Bioactive sesquiterpenes isolated from the essential oil of Dalbergia odorifera T. Chen

Tao, Yi; Wang, Yi

doi:10.1016/j.fitote.2009.11.012

Cited by 35 publications

(29 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ENL and SDL. SDL was newly identified from Jiangxiang in our previous study [21]. To the best of our knowledge, the pharmacological activities of ENL and SDL, and their potential protein targets have not been previously reported.…”

Section: Discussionmentioning

confidence: 99%

“…18143, Sigma, Germany). (3S,6S,7R)-3,7,11-trimethyl-3,6-epoxy-1,10-dodecadien-7-ol (SDL) and (3S,6R,7R)-3,7,11-trimethyl-3,6-epoxy-1,10-dodecadien-7-ol (RDL) was extracted from volatile oil of Dalbergia odorifera T. Chen [21] ( Fig. 1A ).…”

Section: Methodsmentioning

confidence: 99%

“…Twelve compounds including astragaloside IV (Ast), calycosin (Cal) and formononetin (For) from Huangqi; danshensu (DSS), protocatechuic aldehyde (PCA) and rosmarinic acid (RSA) from Danshen; ginsenoside Rg1 (Rg1), ginsenoside Rb1 (Rb1) and notoginsenoside R1 (R1) from Sanqi; trans-nerolidol (ENL), (3S,6S,7R)-3,7,11-trimethyl-3,6-epoxy-1,10-dodecadien-7-ol (SDL) and (3S,6R,7R)-3,7,11-trimethyl-3,6-epoxy-1,10-dodecadien-7-ol (RDL) from Jiangxiang are main components of QSYQ, and they were absorbed into blood and distributed into tissues after oral administration [20]. SDL and RDL were identified in Jiangxiang in our previous study [21]. However, the potential targets and the underlying molecular mechanisms of actions of these 12 compounds remain to be systematically elucidated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Network Pharmacology Study of Chinese Medicine QiShenYiQi to Reveal Its Underlying Multi-Compound, Multi-Target, Multi-Pathway Mode of Action

Liu

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

Chinese medicine is a complex system guided by traditional Chinese medicine (TCM) theories, which has proven to be especially effective in treating chronic and complex diseases. However, the underlying modes of action (MOA) are not always systematically investigated. Herein, a systematic study was designed to elucidate the multi-compound, multi-target and multi-pathway MOA of a Chinese medicine, QiShenYiQi (QSYQ), on myocardial infarction. QSYQ is composed of Astragalus membranaceus (Huangqi), Salvia miltiorrhiza (Danshen), Panax notoginseng (Sanqi), and Dalbergia odorifera (Jiangxiang). Male Sprague Dawley rat model of myocardial infarction were administered QSYQ intragastrically for 7 days while the control group was not treated. The differentially expressed genes (DEGs) were identified from myocardial infarction rat model treated with QSYQ, followed by constructing a cardiovascular disease (CVD)-related multilevel compound-target-pathway network connecting main compounds to those DEGs supported by literature evidences and the pathways that are functionally enriched in ArrayTrack. 55 potential targets of QSYQ were identified, of which 14 were confirmed in CVD-related literatures with experimental supporting evidences. Furthermore, three sesquiterpene components of QSYQ, Trans-nerolidol, (3S,6S,7R)-3,7,11-trimethyl-3,6-epoxy-1,10-dodecadien-7-ol and (3S,6R,7R)-3,7,11-trimethyl-3,6-epoxy-1,10-dodecadien-7-ol from Dalbergia odorifera T. Chen, were validated experimentally in this study. Their anti-inflammatory effects and potential targets including extracellular signal-regulated kinase-1/2, peroxisome proliferator-activated receptor-gamma and heme oxygenase-1 were identified. Finally, through a three-level compound-target-pathway network with experimental analysis, our study depicts a complex MOA of QSYQ on myocardial infarction.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Network Pharmacology Study of Chinese Medicine QiShenYiQi to Reveal Its Underlying Multi-Compound, Multi-Target, Multi-Pathway Mode of Action

