Bioactive properties of medicinal plants from the Algerian flora: Selecting the species with the highest potential in view of application purposes

Ziani, Borhane E.C.; Calhelha, Ricardo C.; Barreira, João C.M.; Barros, Lillian; Hazzit, Mohamed; Ferreira, Isabel C.F.R.

doi:10.1016/j.indcrop.2015.09.034

Cited by 23 publications

(15 citation statements)

References 39 publications

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“…This extract did not demonstrate cytotoxicity in PLP2 cell lines (GI 50 > 400 µg/ mL). These results are in agreement with the work presented by Ziani et al (2015), which studied the bioactive properties of infusions prepared from A. unedo flowers and leaves (rich in phenolic compounds, such as flavonoids, especially flavonols and phenolic acid esters), describing the absence of cytotoxic effects.…”

Section: Cytotoxic Propertiessupporting

confidence: 93%

Stability of a cyanidin-3-O-glucoside extract obtained from Arbutus unedo L. and incorporation into wafers for colouring purposes

et al. 2019

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An extract from Arbutus unedo fruits, rich in anthocyanins, was studied as a natural colorant with bioactive properties (antioxidant, antimicrobial and cytotoxic). The aqueous stability of the extract was monitored using the anthocyanins' content as response (determined by HPLC-DAD) in function of time, temperature and pH. Aided by mechanistic/phenomenological models, the conditions that favours the stabilization of the extract were provided, highlighting the suitability of the colorant for pastry/bakery products. As a case study, the extract was incorporated into wafers and the changes on the nutritional profile, free sugars, fatty acids and antioxidant properties were monitored during 6 days of storage. The results provide information for: i) potential application of the rich extract in anthocyanins for producing a natural colorant with bioactive properties; and ii) shelf-life predictions. The extract incorporation did not cause changes in the nutritional components of wafers but added colorant and antioxidant properties.

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Section: Cytotoxic Propertiessupporting

confidence: 93%

Stability of a cyanidin-3-O-glucoside extract obtained from Arbutus unedo L. and incorporation into wafers for colouring purposes

et al. 2019

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“…The Algerian Sahara has a rich and prestigious heritage of plantbased medicines (Benarba, 2016) and many species are used in traditional phytotherapy, which contributed for the development of new therapeutic pathways (Benarba, 2016;Ziani et al, 2015). Ammodaucus levels of total phenols and flavonoids in the polar organic extracts (ethanolic, methanolic and acetone extracts) of A. leucotrichus from Bechar-Algeria.…”

Section: Introductionmentioning

confidence: 99%

Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck

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Bachari

et al. 2019

Journal of Functional Foods

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Edible Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck are largely used in the Algerian Sahara. In this context, soluble sugars, fatty acids, organic acids, and tocopherols were characterized. Decoctions and hydroethanolic extracts were studied regarding their phenolic compounds by HPLC-DAD-ESI/MSn, and invitro cytotoxic, anti-inflammatory, and antibacterial activities were evaluated. Results indicate high contents of carbohydrates (glucose and sucrose) and significant levels of protein and mineral were recorded for both plants. Malic acid was the major organic acid alongside with α-tocopherol, while PUFA was predominant in M. oleifera and MUFA in A. leucotrichus. Flavonoid derivatives were the most abundant group, being luteolin-O-(malonylglucoside) the main compound in A. leucotrichus and quercetin-3-O-(6″-malonyl-glucoside) and 3-O-caffeoylquininc acid the major molecules in M. oleifera. Extracts exhibited significant cytotoxicity on Hela and MCF-7 cell lines. The anti-inflammatory activity was also higher in the hydroethanolic extracts, which also revealed the highest antibacterial effects, especially for Gram-positive bacteria. leucotrichus Coss. & Dur. (Apiaceae) is an endemic plant in North Africa and is widely used in traditional medicine, especially in the southern Algerian Sahara and Tassili regions (Louail et al., 2016). Leaves and seeds of this plant are consumed in the form of infusions and/or decoctions for several therapeutic cases, such as liver and digestive system ailments, gastroenteritis, diabetes, as also for blood pressure and chest pain (Halla, Boucherit, Boucherit-otmani, Zohra, & Rahmani, 2018; Louail et al., 2016). The fruits are often used as a spice during culinary preparation, and leaves are used as a flavoring herbal in teas (Halla et al., 2018; Louail et al., 2016). Nevertheless, most phytochemical and biological studies on A. leucotrichus are related to the volatile compounds from the essential oils (Gherraf et al., 2017; Halla et al., 2018), and few scientific studies have been conducted towards the phenolic compounds and their functional properties. According to a recent study conducted by Halla, Heleno, Costa, Fernandes, Calhelha, Boucherit, Rodrigues, Ferreira, and Barreiro (2018) using colorimetric reactions, flavonoids, condensed and hydrolysable tannins, coumarins, alkaloids, and terpenoids were found in the Algerian A. leucotrichus aqueous extract obtained by decoction and in the hydromethanolic extract. El Haci, Mazari, Gherib, and Atik Bekkara (2018) reported moderate

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“…The sulforhodamine B assay was performed as previously described. 19 Results were expressed as GI 50 values (sample concentration that inhibited 50% of the net cell growth) in mg mL −1 .…”

Section: Cytotoxicitymentioning

confidence: 99%

“…A cell culture (PLP2) was prepared from a freshly harvested porcine liver obtained from a local slaughter house and cultured as previously described. 19 Before confluence was reached, cells were subcultured and plated in 96-well plates (≈1.0 × 10 4 cells per well), using DMEM with 10% FBS, 100 U mL −1 penicillin and 100 μg mL −1 streptomycin. Results were expressed as GI 50 values, in mg mL −1 .…”

Section: Cytotoxicitymentioning

confidence: 99%

Bioactivity and chemical characterization of Opuntia macrorhiza Engelm. seed oil: potential food and pharmaceutical applications

et al. 2017

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In the food industry, there is a continuous search for ingredients that might provide advantageous properties to food products, either considering their nutritional value or bioactivity, as well as flavouring and technological aspects. Crude oils are good examples of this type of ingredient, especially if obtained from nonconventional sources. Accordingly, the Opuntia macrorhiza Engelm. seed oil (OMSO) was chemically characterized and evaluated for different in vitro and in vivo bioactivities. OMSO presented physicochemical characteristics appropriate to be considered as an edible oil, namely low acidity value, stability to oxidation (high peroxide value and low K and K values), and high contents of unsaturated fatty acids (as shown by the iodine value) and saponifiable matter. Furthermore, this natural oil, owing to its rich phytochemical profile, showed relevant antioxidant activity (especially in lipid peroxidation inhibition assays), α-glucosidase inhibitory activity, cytotoxicity against human tumour cell lines, antibacterial (mainly against Gram positive species) and antifungal properties, as well as anti-inflammatory and analgesic activities. Furthermore, OMSO did not show any sign of acute toxicity on animals, highlighting its possible use in different applications, considering that this natural product is not expected to induce the adverse effects typically associated with synthetic bioactive agents (e.g., ampicillin, amphotericin B, or lysine acetylsalicilate).

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Bioactive properties of medicinal plants from the Algerian flora: Selecting the species with the highest potential in view of application purposes

Cited by 23 publications

References 39 publications

Stability of a cyanidin-3-O-glucoside extract obtained from Arbutus unedo L. and incorporation into wafers for colouring purposes

Stability of a cyanidin-3-O-glucoside extract obtained from Arbutus unedo L. and incorporation into wafers for colouring purposes

Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck

Bioactivity and chemical characterization of Opuntia macrorhiza Engelm. seed oil: potential food and pharmaceutical applications

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