Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation

Burcher, Jack T.; DeLiberto, Lindsay K.; Allen, Andrea M.; Kilpatrick, Kaitlyn L.; Bishayee, Anupam

doi:10.1002/med.21969

Cited by 6 publications

(1 citation statement)

References 236 publications

(471 reference statements)

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“…Some epidemiological studies [ 30 , 31 ] have even suggested that monoterpenes might have potential applications in the prevention and treatment of cancer types, such as breast, skin, lung, colon, and prostate carcinomas. Recent research reported on the anticarcinogenic and anti-mutagenic potential of tannins [ 32 , 33 ], showcasing their ability to combat a wide range of bacteria, yeasts, molds, and viruses [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Statistical Mapping of Red Grape Varieties Cultivated in Romanian Organic and Conventional Vineyards

Nicolescu,

Bumbac,

Radulescu

et al. 2023

Plants

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Red grapes are rich in phytochemicals such as phenolics and flavonoids, which are strongly correlated with their antioxidant activity. Thus, grapes as-harvested and grape extracts, especially those obtained from their seeds and pulp, have been reported to have health benefits, and accordingly, grapes and their derivatives are considered potential functional food ingredients. The total phenolic content, total flavonoid content, and the antioxidant activity of skin, pulp, and seeds of four grape varieties grown both in conventional and organic vineyards were examined in this study. Phytochemical characteristics of one native Romanian variety, Feteasca Neagra, were compared with data measured for three red grape varieties more commonly cultivated worldwide (Merlot, Pinot Noir, and Muscat Hamburg). It was found that the seeds of the Pinot Noir variety grown in an organic system contained the highest total phenolics of 169.53 ± 7.32 mg gallic acid equivalents/g and the highest total flavonoid content of 388.25 ± 10.72 mg quercetin equivalents/g, values corresponding to high antioxidant activity (312.84 ± 12.81 mg ascorbic acid equivalents/g). The total flavonoid content in the hydroalcoholic extracts obtained from seeds of Pinot Noir (organic vineyard) was around 24.5-fold higher than that of the skin of Pinot Noir (conventional vineyard). Experiments showed that seeds of all four tested grape varieties are good sources of total flavonoids, not only of total phenolics. When referring to the organic vineyard, the skin and pulp grapes showed good results for the total phenolic content. The antioxidant activities of the hydroalcoholic extracts were well-correlated with the total phenolic content and total flavonoid content. Lower values of these parameters were found for extracts obtained from skin and pulp than for those obtained from seeds of the same grape variety regardless of the culture management system (organic/conventional). Data mining techniques such as regression analysis, principal component analysis, and clustering analysis were applied to establish the potential correlation between the phytochemical content and the antioxidant activities of the red grapes on the one hand, and grape variety, anatomical parts, and vineyard type (organic/conventional) on the other hand.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Statistical Mapping of Red Grape Varieties Cultivated in Romanian Organic and Conventional Vineyards

Nicolescu,

Bumbac,

Radulescu

et al. 2023

Plants

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Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies

Bishayee,

Penn,

Bhandari

et al. 2024

Phytotherapy Research

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Oral cancer is a disease with high mortality and rising incidence worldwide. Although fragmentary literature on the anti‐oral cancer effects of plant products has been published, a comprehensive analysis is lacking. In this work, a critical and comprehensive evaluation of oral cancer preventative or therapeutic effects of dietary plants was conducted. An exhaustive analysis of available data supports that numerous dietary plants exert anticancer effects, including suppression of cell proliferation, viability, autophagy, angiogenesis, invasion, and metastasis while promoting cell cycle arrest and apoptosis. Plant extracts and products target several cellular mechanisms, such as the reversal of epithelial‐to‐mesenchymal transition and the promotion of oxidative stress and mitochondrial membrane dysfunction by modulation of various signaling pathways. These agents were also found to regulate cellular growth signaling pathways by action on extracellular signal‐regulated kinase and mitogen‐activated protein kinase, inflammation via modulation of cyclooxygenase (COX)‐1, COX‐2, and nuclear factor‐κB p65, and metastasis through influence of cadherins and matrix metalloproteinases. In vivo studies support these findings and demonstrate a decrease in tumor burden, incidence, and hyperplastic and dysplastic changes. Clinical studies also showed decreased oral cancer risk. However, high‐quality studies should be conducted to establish the clinical efficacy of these plants. Overall, our study supports the use of dietary plants, especially garlic, green tea, longan, peppermint, purple carrot, saffron, tomato, and turmeric, for oral cancer prevention and intervention. However, further research is required before clinical application of this strategy.

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Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation

Cited by 6 publications

References 236 publications

Phytochemical Statistical Mapping of Red Grape Varieties Cultivated in Romanian Organic and Conventional Vineyards

Phytochemical Statistical Mapping of Red Grape Varieties Cultivated in Romanian Organic and Conventional Vineyards

Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies

Comment on “Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments”

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