Bioactive peptides from food proteins as potential anti-obesity agents: Mechanisms of action and future perspectives

Suryaningtyas, Indyaswan Tegar; Je, Jae‐Young

doi:10.1016/j.tifs.2023.06.015

Cited by 18 publications

(8 citation statements)

References 90 publications

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“…Obesity is likely to lead to type 2 diabetes mellitus (T2DM), hypertension, and inflammation reactions (H. Guo & Ling, 2015). Adipogenesis is regulated by a complex network of transcription factors, including peroxisome proliferator‐activated receptors (PPARs), sterol regulatory element‐binding proteins, and CCAAT enhancer‐binding protein, which play key roles in adipocyte differentiation, lipid metabolism, and insulin sensitivity (Suryaningtyas & Je, 2023). The anti‐obesity and hypolipidemic effects of BS have been explored both in vitro and in vivo.…”

Section: Health Benefitsmentioning

confidence: 99%

“…is regulated by a complex network of transcription factors, including peroxisome proliferator-activated receptors (PPARs), sterol regulatory element-binding proteins, and CCAAT enhancer-binding protein, which play key roles in adipocyte differentiation, lipid metabolism, and insulin sensitivity(Suryaningtyas & Je, 2023). The anti-obesity and hypolipidemic effects of BS have been explored both in vitro and in vivo.SiyuWang et al (2017) summarized that isoflavones of soybeans possess anti-obesity effects through the regulation of PPAR gamma (PPARγ) and C/EBPα expression.…”

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confidence: 99%

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A systematic review of black soybean (Glycine max (L.) Merr.): Nutritional composition, bioactive compounds, health benefits, and processing to application

Li,

Chen,

Hao

et al. 2024

Food Frontiers

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Owing to concerns about animal proteins, resource limitations, and population growth, there is growing interest in exploring soybeans as animal protein alternatives to fulfill consumption requirements. Black soybean (BS) has superior nutritional and health benefits, compared to yellow soybean (YS). However, BS has been explored less often than YS. While previous reviews have individually focused on the nutritional composition, bioactive compounds, or health benefits of BS, they have not delved into the intricate mechanisms underlying these interactions, especially the distinct roles of the individual components. This comprehensive review aims to bridge this gap by providing an overview of the key nutritional composition and bioactive compounds in BS associated with health benefits, as well as the possible mechanisms underlying these changes. Various processing technologies (physical, biological, and thermal) have been applied to BS. Additionally, the bioavailability, biotransformation, and safety concerns of BS were studied, as these factors are crucial for its potential application, such as natto, films, and microcapsules. However, there are some gaps in the application of BS and YS. In the future, it will be worth exploring the effects of BS protein as meat analogs, 3D printing constituents, and amyloid fibrils, as well as BS lipids as oleogels and BS seed coats as bioactive ingredients in pharmaceutical products.

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Section: Health Benefitsmentioning

confidence: 99%

mentioning

confidence: 99%

A systematic review of black soybean (Glycine max (L.) Merr.): Nutritional composition, bioactive compounds, health benefits, and processing to application

Li,

Chen,

Hao

et al. 2024

Food Frontiers

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“…Bioactive peptides (BAPs) are short chains of amino acids derived from food proteins that have been shown to elicit bene cial physiological effects in humans (Nardo et al, 2020;Purohit et al, 2024;Suryaningtyas and Je, 2023). The identi cation of biological functions including the lowering of lipid levels and blood pressure, antithrombotic characteristics, as well as antioxidant and anti-in ammatory properties, offers a theoretical basis for further research on bioactive peptides(Chaves Filho et al, 2020; Kim et al, 2022;Suryaningtyas and Je, 2023).…”

