Bioactive Zinc(II) complex incorporated PCL/gelatin electrospun nanofiber enhanced bone tissue regeneration

Preeth, Desingh Raj; Sekaran, Saravanan; Shairam, Manickaraj; Selvakumar, N.; Raja, Iruthayapandi Selestin; Dhanasekaran, Anuradha; Vimalraj, Selvaraj

doi:10.1016/j.ejps.2021.105768

Cited by 54 publications

(44 citation statements)

References 52 publications

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“…The chick embryo chorioallantoic membrane (CAM) assay demonstrated that the angiogenic parameters were increased by the (Zn + Q(PHt)) complex. Meanwhile, the (Zn + Q(PHt)) complex showed significant activity and thereby this complex was further examined for the bone tissue activity by incorporating the complex into a nanofiber through electrospinning method [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…The UV-Visible absorption and IR spectra prove the B-ring chelation of the flavonoid quercetin to Zn(II) rather C-ring chelation. At the molecular level, Runx2, mRNA and protein, ALP and type 1 collagen mRNAs, and osteoblast-specific microRNA, pre-mir-15b were examined using real-time RT-PCR and Western blot assay [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

“…To achieve these goals, several biomaterials have been employed, including autologous bone, bone substitutes (allografts, xenografts, and alloplasts), blood [ 7 ] and active barrier membranes [ 8 ]. In this line, it has been recently shown from a clinical standpoint that quercetin-zinc complex incorporated into polycaprolactone/gelatin nanofiber can promote bone regeneration [ 9 ]. Anorganic bovine-derived hydroxyapatite/cell-binding peptide grafts have been proposed to treat intrabony defects in conventional periodontal surgery [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have proposed to include some metallic materials, such as Fe- and Mg-based alloys, and more recently Zn-alloys [ 14 ] to biodegradable matrices. Zn is an essential mineral that is vital for routine skeletal growth [ 9 ]. Zn can be found in the human body, being present in all tissues and more than 200 types of enzymes [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Incorporation of Zn into a membrane for GBR favors the proliferation of osteoblasts [ 25 ], triggers bone neoformation and inhibits bacterial biofilm formation [ 28 , 29 , 30 ]. In addition, animal studies using Zn-doped nanostructured membranes show faster bone healing and regeneration [ 9 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Toledano

Vallecillo-Rivas

Osório³

et al. 2021

Polymers

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Barrier membranes are employed in guided bone regeneration (GBR) to facilitate bone in-growth. A bioactive and biomimetic Zn-doped membrane with the ability to participate in bone healing and regeneration is necessary. The aim of the present study is to state the effect of doping the membranes for GBR with zinc compounds in the improvement of bone regeneration. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. A narrative exploratory review was undertaken, focusing on the antibacterial effects, physicochemical and biological properties of Zn-loaded membranes. Bioactivity, bone formation and cytotoxicity were analyzed. Microstructure and mechanical properties of these membranes were also determined. Zn-doped membranes have inhibited in vivo and in vitro bacterial colonization. Zn-alloy and Zn-doped membranes attained good biocompatibility and were found to be non-toxic to cells. The Zn-doped matrices showed feasible mechanical properties, such as flexibility, strength, complex modulus and tan delta. Zn incorporation in polymeric membranes provided the highest regenerative efficiency for bone healing in experimental animals, potentiating osteogenesis, angiogenesis, biological activity and a balanced remodeling. Zn-loaded membranes doped with SiO2 nanoparticles have performed as bioactive modulators provoking an M2 macrophage increase and are a potential biomaterial for promoting bone repair. Zn-doped membranes have promoted pro-healing phenotypes.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Toledano

Vallecillo-Rivas

Osório³

et al. 2021

Polymers

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An Overview of the Electrospinning of Polymeric Nanofibers for Biomedical Applications Related to Drug Delivery

CeCe,

Jining,

Islam

et al. 2023

Adv Eng Mater

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Electrospinning is a prominent technique for micro/nanofiber production and has received significant attention in the 21st century. It enables the production of ultrafine fibers using a variety of polymers, including synthetic, natural, and hybrid materials. Electrospun nanofibers (NFs) possess unique properties such as a high surface‐to‐volume ratio, tunable pore structures, and customizable composition, making them highly desirable in various fields such as biomedical science, textiles, sensors, filters, energy, and packaging. Here, particular attention will be given to the application of NFs in biomedical fields. The use of NFs for the delivery of drugs, growth factors, proteins, nanoparticles (NPs), etc., holds significant promise in the field of biomedical science. To combine these compounds with NFs, various electrospinning techniques have been developed with outstanding improvements, and based on the requirements of the application type, different electrospinning processes are favored. In this review, the most common drug loading methods into NFs, generally used synthetic/natural polymers for NF production, and their application in drug delivery systems, tissue engineering, and wound dressing will be mentioned. Finally, challenges and future perspectives for above mentioned biomedical applications were discussed.This article is protected by copyright. All rights reserved.

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Angiogenic and osteogenic effects of flavonoids in bone regeneration

Shanmugavadivu

Balagangadharan

Selvamurugan

2022

Biotech & Bioengineering

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Bone is a highly vascularized tissue that relies on a close spatial and temporal interaction between blood vessels and bone cells. As a result, angiogenesis is critical for bone formation and healing. The vascular system supports bone regeneration by delivering oxygen, nutrients, and growth factors, as well as facilitating efficient cell-cell contact.Most clinical applications of engineered bone grafts are hampered by insufficient vascularization after implantation. Over the last decade, a number of flavonoids have been reported to have osteogenic-angiogenic potential in bone regeneration because of their excellent bioactivity, low cost, availability, and minimal in vivo toxicity. During new bone formation, the osteoinductive nature of certain flavonoids is involved in regulating multiple signaling pathways contributing toward the osteogenic-angiogenic coupling. This review briefly outlines the osteogenic-angiogenic potential of those flavonoids and the mechanisms of their action in promoting bone regeneration. However, further studies are needed to investigate their delivery strategies and establish their clinical efficacy.

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Bioactive Zinc(II) complex incorporated PCL/gelatin electrospun nanofiber enhanced bone tissue regeneration

Cited by 54 publications

References 52 publications

Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

An Overview of the Electrospinning of Polymeric Nanofibers for Biomedical Applications Related to Drug Delivery

Angiogenic and osteogenic effects of flavonoids in bone regeneration

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