Bioactives from microalgal dinoflagellates

Gallardo, Juan José; Sánchez-Mirón, A.; Camacho, F. Garcı́a; López-Rosales, L.; Chisti, Yusuf; Grima, E. Molina

doi:10.1016/j.biotechadv.2012.07.005

Cited by 89 publications

(68 citation statements)

References 188 publications

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“…Although many compounds isolated from dinoflagellates have shown bioactivities of interest (Camacho et al, 2007;Blunt et al, 2011), only a few have led to commercial products (Gallardo-Rodríguez et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Despite the many interesting bioactive compounds isolated from dinoflagellates (Konishi et al, 2004;Camacho et al, 2007;Blunt et al, 2011), only a few have led to commercial products. This is partly due to the limited amount of dinoflagellate toxin that can be amassed for detailed clinical evaluation (Gallardo-Rodríguez et al, 2012). Nevertheless, recent patents and patent applications related to dinoflagellate toxins have been published (Selander & Pavia, 2008;Paul, 2011).…”

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confidence: 99%

“…Dinoflagellates are a large group of flagellate protists, belonging mostly to marine phytoplankton, some of which are known to form harmful algal blooms that are an important source of marine biotoxins (Tomas, 1997;Gallardo-Rodríguez et al, 2012). Bioactive compounds from dinoflagellates have received increased attention because of their impact on the safety of seafood and their potential uses in biomedical, toxicological and pharmacological research.…”

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confidence: 99%

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The inhibitory effect of a non-yessotoxin-producing dinoflagellate, Lingulodinium polyedrum (Stein) Dodge, towards Vibrio vulnificus and Staphylococcus aureus

Quijano-Scheggia

Barajas-Gonzalez

Lim

et al. 2016

RBT

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Abstract:The increased bacterial resistance to antibiotics has caused global concern, prompting the search for new compounds. Because of their abundance and diversity, marine phytoplankton are an important potential source of such compounds. Research on dinoflagellates has led to the discovery of inhibitors of bacterial growth. The marine dinoflagellate Lingulodinium polyedrum blooms in different regions of the world, including Mexico, and is also known to regulate the growth of other species in coastal waters. Here, we investigated the taxonomy of this dinoflagellate and characterized the ability of its extracts to inhibit the growth of two bacteria of medical importance (Vibrio vulnificus and Staphylococcus aureus). Taxonomic characterization was performed by PCR and gene amplification of ITS, and confirmed that the species isolated off the Pacific coast of Mexico was L. polyedrum. To prove the inhibitory effect of L. polyedrum extracts, cultures were harvested by centrifugation. Pellets from three cellular abundances were extracted with water, methanol, hexane and chloroform. The experiments on V. vulnificus showed a high growth inhibition for the four extracts, ranging from 77 to 98 %. Surprisingly, the growth inhibition was lower when the extracts originated from a higher L. polyedrum cell abundance, ranging from 0 to 34 %. For S. aureus, the growth inhibition was also high, but not statistically different for all extracts and cell abundances, ranging from 62 to 99 %. This study obtained promising results for future pharmacological applications. Our Mexican strain of L. polyedrum did not produce any detectable yessotoxins. Rev. Biol. Trop. 64 (2): 805-816. Epub 2016 June 01.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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The inhibitory effect of a non-yessotoxin-producing dinoflagellate, Lingulodinium polyedrum (Stein) Dodge, towards Vibrio vulnificus and Staphylococcus aureus

Quijano-Scheggia

Barajas-Gonzalez

Lim

et al. 2016

RBT

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“…Some dinotoxins are considered to exhibit interesting bioactivities (Camacho et al, 2007;Gallardo-Rodríguez et al, 2012), and several recent patents have been presented in relation to their application. They can also be considered for the assessment of seafood safety, and for the detection and quantification of HAB species.…”

Section: 32mentioning

confidence: 99%

Gene Mining for Environmental Studies and Applications: Examples from Marine Organisms

Dittami

Tonon

2014

Outstanding Marine Molecules

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In this chapter, some of the most common techniques used to generate genomic and transcriptomic data, that is, sequence and gene expression information, are reviewed. Examples are then given as to how these data can be exploited to understand the physiology of marine organisms. Emphasis is placed on studies conducted to gain insights on the response of corals to climate change (temperature and acidification), and on toxin production by dinoflagellates (dinotoxins). Finally, attention is focused on molecular biomonitoring techniques, and how sequence information can be used to assess the quality of food and the environment for the benefit of humans. The integration of genomic and transcriptomic data with other levels of analysis will lay the ground for a better understanding and exploitation of the potential of marine systems.

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“…Historically, plants have delivered an abundance of useful bioactive natural products, but their marine relatives consist solely of the Chlorophyta (green algae) of which there are an estimated 13,000 species [7]; however, this is small compared to the~375,000 species of terrestrial plants meaning that marine-plant-based discovery may be limited. Nevertheless, there are other oceanic organisms deserving of greater attention, such as true fungi, dinoflagellates, cyanobacteria and diatoms, given the metabolic capabilities of their terrestrial and freshwater relatives to produce chemically diverse natural products and the exquisite biodiversity of these groups in marine systems [8][9][10]. Many of these organisms contain the enzymatic machinery required to produce interesting and novel bioactive products, including polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) pathways.…”

Section: Organisms Of Interestmentioning

confidence: 99%

How might we increase success in marine-based drug discovery?

Desbois

2014

Expert Opinion on Drug Discovery

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Bioactives from microalgal dinoflagellates

Cited by 89 publications

References 188 publications

The inhibitory effect of a non-yessotoxin-producing dinoflagellate, Lingulodinium polyedrum (Stein) Dodge, towards Vibrio vulnificus and Staphylococcus aureus

The inhibitory effect of a non-yessotoxin-producing dinoflagellate, Lingulodinium polyedrum (Stein) Dodge, towards Vibrio vulnificus and Staphylococcus aureus

Gene Mining for Environmental Studies and Applications: Examples from Marine Organisms

How might we increase success in marine-based drug discovery?

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