Bioactivities of Chalcones

Abstract

This review outlines the different bioactivities of a variety of chalcones. The cytotoxic, anticancer, chemopreventative and mutagenic properties of a number of chalcones are described followed by an account of various of these unsaturated ketones as antimicrobial agents. The antiviral, antiprotozoal and insecticidal activities of a variety of chalcones are reviewed as well as the enzyme-inhibitory properties and miscellaneous activities of some of these molecules.

Chalcones suppress fatty acid-induced lipid accumulation through a LKB1/AMPK signaling pathway in HepG2 cells

“…Several synthetic chalcones have also shown themselves biologically active. 21,22 4-Hydroxyderricin (4HD) and xanthoangelol (XAG) are two chalcones from Angelica keiskei (Ashitaba), a Japanese herb that is used as a traditional medicine. The chalcones in this herb were reported to exert various biological effects against tumors, 23,24 inammation, 25 and diabetes.…”

In vitro and in vivo synergistic interaction of substituted chalcone derivatives with norfloxacin against methicillin resistant Staphylococcus aureus

“…The solid so obtained was ltered, column chromatographed and recrystallized from ethanol to afford pure 1-4. 13 13 , H-5 00 , H-6 00 ), 7.53 (1H, d, J ¼ 15.6 Hz, H-3), 7.61 (1H, d, J ¼ 2.7 Hz, H-2 0 ), 7.92 (1H, dd, J ¼ 8.4, 2.1 Hz, H-7 0 ), 8.01 (1H, dd, J ¼ 6.9, 2.7 Hz, H-4 00 ), 8.12 (1H, dd, J ¼ 7.2, 2.4 Hz, H-8 00 ), 8.62 (1H, s, H-2 00 ), 13.05 (1H, brs, NH); 13 Synthesis of chalcones (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). To a solution of respective acetophenone B (3-acetylindole for 6-11) (1 mmol) and appropriate aldehyde A (1 mmol) in methanol (20 mL) was added SOCl 2 (2 mL) and stirred the reaction mixture for 2 h. The contents of reaction mixture were poured into ice-cold water.…”

“…Chalcones have received a great deal of attention due to their relatively simple structures and wide variety of pharmacological activities. Both natural and synthetic chalcones exhibit a wide variety of activities like antimicrobial, 6,7 antimalarial 8 anti-inammatory, 9 anti-cancer 10 antioxidant 11 and many more. These activities are largely being attributed due to the unsaturated ketone moiety.…”

An efficient green chemistry protocol for the synthesis of novel spiropyrrolizidine compounds

“…Chalcones themselves have been reported to possess many useful properties, including anti-inammatory, antimicrobial, antifungal, antioxidant, cytotoxic, antitumor and anticancer activities. 22,23 So, inclusion of the chalcone moiety in the title compounds has been expected to enhance their biological activities. To the best of our knowledge, there are no reports of using chalcones for the above dipolar cycloaddition reactions.…”