Bioactive paper provides a low-cost platform for diagnostics

Pelton, Robert

doi:10.1016/j.trac.2009.05.005

Cited by 505 publications

(451 citation statements)

References 84 publications

(59 reference statements)

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“…However, as cellulose is a hydrophilic material with low nonspecific protein adsorption (which is why mammalian cells do not readily adsorb to cellulose surfaces) (Wu et al 2003;Zou et al 2001;Pelton 2009;Brash and Ten Hove 1993), these scaffolds required the addition of matrix ligands, to facilitate cell attachment to their surfaces (Singh et al 2013;Modulevsky et al 2014;Torres-Rendon et al 2015;Feldmann et al 2015). Watanabe et al (1993) demonstrated that, by introducing an ionic charge to cellulose membranes, collagen could be adsorbed to the membrane surface to promote cellular adhesion.…”

Section: Introductionmentioning

confidence: 99%

Surface modified cellulose scaffolds for tissue engineering

et al. 2016

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We report the ability of cellulose to support cells without the use of matrix ligands on the surface of the material, thus creating a two-component system for tissue engineering of cells and materials. Sheets of bacterial cellulose, grown from a culture medium containing Acetobacter organism were chemically modified with glycidyltrimethylammonium chloride or by oxidation with sodium hypochlorite in the presence of sodium bromide and 2,2,6,6-tetramethylpipiridine 1-oxyl radical to introduce a positive, or negative, charge, respectively. This modification process did not degrade the mechanical properties of the bulk material, but grafting of a positively charged moiety to the cellulose surface (cationic cellulose) increased cell attachment by 70% compared to unmodified cellulose, while negatively charged, oxidised cellulose films (anionic cellulose), showed low levels of cell attachment comparable to those seen for unmodified cellulose. Only a minimal level of cationic surface derivitisation (ca 3% degree of substitution) was required for increased cell attachment and no mediating proteins were required. Cell adhesion studies exhibited the same trends as the attachment studies, while the mean cell area and aspect ratio was highest on the cationic surfaces. Overall, we demonstrated the utility of positively charged bacterial cellulose in tissue engineering in the absence of proteins for cell attachment.

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Section: Introductionmentioning

confidence: 99%

Surface modified cellulose scaffolds for tissue engineering

et al. 2016

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“…The relatively low reactivity of existing groups (mainly C─OH groups) on paper will greatly affect the amount of introduced groups with ATPMS treatment processes (Pelton 2009). However, as a physical modification approach, the chitosan modification method can be applied reproducibly with uniform coating on the surface of paper.…”

Section: Fluorescence Characterizationmentioning

confidence: 99%

Surface Modification of Cellulose Paper for Quantum Dot-based Sensing Applications

Guan¹,

Tian²,

Cao³

et al. 2015

BioResources

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Cellulose paper specimens with and without surface modification were compared in order to study their physicochemical compatibility with quantum dots (QDs) for biochemical sensing applications. Silane and chitosan modification methods were applied. The distribution of QDs deposited on untreated paper and papers modified with silane and chitosan were investigated in order to understand the interaction between QDs and fibre. Modified papers were shown to significantly reduce the undesirable redistribution of QDs during paper drying. The retention ability and thermal resistance of QDs to the loss of fluorescence on modified papers were also studied for the purpose of determining the most suitable paper surface modification for developing QD-Paper-based analytical devices (QD-PADs). Furthermore, chitosan-modified paper was used to design QD-PADs to quantify glucose concentration in aqueous samples; the quenching effect of the enzymatic product on the fluorescent emission of QDs was used as the indicator system. The change of fluorescence of QDs was measured by a simple in-house constructed fluorescence imaging system. The detection limit of glucose was 5 mg/dL, which is comparable with other reported paper sensors for detection of glucose.

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“…Paper, thanks to its availability and affordability, is on top of the list of materials suitable to realize sustainable POC devices [4,5]. Although the lignin removal during pulping processes requires the use of chemicals that may pollute the environment, plastic is made by monomers derived from oil or gas, by addition of various additives, reflecting in a higher pollution when compared with paper.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, Songjaroen et al [20] produced a colorimetric PAD to detect glucose and BSA by simply wax dipping chromatographic paper, while Zhang et al [21] used heated patterned iron components, coated by wax, to stamp a wax pattern into chromatographic paper, detecting hydrogen peroxide. Among several chromatographic papers, Whatman #1 is often chosen as substrate in realizing these newgeneration diagnostic devices due to its surface area, cellulose purity, porosity, uniform thickness, and lightness [5]. Nie et al successfully detected glucose, cholesterol, lactate, and alcohol by integrating an electrode screen-printed on Whatman #1 chromatographic paper in a commercial hand-held glucometer device.…”

Section: Introductionmentioning

confidence: 99%

Sustainable monitoring of Zn(II) in biological fluids using office paper

Cinti

Lellis

Moscone

et al. 2017

Sensors and Actuators B: Chemical

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a b s t r a c tHerein, we describe a sustainable and inexpensive approach to monitor Zn(II) in biological fluids by fabricating an office paper-based electrochemical sensor. By following two easy steps, consisting of wax patterning and electrode screen-printing, the office paper provides an effective electroanalytical tool that is easily extensible to a broad range of analytes. This approach would be able to develop affordable userfriendly sensing devices, tackling the lack of resources in regions with poor-settings/facilities. In order to provide more details regarding the screen-printed electrodes fabrication, office paper, Whatman #1 chromatrographic paper, and polyester have been characterized with electrochemical, morphological, and mechanical tests and compared. Using office paper, Zn(II) has been detected linearly up to 2 g/mL with a detection limit equal to 25 ng/mL and a relative standard deviation of 8%. To highlight the feasibility, reliability, and easiness of the proposed electrochemical sensor, Zn(II) has been detected in serum and sweat at physiological level ( g/mL), and the accuracy of the method has been verified by satisfactory recoveries close to 100%.

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Bioactive paper provides a low-cost platform for diagnostics

Cited by 505 publications

References 84 publications

Surface modified cellulose scaffolds for tissue engineering

Surface modified cellulose scaffolds for tissue engineering

Surface Modification of Cellulose Paper for Quantum Dot-based Sensing Applications

Sustainable monitoring of Zn(II) in biological fluids using office paper

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