Bioactive Natural Products from the Red Sea

Rateb, Mostafa E.; Abdelmohsen, Usama Ramadan

doi:10.3390/md19060289

Cited by 8 publications

(3 citation statements)

References 11 publications

(12 reference statements)

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“…The more than 2000 km-long stretch of coral reef system of the Red Sea, hosting a rich biodiversity with a high number of endemic species, is among the five most extended reefs in the world. Nonetheless, the biota of the Red Sea, in comparison to that of other tropical areas, has not been as extensively investigated as a source of bioactive marine natural products [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites with Anti-Inflammatory Activity from Laurencia majuscula Collected in the Red Sea

et al. 2023

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The chemical investigation of the organic extract of the red alga Laurencia majuscula collected from Hurghada reef in the Red Sea resulted in the isolation of five C15 acetogenins, including four tricyclic ones of the maneonene type (1–4) and a 5-membered one (5), 15 sesquiterpenes, including seven lauranes (6–12), one cuparane (13), one seco-laurane (14), one snyderane (15), two chamigranes (16, 17), two rearranged chamigranes (18, 19) and one aristolane (20), as well as a tricyclic diterpene (21) and a chlorinated fatty acid derivative (22). Among them, compounds 1–3, 5, 7, 8, 10, 11 and 14 are new natural products. The structures and the relative configurations of the isolated natural products have been established based on extensive analysis of their NMR and MS data, while the absolute configuration of maneonenes F (1) and G (2) was determined on the basis of single-crystal X-ray diffraction analysis. The anti-inflammatory activity of compounds 1, 2, 4–8, 10, 12–16, 18 and 20–22 was evaluated by measuring suppression of nitric oxide (NO) release in TLR4-activated RAW 264.7 macrophages in culture. All compounds, except 6, exhibited significant anti-inflammatory activity. Among them, metabolites 1, 4 and 18 did not exhibit any cytostatic activity at the tested concentrations. The most prominent anti-inflammatory activity, accompanied by absence of cytostatic activity at the same concentration, was exerted by compounds 5 and 18, with IC50 values of 3.69 μM and 3.55 μΜ, respectively.

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Section: Introductionmentioning

confidence: 99%

Secondary Metabolites with Anti-Inflammatory Activity from Laurencia majuscula Collected in the Red Sea

et al. 2023

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“…Currently, a highly selective covalently reversible JAK3 inhibitor is discovered in the JAKs family, namely FM-381 [21]. Natural products and their derivatives provide a great contribution to the high-throughput screening and design of potential lead drug skeletons, which are the most aspect of current pharmacological market, due to their unique chemical structures as well as biological functions [22][23][24]. Researches have reported that natural products were used for the treatment of various ailments since ancient times, and historically, huge number of new drug compounds were generated and extracted from nature [25,26].…”

Section: Introductionmentioning

confidence: 99%

Conjoint research of WGCNA, single-cell transcriptome and structural biology reveals the potential targets of IDD development and treatment and JAK3 involvement

Zhao,

Mu,

Zou

et al. 2023

Aging

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Objectives: This study conducted integrated analysis of bulk RNA sequencing, single-cell RNA sequencing and Weighted Gene Co-expression Network Analysis (WGCNA), to comprehensively decode the most essential genes of intervertebral disc degeneration (IDD); then mainly focused on the JAK3 macromolecule to identify natural compounds to provide more candidate drug options in alleviating IDD. Methods: In the first part, we performed single-cell transcriptome analysis and WGCNA workflow to delineate the most pivotal genes of IDD. Then series of structural biology approaches and high-throughput virtual screening techniques were performed to discover potential compounds targeting JAK-STAT signaling pathway, such as Libdock, ADMET, precise molecular docking algorithm and in-vivo drug stability assessment. Results: Totally 4 hub genes were determined in the development of IDD, namely VEGFA, MMP3, TNFSF11, and TIMP3, respectively. Then, 3 novel natural materials, ZINC000014952116, ZINC000003938642 and ZINC000072131515, were determined as potential compounds, with less toxicities and moderate ADME characteristics. In-vivo drug stability assessment suggested that these drugs could interact with JAK3, and their ligand-JAK3 complexes maintained the homeostasis in-vivo , which acted as regulatory role to JAK3 protein. Among them, ZINC000072131515, also known as Menaquinone, demonstrated significant protective roles to alleviate the progression of IDD in vitro , which proved the nutritional therapy in alleviating IDD. Conclusions: This study reported the essential genes in the development of IDD, and also the roles of Menaquinone to ameliorate IDD through inhibiting JAK3 protein. This study also provided more options and resources on JAK3 targeted screening, which may further expand the drug resources in the pharmaceutical market.

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“…Os produtos naturais e suas atividades biológicas representam uma fonte de diversidade química para a descoberta de novos candidatos a fármacos com potencial terapêutico para uma variedade de doenças. Eles são considerados a classe mais bem-sucedida de potenciais medicamentos, sendo que mais de um milhão de substâncias químicas descobertas têm origem nos produtos naturais (Shinde et al, 2019;Chen, Kirchmair, 2020;Rateb, Abdelmohsen, 2021). Apesar de medicamentos provenientes de metabólitos naturais serem menos potente quando comparados a drogas sintéticas, eles representam cerca de 60% do número de medicamentos disponíveis no mercado e são consideradas as drogas com menor chance de causar efeitos adversos e as que apresentam melhor absorção pelo organismo.…”

Section: Produtos Naturais De Organismos Marinhos Provenientes Da Ant...unclassified

Avaliação in vitro do efeito do extrato bruto da alga marinha Gigartina skottsbergii e do extrato bruto e frações do fungo Acremonium sp. sobre o metabolismo oxidativo de neutrófilos humanos mediado por receptores para IgG e complemento

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Bioactive Natural Products from the Red Sea

Abstract: The marine environment has proven to be a rich source of diverse natural products with relevant activities such as anticancer, anti-inflammatory, antiepileptic, immunomodulatory, antifungal, antiviral, and antiparasitic [...]

Cited by 8 publications

References 11 publications

Secondary Metabolites with Anti-Inflammatory Activity from Laurencia majuscula Collected in the Red Sea

Secondary Metabolites with Anti-Inflammatory Activity from Laurencia majuscula Collected in the Red Sea

Conjoint research of WGCNA, single-cell transcriptome and structural biology reveals the potential targets of IDD development and treatment and JAK3 involvement

Avaliação in vitro do efeito do extrato bruto da alga marinha Gigartina skottsbergii e do extrato bruto e frações do fungo Acremonium sp. sobre o metabolismo oxidativo de neutrófilos humanos mediado por receptores para IgG e complemento

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