Bioactive peptides from meat: Current status on production, biological activity, safety, and regulatory framework

Madhu, Madhuja; Kumar, Deepak; Sirohi, Ranjna; Tarafdar, Ayon; Dhewa, Tejpal; Aluko, Rotimi E.; Badgujar, Prarabdh C.; Awasthi, Mukesh Kumar

doi:10.1016/j.chemosphere.2022.135650

Cited by 22 publications

(15 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After absorption, bioactive peptides may be degraded by proteases and peptidases in the blood or enzymatically hydrolyzed in the kidney and liver before reaching the organs throughout the body . However, due to the limited amount of research, the absorption, distribution, metabolism, and excretion of bioactive peptides are still unclear. , …”

Section: Mechanism Of Antisarcopenic Peptides In Alleviating Sarcopeniamentioning

confidence: 99%

Potential of Food Protein-Derived Bioactive Peptides against Sarcopenia: A Comprehensive Review

Zhu

Wang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Sarcopenia is an age-related progressive muscle disorder characterized by accelerated loss of muscle mass, strength, and function, which are important causes of physiological dysfunctions in the elderly. At present, the main alleviating method includes protein supplements to stimulate synthesis of muscle proteins. Food protein-derived peptides containing abundant branched-chain amino acids have a remarkable effect on the improvement of sarcopenia. Understanding the underlying molecular mechanism and clarifying the structure–activity relationship is essential for the mitigation of sarcopenia. This present review recaps the epidemiology, pathogenesis, diagnosis, and treatment of sarcopenia, which facilitates a comprehensive understanding of sarcopenia. Moreover, the latest research progress on food-derived antisarcopenic peptides is reviewed, including their antisarcopenic activity, molecular mechanism as well as structural characteristics. Food-derived bioactive peptides can indeed alleviate/mitigate sarcopenia. These antisarcopenic peptides play a pivotal role mainly by activating the PI3K/Akt/mTOR and MAPK pathways and inhibiting the ubiquitin-proteasome system and AMPK pathway, thus promoting the synthesis of muscle proteins and inhibiting their degradation. Antisarcopenic peptides alleviate sarcopenia via specific peptides, which may be absorbed into the circulation and exhibit their bioactivity in intact forms. The present review provides a theoretical reference for mitigation and prevention of sarcopenia by food protein-derived bioactive peptides.

show abstract

Section: Mechanism Of Antisarcopenic Peptides In Alleviating Sarcopeniamentioning

confidence: 99%

Potential of Food Protein-Derived Bioactive Peptides against Sarcopenia: A Comprehensive Review

Zhu

Wang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Ashaolu (2020) described the action mechanisms of plant‐derived antioxidative peptides to some length, but those of MDPs have not been described clearly and in detail. Popular techniques used to analyse antioxidant activity are in vitro assays that involve hydrogen atom donation to free radicals and chelating metals to prevent the formation of free radicals (Madhu et al ., 2022). Antioxidative MDPs are described in Table S1.…”

Section: The Biological Potencies Of Mdpsmentioning

confidence: 99%

“…Meat proteins are high in quality, having all the essential amino acids (AAs) required by the human body for overall nutritional and physiological benefits. Since meat proteins are highly digestible, bioavailable in high amounts, produce low molecular weight peptides and are safe, they are more often preferred to other protein sources (Madhu et al ., 2022).…”

Section: Introductionmentioning

confidence: 99%

An updated review of the biological activities, production and safety of meat‐derived peptides

Ashaolu

Suttikhana

2023

Int J of Food Sci Tech

View full text Add to dashboard Cite

Summary Meat‐derived peptides (MDPs) through enzymatic hydrolysis possess an excellent potential for functional foods development except that their safety has always been a major concern. In this review, diligent efforts were made to provide the most updated perspectives on MDPs from multifarious sources, their biological activities and safety issues. In addition to these parameters, their production and market challenges were discussed. High costs involved, poor sensorial qualities, instability, and limited toxicologic and clinical data pose significant challenges to developing functional foods based on MDPs. To ensure the safety of these bioactive peptides and their commercial applications, digestibility, absorbability, metabolism, bioavailability and excretory studies should be considered in preclinical and clinical settings. Further studies in this line of research are of great importance.

show abstract

“…In recent years, bioactive peptides have become a hot topic of research in the field of nutrition due to their easy absorption and multiple physiological roles [ 8 , 9 ]. Bioactive peptides have a faster absorption rate and higher absorption efficiency than proteins and can rapidly participate in energy metabolism, provide good nitrogen sources to the body, and participate in the oxidative energy supply by generating α-keto acids through the process of oxidative deamination [ 8 , 10 , 11 ]. It has been observed in the literature that ginseng, sea cucumber, and walnut oligopeptides, as well as tilapia collagen peptides, can decrease blood lactate levels in mice and produce anti-fatigue effects [ 5 , 6 , 7 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Peanut Oligopeptides on Exercise-Induced Fatigue in Mice and Its Underlying Mechanism

Liu

et al. 2023

Nutrients

View full text Add to dashboard Cite

The aim of this study was to clarify the anti-fatigue effect of peanut oligopeptides (POPs) in mice and to investigate its possible underlying mechanism. A total of 150 male ICR mice were randomly assigned into five groups: control, whey protein (0.50 g/kg·bw), and three peanut peptide groups (0.25, 0.50, and 1.00 g/kg·bw). All the mice were treated with intra-gastric administration for 30 days. Following the intervention, a weight-loaded swimming test, blood lactate concentration, glycogen content, the activities of antioxidant factors and energy metabolism enzymes, and the function of mitochondria in the skeletal muscle were examined. The results show that POP intervention significantly prolonged the exhaustive swimming time, decreased blood lactate concentration levels, regulated the process of energy metabolism, and increased the level of antioxidant enzymes, muscle glycogen, and expressions of mtTFA and NRF-1 in the mitochondria of the gastrocnemius muscle. The results suggest that POPs produce an anti-fatigue effect in the animals, and they may exert this effect through the mechanism of improving the animals’ antioxidant capacity to reduce oxidative damage levels and regulating the process of energy metabolism.

show abstract

Bioactive peptides from meat: Current status on production, biological activity, safety, and regulatory framework

Cited by 22 publications

References 90 publications

Potential of Food Protein-Derived Bioactive Peptides against Sarcopenia: A Comprehensive Review

Potential of Food Protein-Derived Bioactive Peptides against Sarcopenia: A Comprehensive Review

An updated review of the biological activities, production and safety of meat‐derived peptides

The Effects of Peanut Oligopeptides on Exercise-Induced Fatigue in Mice and Its Underlying Mechanism

Contact Info

Product

Resources

About