Bioactive Wound Dressings for the Management of Chronic Wounds

Georgescu, Mara; Chifiriuc, Mariana Carmen; Măruţescu, Luminiţa; Gheorghe, Irina; Lazăr, Veronica; Bolocan, Alexandra; Berteșteanu, Șerban

doi:10.2174/1385272820666160510171040

Cited by 30 publications

(18 citation statements)

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“…The introduction of bioactive factors in the search of more effective recovery has been widely studied [76,194,229,[239][240][241][242][243], as bioactive factors have significant biological activity in vivo in wound repair and regeneration. This section will focus on the use of GFs and nucleic acids, but for the sake of simplicity, antibiotics and bactericides will not be covered [244].…”

Section: Chemical and Biochemical Signallingmentioning

confidence: 99%

Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms

Castaño

Pérez‐Amodio

Nieva

et al. 2018

Advanced Drug Delivery Reviews

151

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Skin wound healing aims to repair and restore tissue through a multistage process that involves different cells and signalling molecules that regulate the cellular response and the dynamic remodelling of the extracellular matrix. Nowadays, several therapies that combine biomolecule signals (growth factors and cytokines) and cells are being proposed. However, a lack of reliable evidence of their efficacy, together with associated issues such as high costs, a lack of standardization, no scalable processes, and storage and regulatory issues, are hampering their application. In situ tissue regeneration appears to be a feasible strategy that uses the body's own capacity for regeneration by mobilizing host endogenous stem cells or tissue-specific progenitor cells to the wound site to promote repair and regeneration. The aim is to engineer instructive systems to regulate the spatio-temporal delivery of proper signalling based on the biological mechanisms of the different events that occur in the host microenvironment. This review describes the current state of the different signal cues used in wound healing and skin regeneration, and their combination with biomaterial supports to create instructive microenvironments for wound healing.

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Section: Chemical and Biochemical Signallingmentioning

confidence: 99%

Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms

Castaño

Pérez‐Amodio

Nieva

et al. 2018

Advanced Drug Delivery Reviews

151

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“…The bioactive agents that can be transported by these wound dressings include antibiotics, antioxidants, growth factors, stem cells, vitamins, and plant extracts, etc. [ 37 ]. Examples of bioactive dressings include hydrogels, nanofibers, membranes, films, transdermal patches, foams, and wafers.…”

Section: Classification Of Wound Dressingsmentioning

confidence: 99%

Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds

et al. 2021

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The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.

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“…It can be capable to provide a support for the release of bioactive compounds such as antimicrobial agents (antibiotics, antiseptics, honey, plant extracts), insulin. 21 The main purpose of using antimicrobials is to prevent the infections especially in chronic wounds. Cutisorb is one of the commercially available antimicrobial dressings.…”

Section: Wound Dressingmentioning

confidence: 99%

“…These wound dressings have integral healing activity. It can be capable to provide a support for the release of bioactive compounds such as antimicrobial agents (antibiotics, antiseptics, honey, plant extracts), insulin . The main purpose of using antimicrobials is to prevent the infections especially in chronic wounds.…”

Section: Woundmentioning

confidence: 99%

Recent advances on herb‐derived constituents‐incorporated wound‐dressing materials: A review

Thomas

2019

Polymers for Advanced Techs

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Since ancient times, wound dressings have evolved with persistent and substantial changes. Several efforts have been made toward the development of new dressing materials, which can meet the demanding conditions for the treatment of skin wounds. Currently, many studies have been focused on the production and designing of herb‐incorporated wound dressings. Herb‐derived constituents are more effective than conventional medicines because of their nontoxic nature and can be administered over long periods. Herbal medicines in wound healing provide a suitable environment for aiding the natural course of healing. This review mainly focuses on the diverse approaches that have been developed to produce a wound dressing material, which can deliver herb‐derived bioactive constituents in a controlled manner. This review also discusses the common wound‐dressing materials available, basic principles of wound healing, and wound‐healing agents from medicinal plants.

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Bioactive Wound Dressings for the Management of Chronic Wounds

Cited by 30 publications

References 0 publications

Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms

Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms

Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds

Recent advances on herb‐derived constituents‐incorporated wound‐dressing materials: A review

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