Bioactive “self-sensing” optical systems

Domachuk, P.; Perry, Hannah; Amsden, Jason J.; Kaplan, David L.; Omenetto, Fiorenzo G.

doi:10.1063/1.3275719

Cited by 47 publications

(37 citation statements)

References 19 publications

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“…To study the quantitative change in the emission properties of silk-coated NDs, a thin film of silk was coated on top of the NDs positioned on the silicon substrate. Silk processing was carried out using previously published methods [25,26] to yield an aqueous solution of silk fibroin protein, which was then drop-cast on top of NDs/silicon substrate. The solution was left to dry in air until the crystallization of silk formed an optically clear film with thickness ≈850 nm on the top of NDs/silicon substrate.…”

Section: Emission Measurementsmentioning

confidence: 99%

Synthesis and characterization of biocompatible nanodiamond-silk hybrid material

Khalid¹,

Lodin²,

Domachuk³

et al. 2014

Biomed. Opt. Express

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Abstract:A new hybrid material consisting of nanodiamonds (NDs) and silk has been synthesized and investigated. NDs can contain bright fluorescence centers, important for bioprobes to image biological structures at the nanoscale and silk provides a transparent, robust matrix for these nanoparticles in-vivo or in-vitro. The ND-silk hybrid films were determined to be highly transparent in the visible to near infrared wavelength range. The NDs embedded in silk exhibited significant enhancement of emission relative to air, correlating with theoretical predictions. Furthermore, animal toxicity tests confirmed ND-silk films to be non-toxic in an in-vivo mice model. ©201 Optical Society of America

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Section: Emission Measurementsmentioning

confidence: 99%

Synthesis and characterization of biocompatible nanodiamond-silk hybrid material

Khalid¹,

Lodin²,

Domachuk³

et al. 2014

Biomed. Opt. Express

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“…Several bioresorbable optical components have been developed, such as microlens arrays [2], diffraction gratings [3], reflective plates [1], photonic crystals [4], waveguides [5,6] and optical fibers [7,8].…”

Section: Introductionmentioning

confidence: 99%

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

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In the last years bioresorbable materials are gaining increasing interest for building implantable optical components for medical devices. In this work we show the fabrication of bioresorbable optical fibers designed for diffuse optics applications, featuring large core diameter (up to 200 mm) and numerical aperture (0.17) to maximize the collection efficiency of diffused light. We demonstrate the suitability of bioresorbable fibers for timedomain diffuse optical spectroscopy firstly checking the intrinsic performances of the setup by acquiring the instrument response function. We then validate on phantoms the use of bioresorbable fibers by applying the MEDPHOT protocol to assess the performance of the system in measuring optical properties (namely, absorption and scattering coefficients) of homogeneous media. Further, we show an ex-vivo validation on a chicken breast by measuring the absorption and scattering spectra in the 500-1100 nm range using interstitially inserted bioresorbable fibers. This work represents a step toward a new way to look inside the body using optical fibers that can be implanted in patients. These fibers could be useful either for diagnostic (e. g. for monitoring the evolution after surgical interventions) or treatment (e. g. photodynamic therapy) purposes. Picture: Microscopy image of the 100 mm core bioresorbable fiber.

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“…Further, silk has been shown to be suitable for use as a material platform for sophisticated optical and opto-electronic components with features on the micro-and nanoscale (7)(8)(9). The resulting free-standing devices formed from silk are refractive or diffractive and comprise elements ranging from microlens arrays and white-light holograms to diffraction gratings and planar photonic crystals with minimum feature sizes of less than 20 nm (7,9,10). These components provide mechanically stable, high-quality optical elements that are fully degradable, biocompatible, and implantable (11).…”

mentioning

confidence: 99%

Implantable, multifunctional, bioresorbable optics

Tao

Kainerstorfer

Siebert

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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113

108

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Advances in personalized medicine are symbiotic with the development of novel technologies for biomedical devices. We present an approach that combines enhanced imaging of malignancies, therapeutics, and feedback about therapeutics in a single implantable, biocompatible, and resorbable device. This confluence of form and function is accomplished by capitalizing on the unique properties of silk proteins as a mechanically robust, biocompatible, optically clear biomaterial matrix that can house, stabilize, and retain the function of therapeutic components. By developing a form of high-quality microstructured optical elements, improved imaging of malignancies and of treatment monitoring can be achieved. The results demonstrate a unique family of devices for in vitro and in vivo use that provide functional biomaterials with built-in optical signal and contrast enhancement, demonstrated here with simultaneous drug delivery and feedback about drug delivery with no adverse biological effects, all while slowly degrading to regenerate native tissue.

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Bioactive “self-sensing” optical systems

Cited by 47 publications

References 19 publications

Synthesis and characterization of biocompatible nanodiamond-silk hybrid material

Synthesis and characterization of biocompatible nanodiamond-silk hybrid material

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Implantable, multifunctional, bioresorbable optics

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