Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon

Prasad, Chandan; Imrhan, Victorine; Juma, Shanil; Patterson, Mindy; Prasad, Anand; Tiernan, Casey; Vijayagopal, Parakat

doi:10.3390/metabo5040733

Cited by 22 publications

(12 citation statements)

References 190 publications

(238 reference statements)

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“…High fat diets have demonstrated the ability to be a good model of obesity and metabolic syndrome in laboratory animals models [6][7][8]56,58,59]. However, the efficiency in the use of energy also influences the development of obesity in rodents.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that the effects of thyroid status on hepatic pGluAP and the release of endogenous peptides as cyclo His-Pro (cHP) are determinant in insulin sensitivity and body weight control [56,57]. In our results, HFDs significantly increased the soluble pGluAP activity in the liver (Figure 2A: S, 1.0 ± 0.1 pmol (×10 2 )/min/mg protein; VOO, 1.5 ± 0.0 pmol (×10 2 )/min/mg protein; Bch, 1.4 ± 0.0 pmol (×10 2 )/min/mg protein).…”

Section: Hepatic Trh-degrading Pyroglutamate Aminopeptidase Activity mentioning

confidence: 99%

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The Role of High Fat Diets and Liver Peptidase Activity in the Development of Obesity and Insulin Resistance in Wistar Rats

et al. 2020

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High-fat diets (HFD) have been widely associated with an increased risk of metabolic disorders and overweight. However, a high intake of sources that are rich in monounsaturated fatty acids has been suggested as a dietary agent that is able to positively influence energy metabolism and vascular function. The main objective of this study was to analyze the role of dietary fats on hepatic peptidases activities and metabolic disorders. Three diets: standard (S), HFD supplemented with virgin olive oil (VOO), and HFD supplemented with butter plus cholesterol (Bch), were administered over six months to male Wistar rats. Plasma and liver samples were collected for clinical biochemistry and aminopeptidase activities (AP) analysis. The expression of inducible nitric oxide synthase (iNOS) was also determined by Western blot in liver samples. The diet supplement with VOO did not induce obesity, in contrast to the Bch group. Though the VOO diet increased the time that was needed to return to the basal levels of plasma glucose, the fasting insulin/glucose ratio and HOMA2-%B index (a homeostasis model index of insulin secretion and valuation of β-cell usefulness (% β-cell secretion)) were improved. An increase of hepatic membrane-bound dipeptidyl-peptidase 4 (DPP4) activity was found only in VOO rats, even if no differences in fasting plasma glucagon-like peptide 1 (GLP-1) were obtained. Both HFDs induced changes in hepatic pyroglutamyl-AP in the soluble fraction, but only the Bch diet increased the soluble tyrosyl-AP. Angiotensinase activities that are implicated in the metabolism of angiotensin II (AngII) to AngIV increased in the VOO diet, which was in agreement with the higher activity of insulin-regulated-AP (IRAP) in this group. Otherwise, the diet that was enriched with butter increased soluble gamma-glutamyl transferase (GGT) and Leucyl-AP, iNOS expression in the liver, and plasma NO. In summary, VOO increased the hepatic activity of AP that were related to glucose metabolism (DPP4, angiotensinases, and IRAP). However, the Bch diet increased activities that are implicated in the control of food intake (Tyrosine-AP), the index of hepatic damage (Leucine-AP and GGT), and the expression of hepatic iNOS and plasma NO. Taken together, these results support that the source of fat in the diet affects several peptidases activities in the liver, which could be related to alterations in feeding behavior and glucose metabolism.Nutrients 2020, 12, 636 2 of 17 the past few decades, and it typically it is a part of a cluster of metabolic syndrome conditions that increase the chance of developing several related disorders, such as type 2 diabetes, dyslipidemia, abnormal cholesterol levels, hypertension, stroke, heart disease, and cancer [2,3]. Several studies have documented a positive relationship between a high-fat diet (HFD) intake and obesity [4]. The efficacy of the current strategies of treatment for diseases that are caused by obesity is still not entirely satisfactory, and new approaches must be considered. Several studies ha...

