Bioactive peptide-bearing polylactic acid fibers as a model of the brain tumor-stimulating microenvironment

Huang, Wanying; Otaka, Akira; Fujita, Shin; Yamaoka, Tetsuji

doi:10.1038/s41428-022-00743-8

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…In particular, nanofiber mats prepared by an electrospinning method offer a large surface-to-volume ratio and high porosity. − These mats are applicable to various devices, including air filters, − water filters, − and battery separators − that are used in the environmental field. They have also been applied in the latest medical fields, such as packed-bed adsorption media for bioseparaors, , wound dressings, − drug-loaded membranes, − and cellular scaffolds. − However, fundamental knowledge regarding the aggregation states and thermal molecular motion of polymer chains in nanofiber mats has yet to be fully clarified. A better understanding of these materials is therefore required as a first benchmark for further development of nanofiber mat-based functional devices.…”

Section: Introductionmentioning

confidence: 99%

Aggregation States and Segmental Dynamics of Poly(methyl methacrylate) in Nanofiber Mats

2023

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Nanofiber mats composed of polymers, having a large surface-to-volume ratio and high porosity, have been widely applied in the environmental and biomedical fields but fundamental knowledge on the polymer chains in the mats seems to be limited. We here report the aggregation states and segmental dynamics of poly(methyl methacrylate)s (PMMAs) with different stereoregularities in electrospun nanofiber mats. Attenuated total reflectance Fourier transform infrared (ATR/FTIR) spectroscopy revealed that, in the case of atactic PMMA (at-PMMA), the population of the trans–trans conformation of the main chain part, which allows carbonyl groups of the side group to interact affirmatively with each other, increased in the electrospun nanofiber mat. On the other hand, in the case of isotactic PMMA (it-PMMA), the skeletal conformation was unchanged even in the nanofiber mat. As a result of the aggregation states of PMMA chains, the glass-transition temperature (T g) of the electrospun nanofiber mats increased and remained unchanged from the corresponding bulk value for at- and it-PMMA, respectively. These findings should be useful for designing materials and devices composed of electrospun nanofibers.

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