Bioactive substances inhibiting COX-2 and cancer cells isolated from the fibrous roots of <i>Alangium chinense</i> (Lour.) Harms

Xiao, Ting; Cheng, Xingyan; Huang, Jiaoyan; Guo, Zhenghong; Tao, Ling; Shen, Xiangchun

doi:10.1039/d2ra06931h

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…Similarly, Sharma and Janmeda (2017) isolated the 2‐(3,4‐dihydroxy‐5‐methoxy‐phenyl)‐3,5‐dihydroxy‐6,7‐dimethoxychromen‐4‐one from the hydro‐ethanolic extract of EN that reported to have anticarcinogenic activity. Furthermore, Alangium chinense compounds (1, 5, 12, and 21) demonstrated cytotoxicity against HepG2 cells, compounds 2 and 21 demonstrated cytotoxicity against Caco‐2 cells, and compound 20 demonstrated cytotoxicity against HeLa cells (Xiao et al, 2023).…”

Section: Resultsmentioning

confidence: 99%

Microscopic characterization, TLC fingerprinting and optimization of total lipid content from Euphorbia neriifolia (L.) using response surface methodology

Chaudhary,

Meena,

Janmeda

2023

Microscopy Res & Technique

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Euphorbia neriifolia (EN) is a medicinal plant used to treat a variety of ailments in traditional systems. Despite numerous studies on pharmacological activities, no information was available on the microscopic study of this plant. This is the first study that has been attempted to fill this need by performing the light and field emission scanning electron microscopy (FESEM) of leaf, stem, and latex. The powder microscopy of several organs (leaves, stem, and bark) and exudate (latex) of EN was carried out using safranine, fast green, phloroglucinol, and other standard solutions at different magnifications. The chemical fingerprinting of petroleum ether extract was accomplished by using thin layer chromatography. The optimization of total lipid content from the EN leaf under ultrasound‐assisted extraction (UAE) and soxhlet extraction (SE) procedure was determined using response surface methodology (RSM). The studied factors that affect the lipid content were: solvent ratio, extraction temperature, and extraction time. Several notable characteristics observed in the leaf of EN are amphistomatic leaves with anticlinical cell walls, anomocytic stomata, spongy mesophyll cells, elongated palisade cells, angular collenchyma, and U‐shaped vascular bundle. The plano‐convex midrib is covered by polygonal to oval‐shaped cuticles and contains anomocytic stomata. The circular petiole has no trichomes and contains laticifers, crystals, and idioblasts. The circular stem was observed with trichomes, hypodermis, collenchyma, parenchymatous cells, central pith, pentagonal stellar region, cambium, and 2–4 times more xylem that of phloem. All of the powdered plant parts and exudate under study contained trichomes, xylem vessels, wood fibers, cork cells, starch grains, calcium oxalate crystals, idioblasts, lignified cork, tannin content, stone cells, and oil globules. The blackish‐green colored petroleum ether extract with semi‐solid consistency showed the greatest percent (%) yield of 4% in the latex of EN. The thin layer chromatography (TLC) examination of petroleum ether extract of EN leaf produced a maximum 6 spots with Rf values of 0.16, 0.58, 0.62, 0.73, and 0.96 in the mobile phase of petroleum ether‐acetone (8:2). In terms of optimization, the dark green colored UAE extract with semi‐sticky consistency showed highest % yield of 4.5% whereas the yellowish green colored SE extract of sticky consistency showed the highest % yield of 4.9%. The findings showed that there were not many differences in the total lipid content between UAE (0.16%) and SE (0.11%). However, the best optimum condition for lipid content extraction analysis was obtained as follows: solvent ratio (PE:HE) 50:50, extraction temperature 50°C, extraction time 45 min for UAE, and solvent ratio (PE:HE) 60:40, extraction temperature 45°C, and extraction time of 24 h for SE. Hence, this study signifies the various noteworthy microscopic features along with the presence of different phytocompounds through TLC and best optimized condition for the extraction of lipids from different parts of EN. As no previous study has been reported, the outcomes obtained from the current study prove to be beneficial in the identification of species, quality control, and detection of any adulteration from the laboratory and commercial samples of EN.Research Highlights The percent yield was found to be maximum in latex extract (4%). The leaf pet ether extract was separated into 6 bands with different Rf values. The extracted compounds from Euphorbia neriifolia leaves were categorized into non‐polar heat tolerant. The highest total lipid yield (0.1119) was obtained at solvent ratios 60:40 of PE:HE (petroleum ether: petroleum hexane).

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Section: Resultsmentioning

confidence: 99%

Microscopic characterization, TLC fingerprinting and optimization of total lipid content from Euphorbia neriifolia (L.) using response surface methodology

Chaudhary,

Meena,

Janmeda

2023

Microscopy Res & Technique

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“…For example, a study by Li XJ et al, in 2021 suggested that Frankincense oil, derived from the Boswellia carterii plant, contains a compound with the potential to inhibit COX-2 expression in an animal model of hind paw inflammation [ 49 ]. Similarly, research involving the fibrous root of the Chinese plant Alangium chinense revealed sesquiterpenes with anti-inflammatory properties, outperforming standard drugs in terms of their effectiveness [ 50 ]. These findings suggest that natural compounds may hold the key to managing inflammation and AD.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology-based approach to elucidate the pharmacologic mechanisms of natural compounds from Dictyostelium discoideum for Alzheimer's disease treatment

Patil,

Dhariwal,

Mohammed

et al. 2024

Heliyon

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“…Harms. Recent studies have shown that monomeric compounds from Alangium chinese exhibit good inhibitory effects on HeLa cells [ 6 ]. The current research has placed significant emphasis on Alangium chinense , but insufficient with regards to AP.…”

Section: Introductionmentioning

confidence: 99%

Anti-cervical cancer mechanism of bioactive compounds from Alangium platanifolium based on the ‘compound-target-disease’ network

Zhang,

et al. 2023

Heliyon

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Bioactive substances inhibiting COX-2 and cancer cells isolated from the fibrous roots of Alangium chinense (Lour.) Harms

Abstract: Alangium chinense has been used as a traditional folk medicine for centuries to treat rheumatism, skin diseases, and diabetes by the people of Southeast Asia.

Cited by 5 publications

References 43 publications

Microscopic characterization, TLC fingerprinting and optimization of total lipid content from Euphorbia neriifolia (L.) using response surface methodology

Microscopic characterization, TLC fingerprinting and optimization of total lipid content from Euphorbia neriifolia (L.) using response surface methodology

Network pharmacology-based approach to elucidate the pharmacologic mechanisms of natural compounds from Dictyostelium discoideum for Alzheimer's disease treatment

Anti-cervical cancer mechanism of bioactive compounds from Alangium platanifolium based on the ‘compound-target-disease’ network

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