Bioactivities of polyphenolics from the roots of Bauhinia racemosa

Abstract

Various extracts of Bauhinia racemosa Lamk. (roots) and the isolated polyphenolics, viz. 1,7,8,12b-tetrahydro-2,2,4-trimethyl-10-methoxy-2H-benzo [6,7] cyclohepta[1,2,3-de][1]benzopyran-5,9-diol (racemosol) (1), 1,7,8,12b-tetrahydro-2,2,4-trimethyl-2H-benzo[6,7]cyclohepta[1,2,3-de][1]benzopyran-5,10,11-triol (2), and 1,7,8,12b-tetrahydro-2,2,4-trimethyl-2H-benzo[6,7] cyclohepta [1,2,3-de][1]benzopyran-5,9,10-triol (de-O-methyl racemosol) (3) were screened for antibacterial, antifungal, and antiviral activities. The isolated compounds exhibited profound antibacterial and antifungal activities while methanol extract exhibited potential efficacy against Herpes simplex virus.

New Cytotoxic Bibenzyl and Other Constituents from Bauhinia ungulata L. (Fabaceae)

“…Three known compounds (3 -5) were obtained from the AcOEt-soluble fraction of the EtOH extract of B. ungulata stem wood. The structures of known compounds (2 -14) were identified as 2 0 -hydroxy-3, 5-dimethoxybibenzyl (2), [24] liquiritigenin (3), [25] guibourtinidol (4), [26] fisetinidol (5), [27] taraxerol (6), [28] betulinic acid (7), [29] taraxerone (8), [28] glutinol (9), [30] a mixture of sitosterol (10) and stigmasterol (11), [31] pacharin (12), [21] [32] naringenin (13) [33] and eriodictyol (14) [34] on basis of spectral data, involving mainly 1D and 2D 1 H-and 13 C-NMR spectra and comparison with literature values (Fig. 1).…”

“…Many species of the Bauhinia genus have been widely used in folk medicine for treatment of diabetes . Plants from this pantropical genus have been shown to possess various biological activities such as analgesic, antipyretic, anti‐inflammatory, antimalarial, antimicrobial, antioxidant, and cytotoxic . Several classes of compounds have been isolated from Bauhinia species, including bibenzyls, steroids, triterpenoids oxepin derivatives, alkaloids, cyanoglucosides, and especially flavonoids …”

A new pentacyclic phenol and other constituents from the root bark of Bauhinia racemosa Lamk.

“…The antibacterial, antiviral and antifungal activities of root extract and isolated polyphenolics have also been reported (Jain et al 2008). However, there nothing is reported about the chemical constituents of the root bark.…”

“…The bark and leaves of this plant are reported to be medicinally important in traditional system of medicine and are used extensively for the treatment of inflammation, headache, fever, tumours, skin infection, blood diseases, dysentery and diarrhoea (Kirtikar & Basu 1975;Chopra et al 2006). Several chemical constituents from various parts of B. racemosa have been identified mainly as flavonols, coumarins, triterpenoids, stilbenes, polyphenols, steroids and tannins (Prakash & Khosla 1976;Balasooriya et al 1982;Anjaneyulu et al 1984Anjaneyulu et al , 1986Prabhakar et al 1994;El-Hossary et al 2000;Jain et al 2002Jain et al , 2008. Dried entire plant showed antimicrobial activity (Ali et al 1999).…”

“…Previous studies on the roots reported the isolation of de-O-methyl racemosol, 3-hydroxy- de-O-methyl racemosol, racemosol and 1,7,8,12b-tetrahydro-2,2,4-trimethyl-2H-benzo[6,7] cyclohepta [1,2,3-de][1]benzopyran-5,10,11 triol (Prabhakar et al 1994;Jain et al 2002Jain et al , 2008. The antibacterial, antiviral and antifungal activities of root extract and isolated polyphenolics have also been reported (Jain et al 2008).…”