Liu

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Dissipating blood stasis, regulating the flow of qi, and relieving pain are its main actions in traditional Chinese medicines (Liu et al 2005). Modern pharmacological studies have shown that Jiangxiang possesses various biological activities, such as anti-inflammatory (Lee et al 2009), antiplatelet (Tao and Wang 2009), anticoagulant, antitumor, anti-hyperlipidemic, and vasodilative effects (Zhao et al 2000), as well as stimulating the activity of tyrosinase (Wu and Wang 2003). In addition to the medical functions of Dalbergia species, recent studies (Edmone 2006;Khyasudeen and Abu Bakar 2006;Wang 2006) have focused on enhancing the added value of rosewood furniture.…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Drying Treatments on Preservation of Organic Compounds in Dalbergia bariensis Wood

Yang¹,

Jiang²,

Liu³

et al. 2015

BioResources

View full text Add to dashboard Cite

Rosewood furniture and handicrafts are appreciated by Chinese people on account of their rich aroma and pleasing feel. The unique characteristics of rosewood are attributed to the presence of certain organic compounds in its gum canal and parenchyma cells. However, modern wood drying is different from traditional technology with respect to protecting those valuable organic compounds in wood. In this study, to investigate the valuable organic compounds in Dalbergia bariensis, and the effect of drying treatments on their preservation rates, wood extracts, untreated and treated with conventional drying (CD), vacuum drying (VD), and vacuum freeze drying (VFD), were analyzed by gas chromatographymass spectrometry (GC-MS). The results indicated that there were some compounds with obvious pharmaceutical functions in Dalbergia bariensis, which can be used to improve the furniture function in health care. Also, the preservation of these compounds was affected by drying treatment; VFD drying preserved the maximum amount of organic compounds in wood.

show abstract

“…In addition, this Chinese herb appears to have a direct vasodilatation effect on isolated aortic rings induced by norepinephrine bitartrate (NE) and calcium chloride (CaCl 2 ) [6]. Dalbergia odorifera T. Chen is regarded as a useful treatment for CVD and has been in widespread use in various Chinese herbal preparations, such as Danshen injection, Qi-Shen-Yi-Qi decoction, and Guan-xin-Dan-shen pills [7]. Dalbergia odorifera promotes the circulation of blood and relieves pain such as angina.…”

Section: Introductionmentioning

confidence: 99%

A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease

Xue

Wang

et al. 2012

IJMS

View full text Add to dashboard Cite

Traditional Chinese Medicine (TCM) involves a broad range of empirical testing and refinement and plays an important role in the health maintenance for people all over the world. However, due to the complexity of Chinese herbs, a full understanding of TCM’s action mechanisms is still unavailable despite plenty of successful applications of TCM in the treatment of various diseases, including especially cardiovascular diseases (CVD), one of the leading causes of death. Thus in the present work, by incorporating the chemical predictors, target predictors and network construction approaches, an integrated system of TCM has been constructed to systematically uncover the underlying action mechanisms of TCM. From three representative Chinese herbs, i.e., Ligusticum chuanxiong Hort., Dalbergia odorifera T. Chen and Corydalis yanhusuo WT Wang which have been widely used in CVD treatment, by combinational use of drug absorption, distribution, metabolism and excretion (ADME) screening and network pharmacology techniques, we have generated 64 bioactive ingredients and identified 54 protein targets closely associated with CVD, of which 29 are common targets (52.7%) of the three herbs. The result provides new information on the efficiency of the Chinese herbs for the treatment of CVD and also explains one of the basic theories of TCM, i.e., “multiple herbal drugs can treat one disease”. The predicted potential targets were then mapped to target-disease and target-signal pathway connections, which revealed the relationships of the active ingredients with their potential targets, diseases and signal systems. This means that for the first time, the action mechanism of these three important Chinese herbs for the treatment of CVD is uncovered, by generating and identifying both their active ingredients and novel targets specifically related to CVD, which clarifies some of the common conceptions in TCM, and thus provides clues to modernize such specific herbal medicines.

show abstract

Bioactive sesquiterpenes isolated from the essential oil of Dalbergia odorifera T. Chen

Cited by 35 publications

References 12 publications

A Network Pharmacology Study of Chinese Medicine QiShenYiQi to Reveal Its Underlying Multi-Compound, Multi-Target, Multi-Pathway Mode of Action

A Network Pharmacology Study of Chinese Medicine QiShenYiQi to Reveal Its Underlying Multi-Compound, Multi-Target, Multi-Pathway Mode of Action

Effects of Different Drying Treatments on Preservation of Organic Compounds in Dalbergia bariensis Wood

A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease

Contact Info

Product

Resources

About