Bioactive Peptides from Marine Ascidians and Future Drug Development–A Review

Arumugam, Velusamy; Venkatesan, Manigandan; Ramachandran, Saravanan; Sundaresan, Umamaheswari

doi:10.1007/s10989-017-9662-9

Cited by 39 publications

(22 citation statements)

References 46 publications

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“…The multiplicity of the ocean environment has led to marine organisms that are diverse and widely distributed. Since the marine environment is completely different to terrestrial environments, many marine organisms produce active substances with specific functions and special structures: many of which have antibacterial, antiviral and antitumor activities [21]. In recent years, in-depth research has been conducted on marine resources, which has given a new outlook for drug development.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation

et al. 2019

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Fucoxanthin (Fx) is a natural extract from marine seaweed that has strong antioxidant activity and a variety of other bioactive effects. This study elucidated the protective mechanism of Fx on alcoholic liver injury. Administration of Fx was associated with lower pathological effects in liver tissue and lower serum marker concentrations for liver damage induced by alcohol. Fx also alleviated oxidative stress, and lowered the level of oxides and inflammation in liver tissue. Results indicate that Fx attenuated alcohol-induced oxidative lesions and inflammatory responses by activating the nuclear factor erythrocyte-2-related factor 2 (Nrf2)-mediated signaling pathway and down-regulating the expression of the toll-like receptor 4 (TLR4)-mediated nuclear factor-kappa B (NF-κB) signaling pathway, respectively. Our findings suggest that Fx can be developed as a potential nutraceutical for preventing alcohol-induced liver injury in the future.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation

et al. 2019

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“…The SYBR green inLightCycler480 Sequence Detector System (Takara, Japan, Roche, Switzerland) was utilized to perform the real-time PCR. The relative mRNA expression was calculated based on the quantification of ΔΔCt [24]. Genes associated with osteogenesis, which include type I collagen (COLI), runt-associated transcription factor 2 (RUNX2), osterix (OSX), and bone morphogenetic protein 2 (BMP2) were identified on days 3, 7 and 14 Normalization to the gene expression of GAPDH was performed.…”

Section: Quantitative Real-time Pcr Assaymentioning

confidence: 99%

The mTOR/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles

2020

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A novel bioactive inorganic material containing silicon, calcium and oxygen, calcium silicate (Ca 2 SiO 4 , C 2 S) with a CaO-SiO 2 ingredient, has been identified as a potential candidate for artificial bone. Autophagy has an essential function in adult tissue homoeostasis and tumorigenesis. However, little is known about whether silicate nanoparticles (C 2 S NPs) promote osteoblastic differentiation by inducing autophagy. Here we investigated the effects of C 2 S NPs on bone marrow mesenchymal stem cell differentiation (BMSCs) in osteoblasts. Furthermore, we identified the osteogenic gene and protein expression in BMSCs treated with C 2 S NPs. We found that autophagy is important for the ability of C 2 S NPs to induce osteoblastic differentiation of BMSCs. Our results showed that treatment with C 2 S NPs upregulated the expression of BMP2, UNX2, and OSX in BMSCs, and significantly promoted the expression of LC3 and Beclin, while P62 (an autophagy substrate) was downregulated. C 2 S NP treatment could also enhance Alizarin red S dye (ARS), although alkaline phosphatase (ALP) activity was not significantly changed. However, all these effects could be partially reversed by 3-MA. We then detected potential signaling pathways involved in this biological effect and found that C 2 S NPs could activate autophagy by suppressing mTOR and facilitating ULK1 expression. Autophagy further activated β-catenin expression and promoted osteogenic differentiation. In conclusion, C 2 S NPs promote bone formation and osteogenic differentiation in BMSCs by activating autophagy. They achieve this effect by activating mTOR/ ULK1, inducing autophagy, and subsequently triggering the WNT/β-catenin pathway to boost the differentiation and biomineralization of osteoblasts.

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“…Naturally occurring compounds, isolated from marine invertebrates, are a valuable and promising resource for the identification of novel drug leads with unprecedented and novel mechanisms of action [1,2,3]. Until now, about 15,000 species of marine sponges—which are the most primitive and simplest multicellular animal—exist worldwide.…”

Section: Introductionmentioning

confidence: 99%

Total Synthesis of Mycalisine B

et al. 2019

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The first total synthesis of the marine nucleoside Mycalisine B—a naturally occurring and structurally distinct 4,5-unsaturated 7-deazapurine nucleoside—has been accomplished in 10 linear steps with 27.5% overall yield from commercially available 1,2,3,5-tetra-O-acetyl-ribose and tetracyanoethylene. Key steps of the approach include: (1) I2 catalyzed acetonide formation from 1,2,3,5-tetra-O-acetylribose and acetone at large scale; (2) Vorbrüggen glycosylation using N4-benzoyl-5-cyano-6-bromo-7H-pyrrolo[2,3–d]pyrimidine as a nucleobase to avoid formation of N-3 isomer; (3) mild and scalable reaction conditions.

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Bioactive Peptides from Marine Ascidians and Future Drug Development–A Review

Cited by 39 publications

References 46 publications

Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation

Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation

The mTOR/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles

Total Synthesis of Mycalisine B

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