Section: Introductionmentioning

confidence: 99%

Spirulina platensis peptide-loaded nanoliposomes alleviate hepatic lipid accumulation in Male Wistar Rats by influencing redox homeostasis and lipid metabolism via the AMPK signaling pathway

karimzadeh,

Unniappan,

Zahmatkesh

2024

Preprint

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Spirulina platensis low-molecular-weight peptides (SP) have been reported to exhibit antioxidant and hepatoprotective properties. However, the limited bioavailability and solubility of SPs limit their potential applications. In this study, to examine the potential anti-obesity effects and underlying mechanisms of SPs, high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) model rats were treated with SPs and SP-loaded nanoliposomes. Furthermore, hepatic biochemical parameters, inflammatory markers, histopathological changes, and genes involved in AMPK signaling were analyzed. SP-loaded nanoliposomes demonstrated a spherical shape with slower and sustained SP release. SP and SP-loaded nanoliposomes mitigated hepatic damage by lowering serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST)and increasing hepatic antioxidant enzymes, which are manifested in improving histopathological findings. In addition, and notably SP-loaded nanoliposomes downregulated lipogenic fatty acid synthase (FAS) and sterol regulatory element-binding protein-1c (SREBP-1c) in the liver. Meanwhile, an upregulation of phosphorylated AMP-activated protein kinase (P-AMPK), and lipid acid oxidation-related genes carnitine palmitoyltransferase-1 (CPT-1) and peroxisome proliferator-activated receptor alpha (PPAR-α) was found in the rat liver. This data imply that SP and SP-loaded nanoliposomes exhibit protective potential in rats against the HFD-induced NAFLD, which is mediated through the activation of the AMPK signaling pathway.

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“…They facilitate targeting and interactions with biological processes and receptors associated with lipid metabolism, appetite regulation, and adipogenesis. These bioactive peptides precisely modulate pathways related to obesity, effectively regulating energy balance and weight management [ 12 ]. Recent studies suggest that bioactive peptides derived from various marine proteins, including Scapharca subcrenata [ 13 ], tuna skin collagen [ 14 ], Mustelus mustelus [ 15 ], Gadus chalcogrammus [ 16 ], Ruditapes philippinarum [ 17 ], and Meretrix lusoria [ 18 ], demonstrate anti-obesity and anti-diabetic effects based on their peptide sequence, length, and composition [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Peptides from Meretrix lusoria Enzymatic Hydrolysate as a Potential Treatment for Obesity in db/db Mice

Chilakala,

Moon,

Jung

et al. 2024

Nutrients

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Obesity is acknowledged as a significant risk factor for cardiovascular disease, often accompanied by increased inflammation and diabetes. Bioactive peptides derived from marine animal proteins show promise as safe and effective anti-obesity agents by regulating adipocyte differentiation through the AMPK signaling pathway. Therefore, this study aims to investigate the anti-obesity and anti-diabetic effects of bioactive compounds derived from a Meretrix lusoria Protamex enzymatic hydrolysate (MLP) fraction (≤1 kDa) through a 6-week treatment (150 mg/kg or 300 mg/kg, administered once daily) in leptin receptor-deficient db/db mice. The MLP treatment significantly decreased the body weight, serum total cholesterol, triglycerides, and LDL-cholesterol levels while also exhibiting a beneficial effect on hepatic and serum marker parameters in db/db mice. A histological analysis revealed a reduction in hepatic steatosis and epididymal fat following MLP treatment. Furthermore, poor glucose tolerance was improved, and hepatic antioxidant enzyme activities were elevated in MLP-treated mice compared to db/db control mice. Western blot analysis showed an increased expression of the AMPK protein after MLP treatment. In addition, the expression of lipogenic genes decreased in db/db mice. These findings indicate that bioactive peptides, which are known to regulate blood glucose levels, lipid metabolism, and adipogenesis, could be beneficial functional food additives and pharmaceuticals.

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Bioactive peptides from food proteins as potential anti-obesity agents: Mechanisms of action and future perspectives

Cited by 18 publications

References 90 publications

A systematic review of black soybean (Glycine max (L.) Merr.): Nutritional composition, bioactive compounds, health benefits, and processing to application

A systematic review of black soybean (Glycine max (L.) Merr.): Nutritional composition, bioactive compounds, health benefits, and processing to application

Spirulina platensis peptide-loaded nanoliposomes alleviate hepatic lipid accumulation in Male Wistar Rats by influencing redox homeostasis and lipid metabolism via the AMPK signaling pathway

Bioactive Peptides from Meretrix lusoria Enzymatic Hydrolysate as a Potential Treatment for Obesity in db/db Mice

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