Bioactivity and Drug Release Study of Dexamethasone Loaded Bioglass/Chitosan Composites for Biomedical Applications

Raboh, Ahmed. S. Abd; El-khooly, M. S.; Hassaan, M. Y.

doi:10.1007/s10904-021-01936-z

Cited by 14 publications

(10 citation statements)

References 28 publications

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“…The characteristics of bioactive glass can be enhanced and drug release patterns can be changed when polymers are utilized in bioactive glass/polymer composites [6]. Due to the widespread usage of dexamethasone as anti-inflammatory medicine, we attempted to create a novel drug delivery system based on (chitosan and bioglass) [7].…”

Section: Introductionmentioning

confidence: 99%

Drug Delivery of Corticosteroids

El-khooly¹

2023

Updates on Corticosteroids

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In this chapter, we will study how we were able to place drugs from the family of corticosteroids in the places where the drug is intended to be affected during the surgery. It was also possible to control the release of accumulated quantities of dexamethasone by coating it with some soluble polymers such as chitosan. We used samples of bioglass grafted with chitosan polymer to which different percentages of dexamethasone (Dexa) were added (5, 10, and 15%). In addition, the cumulative doses emitted from the samples were calculated by means of statistical functions and using the ultraviolet device. This was also tested on the plasma fluid of the human-simulating body fluid (SBF), and it was confirmed that the appropriate amounts of Dexa were emitted over a period of (1, 2, 4, 8, 16, 21, and 33) days. Due to its shown efficacy in simulating in liquid of the human body (SBF), we aim to put it within the human body as soon as feasible.

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Section: Introductionmentioning

confidence: 99%

Drug Delivery of Corticosteroids

El-khooly¹

2023

Updates on Corticosteroids

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“…The second generation of biomaterial like bioactive glass has good bioactivity, biocompatibility, and biodegradability [1][2][3]. They have bone-bonding ability via the formation of a hydroxyapatite layer on their surface and induce angiogenesis [4,5].…”

Section: Introductionmentioning

confidence: 99%

Bioactivity and Mechanical Properties Characterization of Bioactive Glass Incorporated with Graphene Oxide

El-khooly

Abdraboh

Bakr

et al. 2022

Silicon

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In this study, the bioactivity and the mechanical properties (Mechanical compressive strength, Hardness, and density) of bioglass (BG) and bioglass/graphene oxide (BG/GO) were investigated. Bioglass in chemical composition [60SiO2_35CaO_5P2O5] was prepared via the sol–gel method. GO was added to the bioglass (BG) with different contents (0.5, 1, 2, and 3) wt.% named as 0.5%GO, 1%GO, 2%GO, and 3%GO samples respectively. The synthesized specimens were characterized by several techniques Fourier Transform Infrared (FT-IR), X-Ray Diffraction (XRD), and Scanning Electron Microscopy (SEM). Compressive strength, Hardness, and density were studied also by different techniques to obtain the optimum Mechanical samples. The biological activity was studied by an in-vitro test in simulated body fluid (SBF) for 33 days. Results showed that: the 0.5%GO sample exhibited optimum mechanical compressive strength by approximately 82% compared to the BG sample. Hardness was increased from 0.5%GO sample up to 1%GO sample compared to BG sample and gradually decreased in 2%GO Sample and 3%GO. Bioactivity results showed deposition of HA layer on the bioglass surface and there was no significant change in it with the addition of graphene oxide.

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“…It is more highlighted when the release rate (and the bioavailability) of a drug is very high; while, the half‐life of that and the required dosage for body is low [2] . There are several methods designed to regulate the release rate of the drugs such as slow release tablets, [3] osmotic pumps, [4] sol‐gels, [5] and molecular imprinted polymer (MIPs) [6] …”

Section: Introductionmentioning

confidence: 99%

“…It is more highlighted when the release rate (and the bioavailability) of a drug is very high; while, the half-life of that and the required dosage for body is low. [2] There are several methods designed to regulate the release rate of the drugs such as slow release tablets, [3] osmotic pumps, [4] sol-gels, [5] and molecular imprinted polymer (MIPs). [6] The MIPs which are of the best achievements of the molecular imprinting technique (MIT), have recently been developed as suitable candidates for drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a New Molecular Imprinted Polymer for Oxycodone Opioid and Its Formulation for Transdermal Controlled Drug Delivery Application: A Joint Experimental and Quantum Chemical Study

et al. 2022

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In the present project, a molecular imprinted polymer (MIP) was synthesized by using oxycodone (as the molecular template as well as the guest drug). The precipitation polymerization approach was used for preparation of the nano‐composites. Methacrylic acid (MAA), ethylene glycol dimethacrylate (EGDMA), and 2,2‐azobisissobutyronitrile (AIBN), were used as the functional monomer, the crosslinker, and as the photoinitiator, respectively. Moreover, to decrease the release rate of the drug, the bacterial cellulose (BC) was used in formulation of MIP contained‐transdermal patch. The release study of the drug by high performance liquid chromatography (HPLC) system (fitted with the Higuchi expression) has indicated that the MIP‐BC is a good candidate for the controlled transdermal drug delivery systems (TDDS). Finally, both the MIP‐, and the non‐molecular imprinted polymers (NIP)‐drug systems were designed and studied by the density functional theory (DFT) quantum chemical method, to investigate the potential energy surface (PES), structural properties, and adsorption behavior in the molecular view. The results showed that the formation of MIP‐oxycodone (−12.85 kcal mol−1) system is more favorable than the formation of the NIP‐oxycodone one (−11.35 kcal mol−1) (due to more hydrogen bonds, and polar interactions).

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Bioactivity and Drug Release Study of Dexamethasone Loaded Bioglass/Chitosan Composites for Biomedical Applications

Cited by 14 publications

References 28 publications

Drug Delivery of Corticosteroids

Drug Delivery of Corticosteroids

Bioactivity and Mechanical Properties Characterization of Bioactive Glass Incorporated with Graphene Oxide

Synthesis of a New Molecular Imprinted Polymer for Oxycodone Opioid and Its Formulation for Transdermal Controlled Drug Delivery Application: A Joint Experimental and Quantum Chemical Study

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