Bioactive substances of cyanobacteria and microalgae: Sources, metabolism, and anticancer mechanism insights

Bouyahya, Abdelhakim; Bakrim, Saad; Chamkhi, Imane; Taha, Douae; El Omari, Nasreddine; El Mneyiy, Naoual; El Hachlafi, Naoufal; El-Shazly, Mohamed; Khalid, Asaad; Abdalla, Ashraf N.; Goh, Khang Wen; Ming, Long Chiau; Goh, Bey Hing; Aanniz, Tarik

doi:10.1016/j.biopha.2023.115989

Cited by 12 publications

(1 citation statement)

References 246 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cyanobacteria are single-celled prokaryotes capable of oxygen-producing photosynthesis, which are mainly used in fields such as fertilizers and fuels ( Arias et al, 2021 ). Recent studies have found that Cyanobacteria contains a variety of bioactive components that can induce autophagy and apoptosis, regulate epigenetic modifications, and exert antitumor effects ( Bouyahya et al, 2024 ). Xu et al (2019) found that Cyanobacteria were associated with neuropsychological behavior induced by long-term alcohol exposure, and the mechanism may be related to the secretion of brain-derived neurotrophic factor.…”

Section: Discussionmentioning

confidence: 99%

Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota

Yu,

Guo,

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

BackgroundAnorexia nervosa (AN) and bulimia nervosa (BN) poses a significant challenge to global public health. Despite extensive research, conclusive evidence regarding the association between gut microbes and the risk of AN and BN remains elusive. Mendelian randomization (MR) methods offer a promising avenue for elucidating potential causal relationships.Materials and methodsGenome-wide association studies (GWAS) datasets of AN and BN were retrieved from the OpenGWAS database for analysis. Independent single nucleotide polymorphisms closely associated with 196 gut bacterial taxa from the MiBioGen consortium were identified as instrumental variables. MR analysis was conducted utilizing R software, with outlier exclusion performed using the MR-PRESSO method. Causal effect estimation was undertaken employing four methods, including Inverse variance weighted. Sensitivity analysis, heterogeneity analysis, horizontal multivariate analysis, and assessment of causal directionality were carried out to assess the robustness of the findings.ResultsA total of 196 bacterial taxa spanning six taxonomic levels were subjected to analysis. Nine taxa demonstrating potential causal relationships with AN were identified. Among these, five taxa, including Peptostreptococcaceae, were implicated as exerting a causal effect on AN risk, while four taxa, including Gammaproteobacteria, were associated with a reduced risk of AN. Similarly, nine taxa exhibiting potential causal relationships with BN were identified. Of these, six taxa, including Clostridiales, were identified as risk factors for increased BN risk, while three taxa, including Oxalobacteraceae, were deemed protective factors. Lachnospiraceae emerged as a common influence on both AN and BN, albeit with opposing effects. No evidence of heterogeneity or horizontal pleiotropy was detected for significant estimates.ConclusionThrough MR analysis, we revealed the potential causal role of 18 intestinal bacterial taxa in AN and BN, including Lachnospiraceae. It provides new insights into the mechanistic basis and intervention targets of gut microbiota-mediated AN and BN.

show abstract

Section: Discussionmentioning

confidence: 99%

Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota

Yu,

Guo,

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

Light‐Driven Green‐Fabricated Artificial Intelligence‐Enabled Micro/Nanorobots for Multimodal Phototherapeutic Management of Bladder Cancer

Hsiao,

Lin,

Liu

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Combination therapy based on precise phototherapies combined with immune modulation provides successful antitumor effects. In this study, a combination therapy is designed based on phototactic, photosynthetic, and phototherapeutic Chlamydomonas Reinhardtii (CHL)‐glycol chitosan (GCS)‐polypyrrole (PPy) nanoparticle (NP)‐enhanced immunity combined with the tumor microenvironment turnover of cytotoxic T cells and M1/M2 macrophages, which is based on photothermal GCS‐PPy NPs decorated onto the phototactic and photosynthetic CHL. Phototherapy based on CHL‐GCS‐PPy NPs alleviates hypoxia and modulates the tumor immune microenvironment, which induces tumor cell death. In particular, the precise antitumor immune response and potent immune memory induced by combining self‐navigated phototherapies significantly alleviate the progression of bladder cancer in C57BL/6 mice and effectively inhibit bladder tumor growth. Furthermore, they also potentially prevent tumor recurrence, which provides a promising therapeutic strategy for clinical tumor therapy.

show abstract

Applications, advancements, and challenges of cyanobacteria-based biofertilizers for sustainable agro and ecosystems in arid climates

Bibi,

Saadaoui,

Bibi

et al. 2024

Bioresource Technology Reports

View full text Add to dashboard Cite

Bioactive substances of cyanobacteria and microalgae: Sources, metabolism, and anticancer mechanism insights

Cited by 12 publications

References 246 publications

Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota

Anorexia nervosa and bulimia nervosa: a Mendelian randomization study of gut microbiota

Light‐Driven Green‐Fabricated Artificial Intelligence‐Enabled Micro/Nanorobots for Multimodal Phototherapeutic Management of Bladder Cancer

Applications, advancements, and challenges of cyanobacteria-based biofertilizers for sustainable agro and ecosystems in arid climates

Contact Info

Product

Resources

About