Bioactive polyphenols from Ranunculus macrophyllus Desf. Roots: Quantification, identification and antioxidant activity

Phenolic Characterization Using cLC-DAD Analysis and Evaluation of In Vitro and In Vivo Pharmacological Activities of Ruta tuberculata Forssk

“…Overwhelming evidence has demonstrated that many factors, involving the genetic inheritance, extraction method and the solvent system concept, may affect the extraction yield and influence the diversity and nature of chemical contents between Ruta plants [ 12 , 24 , 40 ]. Indeed, the chemical proprieties of different secondary metabolite classes significantly influence their solubility and consequently their extractability yields [ 7 ]. From these results, we can suggest that hydro-alcoholic solvent was mostly the suitable system used to extract the maximum of recovery vegetal secondary metabolites with high and middle polarity, in particular, the diverse phenolic classes which are well known to possess various pharmacological proprieties such as antioxidant, anti-inflammatory, antiulcerogenic and neuro-protective activities.…”

“…In fact, the reducing power capacities that possess R. tuberculata extracts are probably linked to their polyphenols content, which act similarly as redactors via their electron donating ability. Relevantly, it has been documented that the main antioxidant compounds responsible for the reducing power of plant extracts are the small phenols, based on their power to provide more atoms and, consequently, to effectively reduce the ferric and cupper ions [ 7 , 46 ]. Therefore, it could be stated that the antioxidant potential of polyphenols is strongly related to their redox proprieties, where they act as free radical scavengers through hydrogen and electron transfer mechanisms, as metal ions’ binding agents and as modulators of the endogenous antioxidant systems [ 45 ].…”

“…However, the use of synthetic AChEI drugs is undesirably perceived by consumers due to their side effects, such as hypatotoxicity, gastro-intestinal disturbances, vomiting and diarrhea [ 1 ]. Furthermore, non-steroidal anti-inflammatory drugs (NSAIDs) are given as complementary treatment, but may present some drawbacks when used excessively during a long period of time due to the acquisition of drug resistance phenomenon, which underlines the urgent situation to develop more effective natural anti-inflammatory drugs with fewer undesirable effects [ 6 , 7 ]. Recently, there is a growing interest in studying medicinal plants in order to understand their full pharmacological potential along with preventing the development of chronic and degenerative diseases.…”

Determination of Total Phenolic Content From Plant Extracts Used in Cosmetic Purpose

“…pred . (14) Expressed as a % of x pred , %. At the 95% confidence level, the 2-tailed Student t value for 5 degrees of freedom is 2.571.…”

“…Cosmetic companies must use ingredients registered in database created by the European Commission (CosIng) to market their cosmetic products in the European Union [13]. Many countries follow this regulation since their objectives are to export cosmetic products to Europe and to sustain the efficacy of cosmetic ingredients and products [14]. The market value of medicinal plants market is estimated expected to reach about 5 trillion USDby 2050 [15].…”