Bioactivities of major constituents isolated from Angelica sinensis (Danggui)

Chao, Wen-Wan; Lin, Bi‐Fong

doi:10.1186/1749-8546-6-29

Cited by 126 publications

(83 citation statements)

References 71 publications

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“…The chromatogram obtained for ferulic acid determination, employing conditions adapted from the European Pharmacopoeia 6.0, is displayed in Figure 1(S) (Supplementary file). Both values are within the range of concentrations previously reported for these compounds (Chao & Lin, 2011;WHO, 2004).…”

Section: Phytochemical Analysis Of the As Extractsupporting

confidence: 69%

“…Diels (Apiaceae), a TCM drug also known as Danggui (or Dong Quai in English), has been used traditionally as a blood tonic to treat female sexual dysfunction such as menstrual disorders and menopausal symptoms (Chao & Lin, 2011;Low Dog, 2005). Modern research has highlighted several other pharmacological effects such as anti-inflammatory activity (Chao & Lin, 2011), immunomodulation (Choy et al, 1994), anti-tumoral activity (Chao & Lin, 2011), neuroprotection (Lin, 2011) and hepatoprotection (WHO, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Potential nephroprotective effects of the Chinese herbAngelica sinensisagainst cisplatin tubulotoxicity

Bunel

Antoine

Nortier

et al. 2014

Pharmaceutical Biology

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Context: Acute kidney injury (AKI) is often encountered in patients receiving cisplatin (CisPt), a chemotherapeutic drug that induces numerous toxic side effects. Techniques used to limit nephrotoxicity during CisPt treatment are not fully effective; about a third of patients experience AKI. New nephroprotective strategies, including pharmacological approaches, must be developed. Objective: The present study investigated the nephroprotective potential of Angelica sinensis (Oliv.) Diels (Apiaceae) root towards CisPt tubulotoxicity. Materials and methods: HK-2 cells were incubated with CisPt (10 mM) and/or with a methanolic extract of A. sinensis (AS). Nephroprotective capacity was evaluated by means of cellular viability (resazurin assay) and apoptosis (annexin-V/PI staining), oxidative stress generation (H 2 DCF-DA oxidation), Ki-67 index (immunofluorescence), cell cycle analysis (DNA staining), cell migration rate (scratch assay), extracellular matrix deposition (collagen determination), and b-catenin relocalization. Results: CisPt decreased cell viability [76% versus Ctrl], which was associated with an increased apoptosis. Simultaneous treatment with 50 mg/ml AS enhanced cell survival [84% versus Ctrl] and decreased the apoptosis rate. AS could not alleviate CisPt-induced oxidative stress; but doses of 5 and 50 mg/ml raised the Ki-67 index [135 and 244% versus Ctrl] and cell migration rates [1.2 and 1.3-fold versus Ctrl]. Finally, both doses of AS limited the amount of collagen deposition [121.6 and 119.6% for 5 and 50 mg/ml, respectively, versus 131.0% for CisPt-treated cells] and prevented the relocalization of b-catenin from the membrane to the nucleus. Conclusion: These results confirm the nephroprotective potential of A. sinensis and require further investigations aiming at identifying its active compounds.

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Section: Phytochemical Analysis Of the As Extractsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Potential nephroprotective effects of the Chinese herbAngelica sinensisagainst cisplatin tubulotoxicity

Bunel

Antoine

Nortier

et al. 2014

Pharmaceutical Biology

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“…In addition, it exhibits anticholinesterase and free radical scavenging activities and may exert anti-amnesic activity (Kwon et al, 2010). The antioxidant, anti-inflammatory and immunostimulatory ferulic acid (Chao & Lin, 2011) promotes degeneration of recombinant beta-amyloid peptide, as described by Picone et al (2009). Also caffeic acid has neuroprotective effects against A beta-induced toxicity by the inhibition of calcium influx and tau phosphorylation (Sul et al, 2009), and protects neuronal cells against oxidative stress induced cytotoxicity (Jeong et al, 2011).…”

Section: Chemical Analysismentioning

confidence: 99%

Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties

et al. 2012

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a b s t r a c tSalvia sclareoides is an aromatic herb native to Portugal, of which phenolic content (Folin-Ciocalteau method), chemical profile (HPLC/DAD), antioxidant activity (DPPH, b-carotene/linoleic acid assays), acute toxicity (MTT method, adapted for non-adherent cells), genotoxicity (short-term chromosomal aberration assay) and prion binding properties were evaluated in the acetone, water, ethanol, methanol and n-butanol extracts. The latter presented the highest phenolic content and antioxidant activity (DPPH assay), and was the single one with the flavonoids (+)-catechin, kaempferol O-glucoside and quercetin. Vanillic acid was the major component of all extracts but gallic, gentisic, caffeic, syringic, coumaric and ferulic acids were also found in some extracts. Only the n-butanol extract had components binding to the cellular form of human prion protein detected by NMR which showed specificity for two regions of the folded domain and for the unstructured N-terminal region. Extracts were not cytotoxic nor genotoxic, reinforcing the potential of S. sclareoides for nutraceutical purposes.

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“…It has also been widely known as a dietary supplement in Europe and America (Deng et al, 2006). In recent years, countless active components have been separated from the root of A. sinensis for their various pharmacological activities (Chao & Lin, 2011). Among them, polysaccharides, a major ingredient, have gained remarkable attention due to its exquisite pharmacological effects and low toxic (Liu et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the transport and absorption of Angelica sinensis polysaccharide through gastrointestinal tract both in vitro and in vivo

et al. 2017

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To investigate the absorption and delivery of ASP in gastrointestinal (GI) tract, cASP was successfully synthesized by chemically modifying with succinic anhydride and then conjugating with a near infrared fluorescent dye Cy5.5. Then, the capacity of oral absorption of cASP was evaluated. The results demonstrated that cASP had low toxicity and no disruption on the integrity of cell membrane. The endocytosis of cASP into the epithelial cells was time- and energy-dependent, which was mediated by macropinocytosis pathway and clathrin- and caveolae (or lipid raft)-related routes. Otherwise, the actin filaments played a relatively weak role at the same time. The transport study illustrated that cASP could penetrate through the epithelial monolayer and mainly mediated by the same routes as that in the endocytosis experiment. Moreover, both in vitro Ussing chamber and in vivo ligated intestinal loops models indicated that cASP could be diffused through the mucus barriers and be absorbed in the whole small intestine. Finally, near-infrared fluorescence imaging presented that cASP could be absorbed and circulated into the blood, then distributed into various organs after oral administration. In conclusion, ASP could be absorbed after oral administration through endocytosis process mainly mediated by macropinocytosis pathway and clathrin- and caveolae (or lipid raft)-related routes, then be absorbed and circulated into blood. This study presents a comprehensive understanding of oral delivery of cASP, which will provide theoretical basis for the clinical application of ASP.

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Bioactivities of major constituents isolated from Angelica sinensis (Danggui)

Cited by 126 publications

References 71 publications

Potential nephroprotective effects of the Chinese herbAngelica sinensisagainst cisplatin tubulotoxicity

Potential nephroprotective effects of the Chinese herbAngelica sinensisagainst cisplatin tubulotoxicity

Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties

Investigation of the transport and absorption of Angelica sinensis polysaccharide through gastrointestinal tract both in vitro and in vivo

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