Bioactive Potential of Artocarpus heterophyllus Lam.: PRISMA Based Review

Abstract

Introduction: In India, the plant Artocarpus heterophyllus Lam. is commonly known as "Jackfruit" and has been generally used as food and in many traditional medicines. Objective: The present manuscript aimed to collect description information on phytochemistry, ethnomedical uses, pharmacological activities, and patent of A. heterophyllus Lam. that may help in making a bridge between the research gaps as well as the upcoming future findings. Materials and Methods: The literature survey was based on a PRISMA systematic study that gathered information from various sources, including journals, e-books, and digital databases such as Scopus, Web of Science, Pubmed, and Science Direct from 1991 to 2021. Results: Several bioactive constituents are characterized, including flavonoids, chalcones, flavanols, terpenoids, stilbenoids, and xanthones in the fruit. It also contains tannins, quercetin, gallic acid, saponins, artocarpanone and artocarpin. Many pharmacological studies stated the therapeutic potential of Jackfruit, such as antioxidant, antimicrobial, anti-inflammatory, antifungal, anticancer, and antidiabetic properties. Conclusion: The present manuscript summarizes the phytochemistry and pharmacological properties of A.heterophyllus Lam. And it is also providing information in-vitro and in-vivo concerning experimental studies with patent data which, in turn, makes the herbal drug a promising source in the nutrition and therapeutic aspects.

Research progress of procyanidins in repairing cartilage injury after anterior cruciate ligament tear

“…Abundant hydroxyl groups within procyanidins inhibit bacterial adhesion and coaggregation, reducing biofilm formation and inflammation [ 107 ]. Additionally, procyanidins exhibit antibacterial activity by inhibiting extracellular microbial enzymes, depriving microorganisms of essential substrates for growth, or directly affecting microbial metabolism through oxidative phosphorylation inhibition [ 108 ]. They have demonstrated antibacterial effects against Staphylococcus aureus, Escherichia coli, and Candida albicans strains [ 109 ].…”