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Section: Discussionmentioning

confidence: 99%

Section: Hepatic Trh-degrading Pyroglutamate Aminopeptidase Activity mentioning

confidence: 99%

The Role of High Fat Diets and Liver Peptidase Activity in the Development of Obesity and Insulin Resistance in Wistar Rats

et al. 2020

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“…Human health is determined by various interacting factors, among which lifestyle, environment, and diet play an important synergistic role in the prevention of several diseases, including cancers. Human intervention trials have provided evidence for protective effects of various polyphenol‐rich foods against chronic disease, including cardiovascular disease, neurodegeneration, and cancer . While there are considerable data suggesting the benefits of polyphenol rich‐diet, conclusions regarding their preventive potential remain unresolved due to several limitations in existing studies.…”

Section: Introductionmentioning

confidence: 99%

Organic honey supplementation reverses pesticide‐induced genotoxicity by modulating DNA damage response

Alleva

Manzella

Gaetani

et al. 2016

Molecular Nutrition Food Res

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“…Examples of functional foods include foods that contain specific minerals, vitamins, fatty acids or dietary fibers, foods with added biologically active substances, such as phytochemicals or other antioxidants and probiotics that contain live beneficial bacterial cultures. 12,13 The sweetness of xylose is about 70% of cane sugars. D-Xylose is accepted by the US Food and Drug Administration as a safe food ingredient (GRAS).…”

Section: Discussionmentioning

confidence: 99%

Impact of Xylose on Glucose-Dehydrogenase-Based Blood Glucose Meters for Patient Self-Testing

Pfützner¹,

Demircik²,

Sachsenheimer³

et al. 2016

J Diabetes Sci Technol

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The pentose xylose is enriched in edible algae, and is increasingly used as a slowly metabolized carbohydrate in functional food. It is known to interfere with glucose-dehydrogenase-based (GDH) blood glucose measurement systems for patients self-testing. The aim of our study was to investigate the extent of xylose interference in commercially available blood glucose meters. A heparinized whole blood sample was manipulated to contain 3 different glucose concentrations (50-80 mg/dL, 130-160 mg/dL, and 250-300 mg/dL) and 4 different xylose concentrations (0 mg/dL, 25 mg/dL, 50 mg/dL, and 100 mg/dL). Each sample was measured 3 times with 2 different strip lots per test meter (AccuChek Aviva, AccuChek Connect, Contour Next, FreeStyle Freedom Lite, FreeStyle Insulinx, MyStar Extra, OneTouch Verio IQ, and Wellion Calla, reference: YSI GlucoStat analyzer). For analysis, we calculated the xylose capture rate, that is, the xylose amount wrongly displayed as glucose. No xylose interference was seen with 4 meters: AccuChek Aviva (mean capture rate 0%), AccuChek Connect (–2%), MyStar Extra (10%), and Wellion Calla (8%). In contrast, substantial interference was observed with Contour Next (100%), FreeStyle Freedom Lite (104%), FreeStyle Insulinx (120%), and OneTouch Verio IQ (162%). We observed xylose interference in several GDH-based meters. This may become important with increased use of xylose in dietary and functional food products, in particular in products designed for weight loss. Our findings may affect the meter selection for patients who are consuming such food products as part of their lifestyle treatment regimen.

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Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon

Cited by 22 publications

References 190 publications

The Role of High Fat Diets and Liver Peptidase Activity in the Development of Obesity and Insulin Resistance in Wistar Rats

The Role of High Fat Diets and Liver Peptidase Activity in the Development of Obesity and Insulin Resistance in Wistar Rats

Organic honey supplementation reverses pesticide‐induced genotoxicity by modulating DNA damage response

Impact of Xylose on Glucose-Dehydrogenase-Based Blood Glucose Meters for Patient Self-Testing

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