Bioactive peptides derived from traditional Chinese medicine and traditional Chinese food: A review

Liu, Ming; Wang, Yunpu; Liu, Yuhuan; Ruan, Roger

doi:10.1016/j.foodres.2016.08.009

Cited by 48 publications

(28 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are four distinct transport pathways for nutrients to cross the intestinal epithelial cells in the human body including passive diffusion, transcytosis, active carrier‐mediated transport and paracellular transport (Artursson et al ., ; Liu et al ., ). Passive diffusion plays an important role in the transportation of liposoluble components through the cell phospholipid bilayer.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, bioactive peptides would face a big challenge during intestinal absorption due to enzymatic digestion. It has been shown that more than 90% of peptides with >4 amino acid residues are easily hydrolysed (Liu et al, 2016). Apart from digestion, peptides would also need to overcome the physiological barriers of the intestinal epithelium.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The antioxidant activity and transcellular pathway of Asp‐Leu‐Glu‐Glu in a Caco‑2 cell monolayer

Xing

Tang

et al. 2018

Int J of Food Sci Tech

View full text Add to dashboard Cite

Summary Asp‐Leu‐Glu‐Glu (DLEE) is one of the antioxidant peptides purified from Chinese dry‐cured Xuanwei ham in our previous study. In the current work, the stability in a simulated digestion system, the transportation pathway and the antioxidant ability of DLEE were further investigated in a Caco‐2 cell monolayer. In the simulated gastrointestinal digestion system, no oligopeptides were generated. In the transport trial, the inhibitors cytochalasin D increased the transport of DLEE across the Caco‐2 cell monolayer, with Papp values of 3.22 × 10−6 cm s−1. A decreased expression occludin was observed with the DLEE incubation in the cell monolayer, and the antioxidant activity showed to be increased gradually in basolateral side. This study indicates that the absorption of DLEE could mainly occur via paracellular transport and provides information about its antioxidant activity after being absorbed across a cell monolayer.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The antioxidant activity and transcellular pathway of Asp‐Leu‐Glu‐Glu in a Caco‑2 cell monolayer

Xing

Tang

et al. 2018

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…Therefore, gut microbiota produces active metabolites and plays an important role in the pharmacological action of orally administered ginseng. (Baumann and Bisping, 1995;Magee et al, 2000;Blachier et al, 2007;Neis et al, 2015;Liu et al, 2016;Mazzoli and Pessione, 2016;Portune et al, 2016;Velenosi et al, 2016;Lin et al, 2017;Ma et al, 2017;Kaur et al, 2019) Main component: Lipids/fatty acids A variety of different herbs Multiple phyla in microbiota bacteria -conjugated essential fatty acids (conjugated linoleic acid) -trimethyl amine (TMA)…”

Section: Close Interaction Between Tcm Herbs and Gut Microbiota In DImentioning

confidence: 99%

Role of gut microbiota in identification of novel TCM-derived active metabolites

Lin

Lai

et al. 2020

Protein Cell

View full text Add to dashboard Cite

Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.

show abstract

“…Moreover, oligopeptides can completely enter systemic circulation through intestinal mucosa cells. Compared with other bioactive substances, bioactive peptides exert great influence in metabolic regulation, even at small dosages [18]. Various kinds of bioactive peptides, which possess similar functions related to their traditional known efficacy, have been identified from TCM; thus, the real efficacy in some TCM, especially protein-rich TCM, may be derived from their bioactive peptides.…”

Section: Open Accessmentioning

confidence: 99%

Pharmacodynamic material basis of traditional Chinese medicine based on biomacromolecules: a review

et al. 2020

View full text Add to dashboard Cite

Biomacromolecules, the first components of bioactive substances in traditional Chinese medicines (TCM) have wide bioactivity-related efficacy but have not yet been fully appreciated compared to small molecule components. The present review brings a novel and systemic point of view to deepen the understanding of the pharmacodynamic material basis of TCM based on biomacromolecules (polysaccharides, proteins and nucleic acids). Biomacromolecules have been, are and will have considerable roles in the efficacy of Chinese medicine, as evidenced by the number of biological activities related to traditional clinical efficacy. The direct and indirect mechanisms of biomacromolecules are further accounted for in a variety of neurotransmitters, hormones, and immune substances to maintain immune function in both sensitive and stable equilibrium. The biological functions of biomacromolecules have been elaborated on in regard to their roles in the process of plant growth and development to the relationship between primary metabolism and secondary metabolism and to the indispensable role of polysaccharides, proteins, and nucleic acids in the quality formation of TCM. Understanding the functional properties and mechanisms of biological macromolecules will help to demystify the drug properties and health benefits of TCM.

show abstract

Bioactive peptides derived from traditional Chinese medicine and traditional Chinese food: A review

Cited by 48 publications

References 87 publications

The antioxidant activity and transcellular pathway of Asp‐Leu‐Glu‐Glu in a Caco‑2 cell monolayer

The antioxidant activity and transcellular pathway of Asp‐Leu‐Glu‐Glu in a Caco‑2 cell monolayer

Role of gut microbiota in identification of novel TCM-derived active metabolites

Pharmacodynamic material basis of traditional Chinese medicine based on biomacromolecules: a review

Contact Info

Product

Resources

About