Bioactivities of Salvia nemorosa L. inflorescences are influenced by the extraction solvents

Ivanov, Marija; Božunović, Jelena; Gašić, Uroš; Drakulić, Danijela; Stevanović, Milena; Rajčević, Nemanja; Stojković, Dejan

doi:10.1016/j.indcrop.2021.114260

Cited by 10 publications

(13 citation statements)

References 58 publications

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“…The yields of the extracts E10, EW7.5, EW5, EW2.5, W10, B10, BE7.5, BE5 and BE2.5 are presented in Table 1 . The influence of different extraction solvents on biological activity and chemical composition was previously reported for other plant species [ 23 ].…”

Section: Resultsmentioning

confidence: 93%

“…The effect of A. scorodprasum flower extracts on viability was tested in a HaCaT cell model. HaCaT cells are a human immortalized keratinocyte cell line that is frequently used in assays elucidating the safety of newly designed natural products [ 23 , 36 ]. It is evident from Figure 1 that all of the tested extracts of A. scorodoprasum did not induce significant changes in the viability of HaCaT cells when compared to the control non-treated cells.…”

Section: Resultsmentioning

confidence: 99%

“…A Syncronis C18 aqua analytical column (100 × 2.1 mm) with 1.7 μm particle size (Thermo Fisher Scientific, Fair Lawn, NJ, USA) was used for the chromatographic separation. The flow rate and composition of the mobile phases, as well as the gradient elution program, were previously described by Ivanov et al [ 23 ]. The mass detector was equipped with a heated electrospray ionization (HESI) source operated in the negative ionization mode.…”

Section: Methodsmentioning

confidence: 99%

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Chemical and Biological Investigations of Allium scorodoprasum L. Flower Extracts

et al. 2022

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This study was designed to investigate the impact of different extraction solvent systems on the chemical composition and biological activities of Allium scorodoprasum L. (Amaryllidaceae)—the medicinal plant that was traditionally used as a remedy in the medieval period in the Balkans. Targeted chemical analysis of nine different extracts was performed by UHPLC(−)HESI–QqQ-MS/MS. Antimicrobial and antibiofilm activities of the extracts were investigated on sixteen clinical isolates of bacteria, yeasts and dermatomycetes, all isolated from infected human skin and corneal formations. Cytotoxicity and wound-healing properties were tested on human immortalized keratinocytes (HaCaT cell line). Antioxidant activity was assessed by six different assays, while beneficial potential against certain neurodegenerative diseases and type 2 diabetes was determined in selected enzyme inhibition assays coupled with molecular modeling. The results showed that the obtained extracts were rich in phenolic compounds, especially flavonoid glycosides such as rutin and kaempferol 3-O-glucoside. All of the extracts showed antimicrobial, wound-healing, antioxidant and anti-enzymatic properties. This study is the first of its kind, linking the medieval medicinal use of wild-growing flowers of A. scorodoprasum with contemporary in vitro scientific approaches.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Chemical and Biological Investigations of Allium scorodoprasum L. Flower Extracts

et al. 2022

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“…Therefore, regardless of the type of extract (aqueous, alcoholic, hydroalcoholic), the type of plant, in addition to the type of bacteria, plays a role in influencing and inhibiting the growth of bacteria. Ivanov et al investigated the effect of different solvents for extracting Salvia nemorosa and introduced it as a natural bioactive therapeutic agent with antioxidant, antidiabetic and antimicrobial properties (29).…”

Section: Discussionmentioning

confidence: 99%

“…Aqueous Hydroalcoholic as a natural bioactive therapeutic agent with antioxidant, antidiabetic and antimicrobial properties [29].…”

Section: Methanolicmentioning

confidence: 99%

In Vitro Comparison of the Effects of Ailanthus altissima and Salvia Nemorosa Extracts on Pseudomonas aeruginosa, Staphylococcus aureus, and Proteus vulgaris

Farazandeh

Taghavizad²,

Moghaddam³

2022

CMJA

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Objective Some plants have antiseptic properties with no harm to humans or animals. In this study, we aim to assess the effects of Ailanthus altissima and Salvia nemorosa extracts on Pseudomonas aeruginosa, Staphylococcus aureus, and Proteus vulgaris in vitro. Methods Ailanthus altissima leaves and flowered branch of Salvia nemorosa were collected and dried in shade and powdered. Their aqueous, hydroalcoholic and methanolic extracts were prepared separately from the plants by Maceration method at four concentrations of 20, 30, 40, 50 mg/mL which were used in Mueller-Hinton Agar culture medium by the well diffusion method. Saponin was extracted was using 20% ethanol. The statistical results were analyzed in GraphPad Prism v.7 software. Results The aqueous extract of Salvia nemorosa was more effective on Pseudomonas aeruginosa (mean non-growth halo diameter = 26±1 mm). The diameter of the non-growth halo with Ailanthus altissima methanolic extract was 17.5±0.5 mm in Pseudomonas aeruginosa and 16.5±0.5 mm in Staphylococcus aureus, and the effect was significant (P<0.0001). Only Ailanthus altissima hydroalcoholic extract had an effect on Proteus vulgaris. High saponin content of two plants increased their effectiveness. Conclusion Aqueous extract of Salvia nemorosa is recommended to inhibit the growth and proliferation of Pseudomonas aeruginosa.

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Biochemistry of Secondary Metabolism in Plants

Rajčević

Bukvički

Stojković

et al. 2023

Natural Secondary Metabolites

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Bioactivities of Salvia nemorosa L. inflorescences are influenced by the extraction solvents

Cited by 10 publications

References 58 publications

Chemical and Biological Investigations of Allium scorodoprasum L. Flower Extracts

Chemical and Biological Investigations of Allium scorodoprasum L. Flower Extracts

In Vitro Comparison of the Effects of Ailanthus altissima and Salvia Nemorosa Extracts on Pseudomonas aeruginosa, Staphylococcus aureus, and Proteus vulgaris

Biochemistry of Secondary Metabolism in Plants

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