Bioactive Polylactide Fibrous Materials Prepared by Crazing Mechanism

Abstract

Bioactive suture materials made of biodegradable polymers containing biologically active substances are increasingly demanded in contemporary surgical practice. Herein, the functional fibrous materials are produced by structural modification of polylactide (PLA) fibers according to the crazing mechanism in water–ethanol solutions. The threshold of ethanol concentration, at which the breaking elongation of the polymer substantially increases (up to 600–700%), is found to be 30 wt%. The crazing mechanism is employed to fill the porous structure of PLA fibers by different antiseptic substances (brilliant green, iodine, and fuchsin). PLA loaded by 0.8 wt% of brilliant green exhibits antimicrobial activity on Escherichia coli and Candida guilliermondii. The additive is released stepwise for a prolongated time period (2.5 months). The addition of 1–6 wt% iodine dramatically accelerates the polymer degradation in sodium‐phosphate buffer solution at 37 °C. The obtained filled fibers may possess great interest for producing suture materials with prolonged action of functional components and variable degradation times.

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

“…Polylactic acid (PLA), due to its physio-chemical and biological properties, is the composite matrix of choice. PLA possesses good physical and mechanical properties [11][12][13], bioresorbable properties [14][15][16][17][18], degradability [19][20][21][22][23], cell compatibility [24,25] and exhibits biological activity in its biocomposites [26][27][28][29][30][31][32]. PLA is not toxic [33,34], has hemostatic ability [35][36][37][38][39][40] and, although it does not have inherent antibacterial properties, it presents synergistic biocidal and anti-bacterial adhesion properties [41][42][43].…”

Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT

“…In this work, polylactide (PLA) was chosen as a polymer matrix, and the compound of gold with cysteine [AuCys] n was chosen as a chelate compound. PLA is a polymer of lactic acid, which is extensively used in pharmaceutical and medical applications due to its biocompatibility and biodegradability [21,22].…”

Unique structure and new thermophysical properties of poly(ethylene oxide) in nanocomposites based on nanoporous polypropylene matrices

“…Evident benefits of EC as the route for the preparation of nanomaterials are primarily related to a facile control over dimensions and morphology of pores by varying tensile strain and structure of the initial polymer. [32][33][34][35][36] Therefore, EC offers unique opportunities to gain a deeper insight into the effect of nanoscale confinement on the structural organization of the incorporated polymer. The objective of this work is concerned with the preparation of the PP-PEO nanocomposites via EC of PP films in the PEO-containing solutions and with the study on structural organization and properties of the incorporated polymer (PEO) within the nanoporous structure of the PP matrix.…”

“…This process is accompanied by the development of the unique well‐organized fibrillar‐porous structure with pore dimensions below 100 nm. Evident benefits of EC as the route for the preparation of nanomaterials are primarily related to a facile control over dimensions and morphology of pores by varying tensile strain and structure of the initial polymer 32–36 . Therefore, EC offers unique opportunities to gain a deeper insight into the effect of nanoscale confinement on the structural organization of the incorporated polymer.…”