Bioactive SrO–SiO2 glass with well-ordered mesopores: Characterization, physiochemistry and biological properties

Wu, Chengtie; Fan, Wei; Gelinsky, Michael; Xiao, Yin; Simon, Paul; Schulze, Renate; Doert, Thomas; Luo, Yongxiang; Cuniberti, Gianaurelio

doi:10.1016/j.actbio.2010.12.018

Cited by 113 publications

(66 citation statements)

References 35 publications

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“…We have developed a series of MBG scaffolds with varying compositions for drug delivery and bone tissue engineering application. [98][99][100][101] The prepared scaffolds possess large pores with the size of 300-500 µm, and well-ordered mesopores with the pore size of 5 nm (Figure 3). The advantages of the MBG scaffolds prepared by polyurethane sponge template method include their highly interconnective pore structures and controllable pore size (porosity), while the disadvantage is the low mechanical strength of the material.…”

Section: Nanotechnology In Bone Regenerationmentioning

confidence: 99%

Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

Wu²,

Chen³

et al. 2013

IJN

Self Cite

153

111

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Nanotechnology is a vigorous research area and one of its important applications is in biomedical sciences. Among biomedical applications, targeted drug delivery is one of the most extensively studied subjects. Nanostructured particles and scaffolds have been widely studied for increasing treatment efficacy and specificity of present treatment approaches. Similarly, this technique has been used for treating bone diseases including bone regeneration. In this review, we have summarized and highlighted the recent advancement of nanostructured particles and scaffolds for the treatment of cancer bone metastasis, osteosarcoma, bone infections and inflammatory diseases, osteoarthritis, as well as for bone regeneration. Nanoparticles used to deliver deoxyribonucleic acid and ribonucleic acid molecules to specific bone sites for gene therapies are also included. The investigation of the implications of nanoparticles in bone diseases have just begun, and has already shown some promising potential. Further studies have to be conducted, aimed specifically at assessing targeted delivery and bioactive scaffolds to further improve their efficacy before they can be used clinically.

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Section: Nanotechnology In Bone Regenerationmentioning

confidence: 99%

Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

Wu²,

Chen³

et al. 2013

IJN

Self Cite

153

111

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“…In particular, boron release has been associated with cell growth inhibition for 12 concentrations greater then 2.5 mM and also causes cytotoxicity due to release of (BO3) 3-into the 13 medium 12,19,20 . Several cellular studies investigated the cytotoxicity of BGs and reported inhibition 14 of cell viability and proliferation for high doses of ions in culture 21,22 . For instance, Santocildes-15 Romero et al 23 have showed an increase of the cytotoxic effect of BGs dissolution by increasing 16 the amount of glass powders used and the level of strontium substitution added to the glass 17 for the treatment of osteoporosis 21 .…”

Section: Introductionmentioning

confidence: 99%

“…Several cellular studies investigated the cytotoxicity of BGs and reported inhibition 14 of cell viability and proliferation for high doses of ions in culture 21,22 . For instance, Santocildes-15 Romero et al 23 have showed an increase of the cytotoxic effect of BGs dissolution by increasing 16 the amount of glass powders used and the level of strontium substitution added to the glass 17 for the treatment of osteoporosis 21 . 24 Various studies have been reported concerning the use of heat treatments in order to induce 25 crystallisation in BGs to promote changes in their physico-chemical properties [27][28][29][30][31] .…”

Section: Introductionmentioning

confidence: 99%

Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives

Fernandes

Gentile

Moorehead

et al. 2016

Crystal Growth & Design

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1Three novel borosilicate bioactive glasses (BBGs) of general formula of 0.05Na2O0.35x 2 0.20B2O30.40SiO2 (molar ratio, where x = MgO or CaO or SrO) were prepared and used to 3 investigate the effect of crystallisation on their properties including cytotoxicity. The three post-4 melt compositions were determined using X-ray fluorescence spectroscopy and crystallisation 5 events were studied using differential thermal analysis and x-ray diffraction. This information was 6 used to determine heat treatments to prepare glass-ceramics by controlled crystallisation. X-ray 7 diffraction analysis and Fourier transform infrared spectroscopy showed that, after higher heat 8 treatment temperatures (800-900 ºC), borosilicate bioactive glass-ceramics (BBGCs) contained 9 mainly borate and silicate crystalline phases. Specifically, BBG-Mg, BBG-Ca and BBG-Sr glass-10 ceramics detected the presence of magnesium silicate-Mg2(SiO3)2 and magnesium borate-Mg2B2O5; 11 wollastonite-2M-CaSiO3 and calcium borate-Ca(BO2)2; and strontium silicate-SrSiO3 and strontium 12 borate-Sr2B2O5, respectively. In vitro cytotoxicity tests were performed using the mouse fibroblast 13 cell line (L929). Glass and glass ceramic at concentrations lower than 50 mg/ml did not exhibit any 14 level of cytotoxicity when compared with the control. However, quantitative evaluation indicated 15 that greater cell growth occurred in the presence of materials with crystalline phases. Control of 16BBGs crystallisation may therefore be used to influence the biocompatibility of these glass-ceramic 17 systems. 18

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“…Powders containing spherical silica are employed in a broad range of applications (electrical, magnetic and structural), and particularly in the processing of plastics (production of nanocomposites) and in adsorptive processes and catalysis [15,16]. Glass-ceramic materials consisting of silica or alumina, which can be used in biomedical purposes, for orthopaedic surgery and implantation, are extremely desirable [17][18][19][20]. The main aim of this work was to synthesise and characterise spherical alumina-silicate nanoceramics using the RF thermal plasma technique and to investigate the influence of the SiO2 particle size on the microstructural features of the final products.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of spherical amorphous alumo-silicate nanoparticles using RF thermal plasma method

Jankeviciute

Károly

Tarakina

et al. 2013

Journal of Non-Crystalline Solids

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The RF thermal plasma synthesis route was used for the preparation of alumo-silicate spherical particles. Homogeneous solid mixtures of raw materials (Al 2 O 3 , SiO 2 and KOH) were used as precursors. SiO 2 powders with different particle sizes (6 μm and 40 μm) were taken for this synthesis. For the characterization of obtained materials, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD) analysis, infrared spectroscopy (FTIR) and thermogravimetric analysis (TG/DTA) were used. Nanosized amorphous ceramic particles were formed via two-step RF thermal plasma processing. It was demonstrated that the size of the SiO 2 particles plays a significant role in the formation of the alumo-silicate nanoparticles.

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Bioactive SrO–SiO2 glass with well-ordered mesopores: Characterization, physiochemistry and biological properties

Cited by 113 publications

References 35 publications

Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives

Synthesis and characterization of spherical amorphous alumo-silicate nanoparticles using RF thermal plasma method

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