Bioactive potential and structural chracterization of sulfated polysaccharide from seaweed (Gracilaria corticata)

Seedevi, Palaniappan; Moovendhan, Meivelu; Viramani, Shanmugam; Shanmugam, Annaian

doi:10.1016/j.carbpol.2016.09.011

Cited by 141 publications

(67 citation statements)

References 33 publications

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“…The antioxidant activity measured by all those methods could be attributed mainly to the presence of phenolic compounds in seaweeds extracts (Vo Dinh, Saravana, Woo, & Chun, 2018 (Seedevi, Moovendhan, Viramani, & Shanmugam, 2017), FRAP (Xie, Wang, Shen, Nie, Gong, Li, et al, 2016), lipid peroxide inhibition (Ben Gara, Ben Abdallah Kolsi, Chaaben, Hammami, Kammoun, Paolo Patti, et al, 2017), and superoxide and hydroxyl radical scavenging assays (Abu, Jiang, Ueno, Okimura, Yamaguchi, & Oda, 2013;Deng, Xu, Fu, Chen, & Xu, 2015), among others.…”

Section: Antioxidant Properties Of Seaweeds and Seaweed Extractsmentioning

confidence: 98%

Characterization and in vitro evaluation of seaweed species as potential functional ingredients to ameliorate metabolic syndrome

Rico

Martín-Diana

Milton-Laskíbar

et al. 2018

Journal of Functional Foods

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This study aimed at identifying seaweed species with optimal characteristics to develop multifunctional foods for metabolic syndrome (MetS) management. Mass spectrometry chemical characterization and bioactive profile evaluation of methanolic extracts from seven commonly consumed seaweeds were compared. Monomeric sugars namely mannitol, fucitol, xylitol and their sulphated analogs as well as lipids (phosphatidic acid, octadecenoic acid, and prostaglandin 2) were detected in seaweeds. Himanthalia elongata showed the highest phenolic content (24.04 µmol GAE/g), and antioxidant activity. This species was the only one showing angiotensin converting enzyme-I inhibitory activity (IC 50 =65 µg/mL). U. pinnatifida and H. elongata extracts were notably more effective reducing pro-inflammatory molecules in lipopolysaccharide-induced RAW 264.7 macrophages. Finally, Ulva spp., Palmaria palmata, U. pinnatifida and H. elongata significantly inhibited triglyceride accumulation in mature 3T3-L1 adipocytes (43-52% inhibition). Among seaweeds, H. elongata showed the highest potential to be used as ingredient in the development of new functional foods for MetS management.

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Section: Antioxidant Properties Of Seaweeds and Seaweed Extractsmentioning

confidence: 98%

Characterization and in vitro evaluation of seaweed species as potential functional ingredients to ameliorate metabolic syndrome

Rico

Martín-Diana

Milton-Laskíbar

et al. 2018

Journal of Functional Foods

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“…These polysaccharides usually have about 90% of linear backbone built up of alternating 3-linked β-d-galactopyranose and 4-linked α-d-galactopyranose residues [11]. The hydroxyl groups of galactose residues in side chains may be substituted by ester sulfate and methyl groups [12]. Therefore, the major sulfated polysaccharides in red algae are generally in the form of sulfated galactans [13].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Depolymerized Sulfated Galactans from Marine Red Algae on the Growth and Adhesion of Diarrheagenic Escherichia coli

Liu

et al. 2019

Marine Drugs

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Active polysaccharides as safe and natural polymers against bacterial diarrhea have been reconsidered as an alternative to antibiotics. This work investigated the inhibiting effect of depolymerized sulfated galactans from Eucheuma serra and Gracilaria verrucosa on the growth and adhesion of diarrheagenic enterotoxigenic Escherichia coli (ETEC) K88. Results showed that the sulfated polysaccharides with molecular weight distribution ≤20.0 kDa exhibited antibacterial activity against ETEC K88. A structure–activity study revealed that the anti-ETEC K88 activity of sulfated polysaccharides is strictly determined by their molecular weight distribution, sulfate group content, and monosaccharide composition. In addition, the promoted nucleic acid release and the fluorescence quenching of membrane proteins were observed after the treatment with selected polysaccharides. Scanning electron microscopy further confirmed that the depolymerized sulfated galactans can effectively inhibit ETEC K88 adhesion. In conclusion, depolymerized sulfated galactans exhibited an inhibitory effect on the growth and adhesion of ETEC K88.

