Bioactive Properties of Syzygium cumini (L.) Skeels Pulp and Seed Phenolic Extracts

Santos, Catarina Angeli; Almeida, Felipe Alves de; Quecán, Beatriz Ximena Valencia; Pereira, Patrícia Aparecida Pimenta; Gandra, Kelly Moreira Bezerra; Cunha, Luciana Rodrigues da; Pinto, Uelinton Manoel

doi:10.3389/fmicb.2020.00990

Cited by 36 publications

(48 citation statements)

References 39 publications

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“…Finally, Santos et al studied the antibiofilm and anti-QS activities of the phenolic extracts obtained from the seeds and pulp of Syzygium cumini (L.) Skeels (Myrtaceae) (jambolan), obtaining promising results. Based on these, molecular docking calculations were performed, indicating that several among the compounds of pulp and seed extracts of jambolan, particularly dihydroquercetin, could potentially bind CviR protein, thus interfering with the QS system [ 112 ].…”

Section: Flavonoids Involved In Antibiofilm Activitiesmentioning

confidence: 99%

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

et al. 2021

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Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.

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Section: Flavonoids Involved In Antibiofilm Activitiesmentioning

confidence: 99%

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

et al. 2021

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“…The effects of natural compounds on biofilm formation have been extensively studied, with the goal of identifying the biofilm formation antagonists at sub-lethal concentrations [20][21][22][23]. In fact, the natural compounds at sub-lethal concentrations can interfere with the key steps in biofilm genesis, namely attachment, maturation, and detachment, discouraging the sessile mode of microorganisms [23].…”

Section: Introductionmentioning

confidence: 99%

Effects of the Quinone Oxidoreductase WrbA on Escherichia coli Biofilm Formation and Oxidative Stress

et al. 2021

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The effects of natural compounds on biofilm formation have been extensively studied, with the goal of identifying biofilm formation antagonists at sub-lethal concentrations. Salicylic and cinnamic acids are some examples of these compounds that interact with the quinone oxidoreductase WrbA, a potential biofilm modulator and an antibiofilm compound biomarker. However, WrbA’s role in biofilm development is still poorly understood. To investigate the key roles of WrbA in biofilm maturation and oxidative stress, Escherichia coli wild-type and ∆wrbA mutant strains were used. Furthermore, we reported the functional validation of WrbA as a molecular target of salicylic and cinnamic acids. The lack of WrbA did not impair planktonic growth, but rather affected the biofilm formation through a mechanism that depends on reactive oxygen species (ROS). The loss of WrbA function resulted in an ROS-sensitive phenotype that showed reductions in biofilm-dwelling cells, biofilm thickness, matrix polysaccharide content, and H2O2 tolerance. Endogenous oxidative events in the mutant strain generated a stressful condition to which the bacterium responded by increasing the catalase activity to compensate for the lack of WrbA. Cinnamic and salicylic acids inhibited the quinone oxidoreductase activity of purified recombinant WrbA. The effects of these antibiofilm molecules on WrbA function was proven for the first time.

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“…In recent years, polymers with antimicrobial properties have generated significant interest because most solid and semi-solid foods can have microbial growth on their surfaces. In this way, the antimicrobial substance, when establishing an intense contact with the food, inhibits the growth of the microorganisms present in it (Dannenberg et al, 2017;Santos et al, 2020). The release of additives from the active packaging enhances consumer safety as these compounds are not directly added to the food but are released in a controlled manner.…”

Section: Introductionmentioning

confidence: 99%

“…The antimicrobial potential of several natural and synthetic entities has been analyzed in line with this concept such as metal ions, organic acids, bacteriocins and fungicides including benzoates and sorbates (Oliveira & Oliveira, 2004). Importantly, phenolic extracts obtained from plants have also been analyzed recently for their antimicrobial activity (Garzón et al, 2020;Quecán et al, 2019;Rais et al, 2019;Santos et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Pitanga and grumixama extracts: antioxidant and antimicrobial activities and incorporation into cellulosic films against Staphylococcus aureus

Carvalho

Martins

Lima

et al. 2020

RSD

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There is great interest in developing alternatives to improve food safety, since food-borne diseases (FBD) are a major public health concern worldwide. Plant extracts have the potential to inhibit microbial growth due to the action of secondary metabolites, such as phenolic compounds. This study evaluated the antioxidant and antimicrobial activities of phenolic compounds extracted from grumixama (Eugenia brasiliensis) and pitanga (Eugenia uniflora) fruits and the antimicrobial potential of extract of grumixama upon incorporation into cellulosic films. Both fruits were rich in total phenolic compounds and their extracts showed antioxidant activity. The crude and phenolic extracts of grumixama showed higher activity than those isolated from pitanga. All extracts inhibited the growth of Staphylococcus aureus. After incorporation into cellulosic films, the crude extract of grumixama remained active, reducing the S. aureus population in 4 log cycles. The cellulosic films incorporated with grumixama extract were stable after seven days of storage under refrigeration at 7º C; but they partially lost antimicrobial activity when exposed to UV radiation. These phenolic compound-containing cellulosic films could be used as a complementary preservation method of foods that are prone to contamination with S. aureus.

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Bioactive Properties of Syzygium cumini (L.) Skeels Pulp and Seed Phenolic Extracts

Cited by 36 publications

References 39 publications

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

Effects of the Quinone Oxidoreductase WrbA on Escherichia coli Biofilm Formation and Oxidative Stress

Pitanga and grumixama extracts: antioxidant and antimicrobial activities and incorporation into cellulosic films against Staphylococcus aureus

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