Bioactive Oxidised Products of Omega-6 and Omega-3, Excess Oxidative Stress, Oxidised Dietary Intake and Antioxidant Nutrient Deficiencies, in the Context of a Modern Diet

Brown, Robert A.

doi:10.1007/978-3-319-40458-5_28

Cited by 1 publication

(4 citation statements)

References 235 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This relationship could potentially be related to oxidative stress. LA readily reacts with reactive oxygen species, yielding other types of reactive oxygen species that are relatively stable and can spread oxidative damage beyond its initial production site (Yin et al 2011, Brown 2016. Their reaction with the unstable double bonds of the unsaturated fatty acids (including LA) in the sperm membrane can initiate a chain reaction of sperm membrane lipid peroxidation and eventually cause sperm dysfunction (Aitken andBaker 2006, Brown 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Excessive amounts of ω-6 PUFAs can lead to oxidative damage and increased inflammatory responses in both birds and humans (Larsson et al 2004, Cherian 2007, Brown 2016. For example, linoleic acid (LA,, one of the most abundant ω-6 PUFAs in seeds and nuts of terrestrial plants (Hixson et al 2015), reacts readily with reactive oxygen species, yielding lipid radicals, which further oxidize other fatty acids resulting in the chain reaction of lipid peroxidation (Yin et al 2011, Brown 2016. When lipid peroxidation is not inhibited by sufficient amounts of antioxidants, it leads to oxidative damage of cell membranes and elevation in oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

“…When lipid peroxidation is not inhibited by sufficient amounts of antioxidants, it leads to oxidative damage of cell membranes and elevation in oxidative stress. In addition, lipid peroxidation produces relatively stable compounds, such as hydroperoxides, 4-hydroxynonenal and malondialdehyde, that can spread oxidative damage throughout the organism (Yin et al 2011, Brown 2016). On the other hand, whilst excessive ω-6 PUFAs can be detrimental, it is also important to ensure adequate intake of ω-3 PUFAs.…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, a high intake of dietary ω-3 PUFAs has been shown to improve chick fitness in tree swallows (Twining et al 2016b). Importantly, ω-3 and ω-6 PUFAs compete for digestive enzymes, which means that a higher intake of ω-3 can decrease the amount of ω-6 that is metabolised into reactive oxygen species (Brown 2016), emphasising the need for a balance between the two.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sperm head abnormalities are associated with excessive omega‐6 fatty acids in two finch species feeding on sunflower seeds

Støstad

Rowe

Johnsen

et al. 2019

Journal of Avian Biology

View full text Add to dashboard Cite

In a rapidly changing world, it is important to understand how urban environments impact wildlife. For example, supplementary feeding of birds, though well‐intended, might have unexpected negative effects on the health of individual animals. Sunflower seeds are commonly provided in garden bird feeders, but they contain high levels of linoleic acid (LA), an omega‐6 polyunsaturated fatty acid (PUFA). Omega‐6 PUFAs are associated with increased oxidative stress, which can damage cell membranes, and in particular sperm cells. We assessed the level of LA in the blood of two seed‐eating finch species, greenfinches Chloris chloris and hawfinches Coccothraustes coccothraustes, caught in and in environments with direct access to sunflower seed feeders (Norway), and compared these with the level of LA in a smaller number of individuals sampled in in a rural area with low incidence of sunflower seed feeders (Czech Republic). Furthermore, we investigated the relationship between the proportion of LA in the blood (as well as the proportion of 10 other fatty acids) and sperm quality (the frequency of sperm head abnormalities and sperm swimming speed). We found that both finch species, but particularly greenfinches caught near feeders, exhibited levels of LA that were considerably higher than those previously reported for other wild birds. We also found that the proportion of LA was positively correlated with the frequency of abnormal sperm heads (sperm missing the acrosome), while there was no significant effect of fatty acid composition on sperm swimming speed. Our results indicate that the sperm quality of finches may be negatively affected by a high intake of sunflower seeds, adding to a growing body of research showing that supplementary feeding may have detrimental side effects for urban animals. This is particularly relevant for the greenfinch, which is currently affected by disease and population declines.

show abstract

Section: Discussionmentioning

confidence: 99%