Bioactivities and ethnopharmacology of Sesamum indicum L seed oil

Alves, E.; Wilairatana, Polrat; Cruz, Maria João; Campos, Laize Aparecida Nunes Lopes; Silva, Metton Ribeiro Lopes e; Alves, Dejane Santos; Araújo, Isaac Moura; Santos, Francisco Antônio Vieira dos; Farias, Pablo Antonio Maia de; Vasconcelos, Eliane Maria Gonçalves Moreira de; Siyadatpanah, Abolghasem; Coutinho, Henrique Douglas Melo; Figueredo, Fernando Gomes

doi:10.1016/j.lwt.2023.115120

Cited by 1 publication

(2 citation statements)

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“… 40 SO is one of the well‐known herbal remedies traditionally used to treat various conditions, including musculoskeletal pain and stiffness, inflammation, bruising, wound, and injury. 18 , 22 , 41 Recent RCTs have investigated the potential impact of administrating SO on treating the pain of limb trauma; however, their findings are controversial. Accordingly, we synthesised these conflicting findings qualitatively and quantitatively to elicit a reliable conclusion regarding the potential effect of topical SO for alleviating limb trauma pain.…”

Section: Discussionmentioning

confidence: 99%

“… 21 Likewise, the medicinal properties of SO have been acknowledged and incorporated into the traditional medical systems of China and India, given its benefits for treating pain, inflammation, wound, and haemorrhoid. 22 , 23 Meanwhile, SO has been used for massage therapy in Ayurvedic medicine, and surprisingly, it is considered a sacred oil in the Hindu religion. 24…”

Section: Introductionmentioning

confidence: 99%

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Alleviating severity of limb trauma pain with coadministration of topical sesame oil and standard treatments: A GRADE‐assessed systematic review and meta‐analysis of randomised controlled trials

Razani,

Nasiri,

Yarahmadi

et al. 2024

International Wound Journal

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Recent randomised controlled trials (RCTs) have investigated the analgesic activity of sesame oil among patients with limb trauma; nevertheless, their findings are inconsistent. Hence, this review aimed to clarify the impact of topical administration of sesame oil on acute pain of adult outpatients with minor limb trauma. The online databases (e.g., Scopus, PubMed, Web of Science) were searched up to 31 January 2024. The RCTs were included if they compared the effect of applying standard treatments plus topical sesame oil to administering standard treatments alone or with a placebo/sham treatment. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) and the Cochrane Collaboration's risk of bias tool were applied to address the evidence quality and the study's methodological rigour, respectively. Four RCTs had the inclusion criteria, and their findings were pooled in a meta‐analysis employing a random‐effects approach. According to the pooled analysis, the reduction in mean change of the pain score from baseline to the second/third intervention day was significantly higher in favour of clients who received standard care plus daily massage of the trauma site with sesame oil compared to those who received a control condition (weighted mean difference: −1.10; 95% confidence interval [−1.62, −0.57]; p < 0.001). However, the evidence quality was moderate, and only two studies had good methodological rigour. Hence, more high‐quality studies are needed to make a solid evidence‐based conclusion about the favourable consequence of topical sesame oil on alleviating acute traumatic limb pain.

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