Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment

Yang, Yuxuan; Zhao, Xiaodan; Yu, Jing; Chen, Xingxing; Wang, Ruyue; Zhang, Mengyuan; Zhang, Qiang; Zhang, Yanfeng; Wang, Shuang; Cheng, Yilong

doi:10.1016/j.bioactmat.2021.04.007

Cited by 118 publications

(77 citation statements)

References 65 publications

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“…Besides the biochemical properties, their biophysical structure can significantly mediate cell attachment, shape, viability, the differentiation or pluripotency of stem cells, and even tissue repair and regeneration Cui et al, 2020;Yu et al, 2020;Yu et al, 2021;Zhou et al, 2020;Liu et al, 2021;Yang et al, 2021a;Yang et al, 2021b). Recently, the development of nanofibrous materials has received increasing attention in tissue engineering and regenerative medicine due to their outstanding properties, such as their favorable biological properties, sufficient mechanical strength, highly porous mesh with interconnectivity, extremely high specific surface area, and aspect ratio (Zhou et al, 2015;Zhou et al, 2017;Kenry and Lim, 2017;Xue et al, 2019;Ahmadi et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Fucoidan-Based Electrospun Nanofibers and Their Interaction With Endothelial Cells

Chen

Zhu

Hao

et al. 2021

Front. Bioeng. Biotechnol.

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Sulfated polysaccharide fucoidan (FD) is widely applied in biomedical applications owing to its outstanding bioactivities. In addition to the biochemical features, the architecture of biomaterials plays a critical role in tissue repair and regeneration. Particularly, nanofibers have elicited great interest due to their extracellular matrix-like structure, high specific surface area, and favorable biological properties. Herein, chitosan-modified FD/ultra-high molecular weight polyethylene oxide (UHMWPEO) nanofibers are developed via green electrospinning and electrostatic interaction for studying their interaction with endothelial cells. The appropriate solvent is screened to dissolve FD. The electrospinnability of FD/UHMWPEO aqueous solutions is greatly dependent on the weight ratios of FD/UHMWPEO. The incorporation of UHMWPEO significantly improves the electrospinnability of solution and thermo-stability of nanofibers. Also, it is found that there is good miscibility or no phase separation in FD/UHMWPEO solutions. In vitro biological experiments show that the chitosan-modified FD/UHMWPEO nanofibers greatly facilitate the adhesion of endothelial cells and inhibit the attachment of monocytes. Thus, the designed FD-based nanofibers are promising bio-scaffolds in building tissue-engineered blood vessels.

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Section: Introductionmentioning

confidence: 99%

Preparation of Fucoidan-Based Electrospun Nanofibers and Their Interaction With Endothelial Cells

Chen

Zhu

Hao

et al. 2021

Front. Bioeng. Biotechnol.

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“…The wound healing process proceeds through overlapping phases namely, hemostasis, inflammation, proliferation and remodelling stages [ 1 ]. But this routine healing is delayed in chronic wound conditions, a major example being diabetic wounds [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive peptides laden nano and micro-sized particles enriched ECM inspired dressing for skin regeneration in diabetic wounds

Nanditha

Kumar

2022

Materials Today Bio

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“…So, another important function of bioadhesives is immobilization. They can immobilize themselves as functional wound dressings to promote wound healing without other fixation methods (Yang et al, 2021). They can also be employed as vehicles to deliver functional items like drugs or cells to realize local delivery (Patel et al, 2014;Hu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Applications of Bioadhesives: A Mini Review

Duan

Bian

2021

Front. Bioeng. Biotechnol.

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Bioadhesives have demonstrated their superiority in clinical applications as tissue adhesives, hemostats, and tissue sealants. Because of the intrinsic stickiness, the applications have been expanded to various areas, such as functional wound dressing, factor delivery vehicles, and even medical device fixation. While many literature works discussed the mechanism of bioadhesives, few of them specifically summarized the applications of bioadhesives. To fill in the blanks, this review covers recent research articles and focuses precisely on the applications of bioadhesives which can be generally classified as follows: 1) wound closure, 2) sealing leakage, and 3) immobilization, including those already in the clinic and those showing great potential in the clinic. It is expected that this article will provide a whole picture on bioadhesives’ applications and lead to innovations in the application of bioadhesives in new fields.

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Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment

Cited by 118 publications

References 65 publications

Preparation of Fucoidan-Based Electrospun Nanofibers and Their Interaction With Endothelial Cells

Preparation of Fucoidan-Based Electrospun Nanofibers and Their Interaction With Endothelial Cells

Bioactive peptides laden nano and micro-sized particles enriched ECM inspired dressing for skin regeneration in diabetic wounds

Applications of Bioadhesives: A Mini Review

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