Bioactive peptides in plant-derived foodstuffs

Maestri, Elena; Marmiroli, Marta; Marmiroli, Nelson

doi:10.1016/j.jprot.2016.03.048

Cited by 154 publications

(83 citation statements)

References 164 publications

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“…Due to the complexity of mechanisms and to variability of in vivo responses (Leroux-Roels et al, 1994; Table 2), focusing on specific changes in either innate or adaptive immunity leads to incorrect conclusions about peptide activities, which can be corrected by measuring changes in both adaptive and innate immunities (Maestri et al, 2016). Anti-inflammatory activity can be determined in vivo by the paw edema test, measuring swelling (as change in volume) after injection of inflammatory substance (Tavares et al, 2013), or in vitro by monitoring macrophage activity using chemiluminescence assays (changes in respiratory burst; Tompa et al, 2011), cytokine secretion (usually by ELISA; Tompa et al, 2011), or by monitoring monocyte adhesion to vascular endothelium (Aihara et al, 2009).…”

Section: Immunomodulatory Activitymentioning

confidence: 99%

“…Bioactive peptides derived from cyclic peptides, such as different classes of defensins (Jenssen, Hamill, & Hancock, 2006), were also included in the analysis (Table S2). Peptide hormones are usually a better source of bioactive peptides in plants (Maestri, Marmiroli, & Marmiroli, 2016;Sánchez & Vázquez, 2017;Schaller, 2001) compared to animals, where hormones, such as insulin, glucagon, and so on, are ubiquitinated and their constituent AAs are used for synthesis of other endogenous peptides and proteins (Ferro, Hyslop, & Camargo, 2004;Glickman & Ciechanover, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Meta‐Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability

Maestri

Pavlićević

Montorsi

et al. 2018

Comp Rev Food Sci Food Safe

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Amino acid (AA) sequences of 807 bioactive peptides from foods of animal origin were examined in order to correlate peptide structure with activity (antihypertensive, antioxidative, immunomodulatory, antimicrobial, hypolipidemic, antithrombotic, and opioid) and stability in vivo. Food sources, such as milk, meat, eggs, and marine products, show different frequencies of bioactive peptides exhibiting specific effects. There is a correlation of peptide structure and effect, depending on type and position of AA. Opioid peptides contain a high percentage of aromatic AA residues, while antimicrobial peptides show an excess of positively charged AAs. AA residue position is significant, with those in the first and penultimate positions having the biggest effects on peptide activity. Peptides that have activity in vivo contain a high percentage (67%) of proline residues, but the positions of proline in the sequence depend on the length of the peptide. We also discuss the influence of processing on activity of these peptides, as well as methods for predicting release from the source protein and activity of peptides.

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Section: Immunomodulatory Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Meta‐Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability

Maestri

Pavlićević

Montorsi

et al. 2018

Comp Rev Food Sci Food Safe

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“…Particularly, oligopeptide is the main digestive product of protein and an important form for absorption (Gilbert et al, 2008). The bioactive peptides derived from natural food proteins have attracted much attention in recently years and are considered to perform physiological activities in the major body systems (Maestri et al, 2016). An array of biological activities of peptides derived from various food sources, including antioxidative (Bernardini et al, 2011), antihypertensive (Contreras et al, 2011), antidiabetic (Shen et al, 2012) and immunomodulatory activities (Qian et al, 2011) has been reported.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, an abundance of studies have focused on the immune regulation activity of peptides from animal and plant proteins (Bhat et al, 2015; Maestri et al, 2016). Studies have shown that peptides derived from food protein hydrolysates in the body can not only improve animal productivity, but also promote animal immunity.…”

Section: Introductionmentioning

confidence: 99%

Oligopeptide derived from solid-state fermented cottonseed meal significantly affect the immunomodulatory in BALB/c mice treated with cyclophosphamide

Liu

Sun

Nie

et al. 2018

Food Sci Biotechnol

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In this study, the immunomodulatory activity of oligopeptide (CP) derived from solid-state fermented cottonseed meal were investigated in immunosuppressed BALB/c mice models by treatment with cyclophosphamide (CY). Results indicated that oligopeptide increased the thymus and spleen indices of CY-treated mice. The count of plague forming cells (PFC) and the content of half serum hemolysis (HC50) in immunosuppressive mice were restored to the normal level in CP-10 and CP-20 groups while the cytokines interleukin (IL)-2, IL-6, and tumor necrosis factor alpha (TNF-α) were increased significantly in CP-20 group. Similar increasing the immunoglobulin of IgG and IgM content in the serum of CP-10 group were also observed. These findings indicated that oligopeptide derived from solid-state fermented cottonseed meal had a strong immune-enhancing activity as well as a protective effect against immunosuppression induced by cyclophosphamide in mice.

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“…RuBisCo is regarded as a good source of essential amino acids (Udenigwe et al, ). Furthermore, several studies in recent years have highlighted its potential as a source of bioactive peptides (Kobbi et al, ; Maestri, Marmiroli, & Marmiroli, ; Rizzello et al, ; Udenigwe & Aluko, ; Yang, Kawamura, & Yoshikawa, ; Yang, Marczak, Yokoo, Usui, & Yoshikawa, ; Yang, Sonoda, Chen, & Yoshikawa, ; Yoshikawa, ; Zhao, Usui, Ohinata, & Yoshikawa, ). These peptides are encrypted within the parent protein and can be released by enzymatic proteolysis or microbial fermentation (Maestri et al, ; Rizzello et al, ; Udenigwe & Aluko, ).…”

Section: Introductionmentioning

confidence: 99%

Plant RuBisCo: An Underutilized Protein for Food Applications

Stefano

Agyei

Njoku³

et al. 2018

J Americ Oil Chem Soc

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Malnutrition is a public health concern and chronic protein malnutrition is prevalent in early childhood in many developing countries. Plant proteins are good candidates for meeting the growing protein needs. RuBisCo (ribulose-1,5-bisphosphate carboxylase/oxygenase) is a photosynthetic enzyme that exists in 4 forms (I, II, III, and IV), with form I being characteristic of higher plants. Form I RuBisCo represents 50% of leaf proteins, and is, therefore, important as a source of protein for nutrition and as a functional ingredient, although the laborious extraction process for plant proteins can limit their use in food products. Column chromatography is the most effective RuBisCo purification step for laboratory research, while ultrafiltration has shown prospects for large-scale applications. RuBisCo has excellent solubility in alkaline pH and at low denaturation temperatures. Thus, RuBisCo can form brittle gels at low concentrations, which can influence the chemosensory properties of products containing the proteins. Foaming of RuBisCo occurs around its isoelectric point, while emulsifying capacity proportionally increases with pH. Heating prior to emulsification increased the strength and stability of emulsion formed with RuBisCo.The protein is also attractive due to its high nutritional values and in vitro digestibility. Furthermore, RuBisCo is a competitive source of bioactive peptides with opioid-like, memory-enhancing, appetite-stimulating, antioxidative, and antihypertensive properties, demonstrating the wide range of food applications where RuBisCo can be utilized.

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Bioactive peptides in plant-derived foodstuffs

Cited by 154 publications

References 164 publications

Meta‐Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability

Meta‐Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability

Oligopeptide derived from solid-state fermented cottonseed meal significantly affect the immunomodulatory in BALB/c mice treated with cyclophosphamide

Plant RuBisCo: An Underutilized Protein for Food Applications

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