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“…In recent years, several reports have revealed that seaweed polysaccharides exhibit strong free-radical scavenging activity and can be used as antioxidants for the prevention of oxidative damage in living organisms [8], and significant evidence has indicated that the biological activities of polysaccharides depend on their structural features, such as the degree of sulfation and distribution pattern of sulfate, type of glycosidic linkages, branch structures, molecular weight, and monosaccharide composition [9,10]. In addition, some β-(1→3), (1→6) glycosidic linkages are supposed to play important roles in enhancing the antitumor and the immunomodulatory effects [11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Extraction, Structural Characterization, and Potential Antioxidant Activity of the Polysaccharides from Four Seaweeds

Chen

et al. 2016

IJMS

106

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Four seaweed polysaccharides were extracted from Sarcodia ceylonensis, Ulva lactuca L., Gracilaria lemaneiformis, and Durvillaea antarctica, respectively, by microwave-assisted extraction. The effect of three significant variables (extraction time, extraction temperature, and the ratio of water to raw material) on the process for extracting polysaccharides was investigated, along with the optimization of the extraction using the response surface method (RSM) with a Box–Behnken design. The polysaccharide structure, monosaccharide composition, degree of sulfation, and molecular weight (MW) distribution were analyzed by infrared (IR) spectrometry, gas chromatography (GC), and high-performance gel permeation chromatography (HPGPC). IR spectrometry showed that Sarcodia ceylonensis polysaccharide (SCP), Ulva lactuca L. polysaccharide (ULLP), and Durvillaea antarctica polysaccharide (DAP) were all sulfated polysaccharides and, except Gracilaria lemaneiformis polysaccharide (GLP), all belong to β-pyranosidic polysaccharides. The average molecular weight (MW) of SCP, ULLP, GLP, and DAP was 466, 404, 591, and 482 kDa, respectively. The quantitative and comparative results with external standards indicated that the main monosaccharide in SCP and ULLP was mannose; and GLP and DAP were mainly composed of galactose and glucose, respectively. Then the in vitro antioxidant activity of all of the polysaccharides was evaluated using different assays—2,2–azino –bis (3-ethylbenzthiazoline-6- sulfonate) (ABTS), hydroxyl radical, nitrite scavenging capacity, and reducing power—and the relationship between their antioxidant activity and chemical characteristics were also examined. ULLP presented the highest ABTS radical scavenging activity; ULLP, SCP and DAP also showed a strong effect on the ABTS radical scavenging activity. SCP and ULLP exhibited excellent hydroxyl radical scavenging activities, about 83.33% ± 2.31% and 80.07% ± 2.17%, respectively, at 4 mg/mL. The reducing power of DAP was relatively more pronounced than that of the three other polysaccharides. However, the nitrite scavenging activities of the four seaweed polysaccharides were weaker than other antioxidant activity (ABTS), hydroxyl radical scavenging capacity, and reducing power. In addition, GLP exhibited lower activities than the other three samples in all of the tests for the antioxidant activity.

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Bioactive potential and structural chracterization of sulfated polysaccharide from seaweed (Gracilaria corticata)

Cited by 141 publications

References 33 publications

Characterization and in vitro evaluation of seaweed species as potential functional ingredients to ameliorate metabolic syndrome

Characterization and in vitro evaluation of seaweed species as potential functional ingredients to ameliorate metabolic syndrome

Inhibitory Effect of Depolymerized Sulfated Galactans from Marine Red Algae on the Growth and Adhesion of Diarrheagenic Escherichia coli

Extraction, Structural Characterization, and Potential Antioxidant Activity of the Polysaccharides from Four Seaweeds

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