a large number of infectious and non-communicable diseases poses a serious threat to human health as well as to drug development for the treatment of these diseases. One of the most significant challenges is finding new drug candidates that are therapeutically effective and have few or no side effects. In this respect, the active compounds in medicinal plants, especially flavonoids, are potentially useful compounds with a wide range of pharmacological activities. They are naturally present in nature and valuable in the treatment of many infectious and non-communicable diseases. Flavonoids are divided into fourteen categories and are mainly derived from plant extraction, chemical synthesis and structural modification, and biosynthesis. The structural modification of flavonoids is an important way to discover new drugs, but biosynthesis is currently considered the most promising research direction with the potential to revolutionize the new production pipeline in the synthesis of flavonoids. However, relevant problems such as metabolic pathway analyses and cell synthesis protocols for flavonoids need to be addressed on an urgent basis. In the present review, new research techniques for assessing the biological activities of flavonoids and the mechanisms of their biological activities are elucidated and their modes of interaction with other drugs are described. Moreover, novel drug delivery systems, such as nanoparticles, bioparticles, colloidals, etc., are gradually becoming new means of addressing the issues of poor hydrophilicity, lipophilicity, poor chemical stability, and low bioavailability of flavonoids. The present review summarizes the latest research progress on flavonoids, existing problems with their therapeutic efficacy, and how these issues can be solved with the research on flavonoids.

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Bioactivity and mechanisms of flavonoids in decreasing insulin resistance

Cited by 7 publications

References 125 publications

Network pharmacological analysis on the mechanism of Linggui Zhugan decoction for nonalcoholic fatty liver disease

Network pharmacological analysis on the mechanism of Linggui Zhugan decoction for nonalcoholic fatty liver disease

Plasma Carotenoids and Polyphenols and Their Association with MetS: The Need for Nutritional Interventions

Advances in Flavonoid Research: Sources, Biological Activities, and Developmental Prospectives

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