Bioactivities of astaxanthin from natural sources, augmenting its biomedical potential: A review

Aneesh, Peruvazhipurath Appu; Ajeeshkumar, K.K.; Lekshmi, R.G.K.; Anandan, R.; Ravishankar, C.N.; Mathew, Suseela

doi:10.1016/j.tifs.2022.05.004

Cited by 46 publications

(39 citation statements)

References 92 publications

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“…The membrane permeability of free astaxanthin seems to be significantly affected by its low aqueous solubility and crystalline structure formation at body temperature. In general, naturally obtained or chemically synthesized astaxanthin esters provide an alternative to the use of astaxanthin in humans [ 105 ]. They are often more orally bioavailable than astaxanthin in lipid-based formulations and have better thermal stability [ 106 ].…”

Section: Antimelanoma Potential Of Carotenoids From Microalgaementioning

confidence: 99%

Carotenoids from Marine Microalgae as Antimelanoma Agents

et al. 2022

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Melanoma cells are highly invasive and metastatic tumor cells and commonly express molecular alterations that contribute to multidrug resistance (e.g., BRAFV600E mutation). Conventional treatment is not effective in a long term, requiring an exhaustive search for new alternatives. Recently, carotenoids from microalgae have been investigated as adjuvant in antimelanoma therapy due to their safety and acceptable clinical tolerability. Many of them are currently used as food supplements. In this review, we have compiled several studies that show microalgal carotenoids inhibit cell proliferation, cell migration and invasion, as well as induced cell cycle arrest and apoptosis in various melanoma cell lines. MAPK and NF-ĸB pathway, MMP and apoptotic factors are frequently affected after exposure to microalgal carotenoids. Fucoxanthin, astaxanthin and zeaxanthin are the main carotenoids investigated, in both in vitro and in vivo experimental models. Preclinical data indicate these compounds exhibit direct antimelanoma effect but are also capable of restoring melanoma cells sensitivity to conventional chemotherapy (e.g., vemurafenib and dacarbazine).

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Section: Antimelanoma Potential Of Carotenoids From Microalgaementioning

confidence: 99%

Carotenoids from Marine Microalgae as Antimelanoma Agents

et al. 2022

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“…Furthermore, astaxanthin may effectively protect cells against oxidative substances 7 and free radicals as because of its structural makeup. As a result of these features, astaxanthin is now used to prevent and cure a variety of pathological illnesses 8 …”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of astaxanthin‐loaded 2‐hydroxypropyl‐beta‐cyclodextrin and Soluplus® nanoparticles based on electrospray technology

et al. 2023

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BACKGROUND Astaxanthin is a type of food‐derived active ingredient with antioxidant, antidiabetic and non‐toxicity functions, but its poor solubility and low bioavailability hinder further application in food industry. In the present study, through inclusion technologies, micellar solubilization and electrospray techniques, we prepared astaxanthin nanoparticles before optimizing the formulation to regulate the physical and chemical properties of micelles. We accomplished the preparation of astaxanthin nanoparticle delivery system based on single needle electrospray technology through use of 2‐hydroxypropyl‐β‐cyclodextrin and Soluplus® to improveme the release behavior of the nanocarrier. RESULTS Through this experiment, we successfully prepared astaxanthin nanoparticles with a particle size of approximately 80 nm, which was further verified with scanning electron microscopy and transmission electron microscopy. Furthermore, the encapsulation of astaxanthin molecules into the carrier nanoparticles was verified via the results of attenuated total reflectance intensity and X‐ray powder diffraction techniques. The in vitro release behavior of astaxanthin nanoparticles was different in media that contained 0.5% Tween 80 (pH 1.2, 4.5 and 6.8) buffer solution and distilled water. Also, we carried out a pharmacokinetic study of astaxanthin nanoparticles, in which it was observed that astaxanthin nanoparticle showed an effect of immediate release and significant improved bioavailability. CONCLUSION 2‐hydroxypropyl‐β‐cyclodextrin and Soluplus® were used in the present study as a hydrophilic nanocarrier that could provide a simple way of encapsulating natural function food with repsect to improving the solubility and bioavailability of poorly water‐soluble ingredients. © 2023 Society of Chemical Industry.

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“…The most important biological activity of astaxanthin is its antioxidant activity. In addition, natural astaxanthin has been recognized by the United States Food and Drug Administration (USFDA) as generally recognized as safe (GRAS) [ 12 ]. Due to its strong antioxidant activity and deep red color, astaxanthin is considered a promising antioxidant and colorant [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Astaxanthin Extract from Shrimp (Trachypenaeus curvirostris) By-Products Improves Quality of Ready-to-Cook Shrimp Surimi Products during Frozen Storage at −18 °C

Zhu

Dai

et al. 2022

Foods

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The effects of astaxanthin extract (AE) from shrimp by-products on the quality and sensory properties of ready-to-cook shrimp surimi products (RC-SSP) during frozen storage at −18 °C were investigated. Changes in 2-thiobarbituric acid reactive substances (TBARS) value, sulfhydryl groups, carbonyls, salt-soluble protein content, textural properties, color, and sensory quality over specific storage days were evaluated. The AE from shrimp by-products contained 4.49 μg/g tocopherol and 23.23 μg/g astaxanthin. The shrimp surimi products supplemented with 30 g/kg AE had higher redness values and greater overall acceptability and texture properties after cooking (p < 0.05). AE showed higher oxidative stability in RC-SSP than the control, as evidenced by lower TBARS and carbonyl content, and higher sulfhydryl and salt-soluble protein content. AE from shrimp by-products had positive effects on the antioxidant activity and color difference of RC-SSP, and could be used as a potential multifunctional additive for the development of shrimp surimi products.

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Bioactivities of astaxanthin from natural sources, augmenting its biomedical potential: A review

Cited by 46 publications

References 92 publications

Carotenoids from Marine Microalgae as Antimelanoma Agents

Carotenoids from Marine Microalgae as Antimelanoma Agents

Preparation and evaluation of astaxanthin‐loaded 2‐hydroxypropyl‐beta‐cyclodextrin and Soluplus® nanoparticles based on electrospray technology

Astaxanthin Extract from Shrimp (Trachypenaeus curvirostris) By-Products Improves Quality of Ready-to-Cook Shrimp Surimi Products during Frozen Storage at −18 °C

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