Bioactivity and antibacterial properties of calcium- and silver-doped coatings on 3D printed titanium scaffolds

Rodríguez-Contreras, Adrián; Torres, D; Rafik, Belal; Ortiz-Hernández, Mónica; Ginebra, Maria Pau; Calero, Jorge; Manero, José María; Rupérez, Elisa

doi:10.1016/j.surfcoat.2021.127476

Cited by 22 publications

(13 citation statements)

References 58 publications

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“…There are many different recent reports on the modification of 3D printed scaffolds with metallic NPs for antibacterial applications. − These methods require multiple steps and need different reagents to form/add metallic NP coatings on the surface of 3D scaffolds and therefore cannot be applied to all the different hydrophobic and hydrophilic 3D printed scaffolds. In comparison with all these recent approaches to nanostructure metallic NPs on 3D scaffolds, our PER process is a robust, safe, and scalable method which can be applied to modify the surface of any 3D printed scaffolds, regardless of any of its properties.…”

Section: Resultsmentioning

confidence: 99%

Plasma Electroless Reduction: A Green Process for Designing Metallic Nanostructure Interfaces onto Polymeric Surfaces and 3D Scaffolds

Vijayan

Walker

Pillai

et al. 2022

ACS Appl. Mater. Interfaces

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The design of metal nanoparticle-modified polymer surfaces in a green and scalable way is both desirable and highly challenging. Herein, a new green low-temperature plasma-based in situ surface reduction strategy termed plasma electroless reduction (PER) is reported for achieving in situ metallic nanostructuring on polymer surfaces. Proof of concept for this new method was first demonstrated on hydrophilic cellulose papers. Cellulose papers were dip-coated with different metal ion (Ag + and Au 3+ ) solutions and then subjected to hydrogen plasma treatment for this PER process. Transmission electron microscopy (TEM) analysis has revealed that this PER process caused anisotropic growth of either gold or silver nanoparticles, resulting in the time-dependent formation of both distinct spherical nanoparticles (∼20 nm) and anisotropic 2D nanosheets. Furthermore, we have demonstrated the adaptability of this process by applying it to hydrophobic fibrous and 3D printed polymeric materials such as surgical face masks and 3D printed polylactic acid scaffolds. The PER process on these hydrophobic polymer surfaces was accomplished via a sequential combination of air plasma and hydrogen plasma treatment. The metallic nanostructuring caused by the PER process on these hydrophobic surfaces was systematically studied using different surface imaging techniques including 3D confocal laser surface scanning microscopy and scanning electron microscopy. We have also systematically optimized the PER process on the surface of 3D scaffolds via varying the concentration of the silver ion precursor and by different postprocessing methods such as sonication and medium soaking. These optimization processes were found to be very important in generating uniform metallic nanoparticle-modified 3D printed scaffolds while simultaneously improving cytocompatibility. Through joint disk diffusion and inhibitory concentration testing, the antibacterial efficacy of silver coatings on face masks and 3D scaffolds was established. Altogether, these results clearly suggest the excellent futuristic potential of this new PER method for designing metallic nanostructured interfaces for different biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Plasma Electroless Reduction: A Green Process for Designing Metallic Nanostructure Interfaces onto Polymeric Surfaces and 3D Scaffolds

Vijayan

Walker

Pillai

et al. 2022

ACS Appl. Mater. Interfaces

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“…On the other hand, the disassociation metal ions (Ag + ) leaching out from the surface holds the ability to target sulfur-containing biomolecules via cell membrane penetration. 141 4.1.2 Photothermal killing. The adherence and colonization of planktonic bacterial pathogens on the inert surface of the implant were inevitable and caused severe issues in clinical applications.…”

Section: Antibacterial/antibiofilm Propertiesmentioning

confidence: 99%

“…On the other hand, the disassociation metal ions (Ag + ) leaching out from the surface holds the ability to target sulfur-containing biomolecules via cell membrane penetration. 141…”

Section: Biomedical Perspective Of Ta Coatingsmentioning

confidence: 99%

Recent progress in tannic acid-driven antibacterial/antifouling surface coating strategies

et al. 2022

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“…21,22 Hence, researchers have attempted to modulate the implant properties by various techniques to make the surface antibacterial for different bacteria species. Implant surfaces doped with varying amounts of bactericidal materials such as silver, copper and zinc have been investigated, [23][24][25] however the major limitation is that these ions may diffuse into the surrounding tissues over time causing toxicity and necrosis. 26 Photocatalytic materials have been shown to have antibacterial properties when exposed to UV light, 27,28 however, these materials have shown poor long-term stability.…”

Section: Introductionmentioning

confidence: 99%

Enhanced antibacterial properties on superhydrophobic micro‐nano structured titanium surface

Manivasagam

Perumal

Arora

et al. 2022

J Biomedical Materials Res

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Micro/nano scale surface modifications of titanium based orthopedic and cardiovascular implants has shown to augment biocompatibility. However, bacterial infection remains a serious concern for implant failure, aggravated by increasing antibiotic resistance and over usage of antibiotics. Bacteria cell adhesion on implant surface leads to colonization and biofilm formation resulting in morbidity and mortality. Hence, there is a need to develop new implant surfaces with high antibacterial properties. Recent developments have shown that superhydrophobic surfaces prevent protein and bacteria cell adhesion. In this study, a thermochemical treatment was used modify the surface properties for high efficacy antibacterial activity on titanium surface. The modification led to a micro‐nano surface topography and upon modification with polyethylene glycol (PEG) and silane the surfaces were superhydrophilic and superhydrophobic, respectively. The modified surfaces were characterized for morphology, wettability, chemistry, corrosion resistance and surface charge. The antibacterial capability was characterized with Staphylococcus aureus and Escherichia coli by evaluating the bacteria cell inhibition, adhesion kinetics, and biofilm formation. The results indicated that the superhydrophobic micro‐nano structured titanium surface reduced bacteria cell adhesion significantly (>90%) and prevented biofilm formation compared to the unmodified titanium surface after 24 h of incubation.

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Bioactivity and antibacterial properties of calcium- and silver-doped coatings on 3D printed titanium scaffolds

Cited by 22 publications

References 58 publications

Plasma Electroless Reduction: A Green Process for Designing Metallic Nanostructure Interfaces onto Polymeric Surfaces and 3D Scaffolds

Plasma Electroless Reduction: A Green Process for Designing Metallic Nanostructure Interfaces onto Polymeric Surfaces and 3D Scaffolds

Recent progress in tannic acid-driven antibacterial/antifouling surface coating strategies

Enhanced antibacterial properties on superhydrophobic micro‐nano structured titanium surface

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