Abstract:Natural products represent an inexhaustible source of novel therapeutic agents. Their complex and constrained three-dimensional structures endow these molecules with exceptional biological properties, thereby giving them a major role in drug discovery programs. However, the search for new bioactive metabolites is hampered by the chemical complexity of the biological matrices in which they are found. The purification of single constituents from such matrices requires such a significant amount of work that it sh… Show more
“…Using the aforementioned criteria, these strains are congeneric, and can be assigned to three new hypothetical species represented by strain PMC 1075. 18…”
Section: Phylogenetic and 16s Rrna Dissimilarity-based Identificationmentioning
confidence: 99%
“…Even though, no perfect match was generated through DEREPLICATOR algorithm, marine peptide natural products were proposed and therefore support the relevance of this tool for the exploration of peptide diversity. Furthermore, on the basis of the taxonomic annotation, some clusters were restricted to a single genus indicating the chemical uniqueness of the features within the whole map and, potential structural originality ( Figure S1) [18]. Table 1.…”
Section: Ms/ms Analysis and Annotation Of Cyanobacterial Specialized mentioning
confidence: 99%
“…Most of the cyanobacterial strains showed moderate activity against P. atlantica with a mean growth inhibition of 20% to 60%; three Jaaginema strains PM 1078. 18 Figure S1).…”
Section: Evaluation Of the Antimicrobial Activitymentioning
Benthic cyanobacteria strains from Guadeloupe have been investigated for the first time by combining phylogenetic, chemical and biological studies in order to better understand the taxonomic and chemical diversity as well as the biological activities of these cyanobacteria through the effect of their specialized metabolites. Therefore, in addition to the construction of the phylogenetic tree, indicating the presence of 12 potentially new species, an LC-MS/MS data analysis workflow was applied to provide an overview on chemical diversity of 20 cyanobacterial extracts, which was linked to antimicrobial activities evaluation against human pathogenic and ichtyopathogenic environmental strains.
“…Using the aforementioned criteria, these strains are congeneric, and can be assigned to three new hypothetical species represented by strain PMC 1075. 18…”
Section: Phylogenetic and 16s Rrna Dissimilarity-based Identificationmentioning
confidence: 99%
“…Even though, no perfect match was generated through DEREPLICATOR algorithm, marine peptide natural products were proposed and therefore support the relevance of this tool for the exploration of peptide diversity. Furthermore, on the basis of the taxonomic annotation, some clusters were restricted to a single genus indicating the chemical uniqueness of the features within the whole map and, potential structural originality ( Figure S1) [18]. Table 1.…”
Section: Ms/ms Analysis and Annotation Of Cyanobacterial Specialized mentioning
confidence: 99%
“…Most of the cyanobacterial strains showed moderate activity against P. atlantica with a mean growth inhibition of 20% to 60%; three Jaaginema strains PM 1078. 18 Figure S1).…”
Section: Evaluation Of the Antimicrobial Activitymentioning
Benthic cyanobacteria strains from Guadeloupe have been investigated for the first time by combining phylogenetic, chemical and biological studies in order to better understand the taxonomic and chemical diversity as well as the biological activities of these cyanobacteria through the effect of their specialized metabolites. Therefore, in addition to the construction of the phylogenetic tree, indicating the presence of 12 potentially new species, an LC-MS/MS data analysis workflow was applied to provide an overview on chemical diversity of 20 cyanobacterial extracts, which was linked to antimicrobial activities evaluation against human pathogenic and ichtyopathogenic environmental strains.
“…8 In academic laboratories, the screening of collections of a few hundred extracts corresponding to a dened corpus is typical in focused studies. [9][10][11][12][13][14] These small collections are easier to handle. Their size is compatible with concomitant metabolite proling and mining and with the capacities of tools currently available for NP prioritisation studies as discussed below.…”
Section: Design Of Np Libraries For Prioritisation Studiesmentioning
confidence: 99%
“…In this respect, an innovative LC-MS/MS-MN-based approach has been developed for the screening of a focused library of Euphorbiaceae plant species. 10,59,60 For this purpose, various layers of information such as biological results and/or taxonomic data have been used to discriminate specic ion clusters to allow for the in ne targeting the isolation of structurally new bioactive NPs. 10 Results of the biological screening of extracts using a chikungunya virus (CHIKV) cell-based assay and an oncogenic Wnt signalling assay were mapped to the MN, and colour tags were applied depending on the IC 50 or EC 50 values obtained.…”
Section: Hsqc Nmr Metabolite Proling Of 39 Extracts Frommentioning
This review focuses on innovative omics approaches related to the prioritisation of natural extracts, to selection of efficient producing strains and to the targeted isolation of their bioactive constituents.
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