Bioactive Secondary Metabolites from Fungi of the Genus Cytospora Ehrenb. (Ascomycota)

Abstract

Cytospora is a genus of fungi belonging to the Cytosporaceae family (Sordariomycetes, Ascomycota) considered as a prolific source of specialized metabolites due to their ability to produce diverse secondary metabolites with a broad range of biological activities. Since the first chemical investigation of this genus in the 1980s, further studies have led to the isolation and structural elucidation of several bioactive compounds including cytosporones, nonanolides, macrocyclic dilactones, and terpenoids. This review summarizes, for the first time, the chemical diversity of bioactive secondary metabolites from the genus Cytospora and highlights its potential as an alternative source of secondary metabolites for pharmacological studies. Moreover, this review will serve as a basis for future investigations of compounds of this genus.

Secondary metabolites of mangrove-derived endophytic fungus, Pseudopestalotiopsis species investigated for antimicrobial and antioxidant activities

“…Until recently, when it was reported that microorganisms associated with plants can also provide materials and products with high therapeutic potentials (Subbulakshmi et al, 2012), plants have been a source of bioactive compounds for use as medicines against many types of illnesses (Gouda et al, 2016). Fungi are significantly enhancing structurally new secondary metabolites with promising bioactivities, which is expanding their repertory of biosynthetic and medicinal chemistry (Kianfé, et al, 2023). Marine fungi frequently develop in environments with unusual conditions, which prompts the activation of metabolic pathways and the synthesis of distinctive unidentified molecules that support the fungi's ability to adapt to their environment and survive in marine ecosystems (de Souza Sebastianes et al, 2013;Knowles et al, 2022;Fox & Howlett, 2008).…”